REFERENCES
0.
2. Teng X, Hu D, Dai Y, et al. Discovery of a G-quadruplex unwinder that unleashes the translation of G-quadruplex-containing mRNA without inducing DNA damage. Angew Chem Int Ed. 2024;63:e202407353.
3. Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A. 2002;99:11593-8.
4. De Armond R, Wood S, Sun D, Hurley LH, Ebbinghaus SW. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry. 2005;44:16341-50.
5. Sahayasheela VJ, Yu Z, Hidaka T, Pandian GN, Sugiyama H. Mitochondria and G-quadruplex evolution: an intertwined relationship. Trends Genet. 2023;39:15-30.
6. Antonicka H, Sasarman F, Nishimura T, Paupe V, Shoubridge EA. The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. Cell Metab. 2013;17:386-98.
7. Zhang Y, Zhao J, Chen X, et al. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nat Commun. 2024;15:9890.
8. Hong J, Xu K, Lee JH. Biological roles of the RNA m6A modification and its implications in cancer. Exp Mol Med. 2022;54:1822-32.
9. Lu N, Rong G, Han W. Epi-immunotherapy in cancer treatment: mechanisms, clinical progress, and future directions. Cancer Innov. 2025;4:e70023.
10. Chen Y, Zhou Z, Chen Y, Chen D. Reading the m6A-encoded epitranscriptomic information in development and diseases. Cell Biosci. 2024;14:124.
12. Vaughn JP, Creacy SD, Routh ED, et al. The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates. J Biol Chem. 2005;280:38117-20.
13. Dell'Oca MC, Quadri R, Bernini GM, et al. Spotlight on G-quadruplexes: from structure and modulation to physiological and pathological roles. Int J Mol Sci. 2024;25.
14. Antcliff A, McCullough LD, Tsvetkov AS. G-quadruplexes and the DNA/RNA helicase DHX36 in health, disease, and aging. Aging. 2021;13:25578-87.
15. Fu JJ, Li LY, Lu GX. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily. Acta Biochim. Biophys Sin. 2002;34:655-61.
16. Fu JJ, Li LY, Liu SF, Xing XW, Liu G, Lu GX. Expression research for human DDX36 and mouse Ddx36 gene in the adult testis. Acta Genet Sin. 2003;30:201-8.
17. Fu L, Wu Q, Fu J. Exploring the biological roles of DHX36, a DNA/RNA G-quadruplex helicase, highlights functions in male infertility: a comprehensive review. Int J Biol Macromol. 2024;268:131811.
18. Creacy SD, Routh ED, Iwamoto F, Nagamine Y, Akman SA, Vaughn JP. G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. J Biol Chem. 2008;283:34626-34.
19. Tran H, Schilling M, Wirbelauer C, Hess D, Nagamine Y. Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. Mol Cell. 2004;13:101-11.
20. Newman M, Sfaxi R, Saha A, Monchaud D, Teulade-Fichou MP, Vagner S. The G-quadruplex-specific RNA helicase DHX36 regulates p53 Pre-mRNA 3’-end processing following UV-induced DNA damage. J Mol Biol. 2017;429:3121-31.
21. Chen MC, Tippana R, Demeshkina NA, et al. Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature. 2018;558:465-9.
22. Chalupníková K, Lattmann S, Selak N, Iwamoto F, Fujiki Y, Nagamine Y. Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain. J Biol Chem. 2008;283:35186-98.
23. Heddi B, Cheong VV, Martadinata H, Phan AT. Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: solution structure of a peptide-quadruplex complex. Proc Natl Acad Sci U S A. 2015;112:9608-13.
24. Kwok CK, Merrick CJ. G-quadruplexes: prediction, characterization, and biological application. Trends Biotechnol. 2017;35:997-1013.
25. Nakata M, Kosaka N, Kawauchi K, Miyoshi D. Quantitative effects of the loop region on topology, thermodynamics, and cation binding of DNA G-quadruplexes. ACS Omega. 2024;9:35028-36.
26. GELLERT M, LIPSETT MN, DAVIES DR. Helix formation by guanylic acid. Proc Natl Acad Sci U S A. 1962;48:2013-8.
28. Fracchioni G, Vailati S, Grazioli M, Pirota V. Structural unfolding of G-quadruplexes: from small molecules to antisense strategies. Molecules. 2024;29.
29. Shiekh S, Kodikara SG, Balci H. Structure, topology, and stability of multiple G-quadruplexes in long telomeric overhangs. J Mol Biol. 2024;436:168205.
30. Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S. Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res. 2006;34:5402-15.
31. Chambers VS, Marsico G, Boutell JM, Di Antonio M, Smith GP, Balasubramanian S. High-throughput sequencing of DNA G-quadruplex structures in the human genome. Nat Biotechnol. 2015;33:877-81.
32. Hänsel-Hertsch R, Spiegel J, Marsico G, Tannahill D, Balasubramanian S. Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing. Nat Protoc. 2018;13:551-64.
33. Marsico G, Chambers VS, Sahakyan AB, et al. Whole genome experimental maps of DNA G-quadruplexes in multiple species. Nucleic Acids Res. 2019;47:3862-74.
34. Kwok CK, Marsico G, Sahakyan AB, Chambers VS, Balasubramanian S. rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome. Nat Methods. 2016;13:841-4.
35. Guo JU, Bartel DP. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Science. 2016;353:aaf5371.
36. Bugaut A, Balasubramanian S. 5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res. 2012;40:4727-41.
37. Millevoi S, Moine H, Vagner S. G-quadruplexes in RNA biology. Wiley Interdiscip Rev RNA. 2012;3:495-507.
38. Decorsière A, Cayrel A, Vagner S, Millevoi S. Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3’-end processing and function during DNA damage. Genes Dev. 2011;25:220-5.
39. Kumari S, Bugaut A, Huppert JL, Balasubramanian S. An RNA G-quadruplex in the 5’ UTR of the NRAS proto-oncogene modulates translation. Nat Chem Biol. 2007;3:218-21.
40. Shahid R, Bugaut A, Balasubramanian S. The BCL-2 5’ untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression. Biochemistry. 2010;49:8300-6.
41. Balkwill GD, Derecka K, Garner TP, Hodgman C, Flint AP, Searle MS. Repression of translation of human estrogen receptor alpha by G-quadruplex formation. Biochemistry. 2009;48:11487-95.
42. Morris MJ, Basu S. An unusually stable G-quadruplex within the 5’-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells. Biochemistry. 2009;48:5313-9.
43. Puig Lombardi E, Londoño-Vallejo A. A guide to computational methods for G-quadruplex prediction. Nucleic Acids Res. 2020;48:1-15.
44. Kikin O, D’Antonio L, Bagga PS. QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences. Nucleic Acids Res. 2006;34 Suppl:W676-82.
45. Bedrat A, Lacroix L, Mergny JL. Re-evaluation of G-quadruplex propensity with G4Hunter. Nucleic Acids Res. 2016;44:1746-59.
46. Iachettini S, Biroccio A, Zizza P. Therapeutic use of G4-ligands in cancer: state-of-the-art and future perspectives. Pharmaceuticals. 2024;17.
47. Gao X, Ma W, Nie J, et al. A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis. 2015;6:e1610.
48. Chen X, Yuan J, Xue G, et al. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun. 2021;12:5043.
49. Chen X, Xue G, Zhao J, et al. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5’ UTR rG4 unwinding and Anp32e translation. Cell Rep. 2022;39:110927.
50. Huang X, Zhao K, Jiang M, Qiu D, Zhou J, Yang Z. The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms. J Biol Chem. 2022;298:101449.
51. Marshall PR, Davies J, Zhao Q, et al. DNA G-quadruplex is a transcriptional control device that regulates memory. J Neurosci. 2024;44:e0093232024.
52. Schultz RJ, Amaral JZ, Bridges CS, et al. Gartland classification concordance of supracondylar fractures among pediatric emergency medicine physicians, radiologists, and orthopedic surgeons. Pediatr Radiol. 2024;54:1180-6.
53. Fu X, Zhang F, Dong X, et al. Adapting cytoskeleton-mitochondria patterning with myocyte differentiation by promyogenic PRR33. Cell Death Differ. 2025;32:177-93.
54. Guo Q, Luo Q, Song G. Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance. J Cachexia Sarcopenia Muscle. 2024;15:466-76.
56. Zhang K, Zhang T, Zhang Y, et al. DNA/RNA helicase DHX36 is required for late stages of spermatogenesis. J Mol Cell Biol. 2023;14:mjac069.
57. Siebert-Kuss LM, Krenz H, Tekath T, et al. Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns. Life Sci Alliance. 2023;6:e202201633.
58. Johnson ML, Wang R, Sperry AO. Novel localization of aurora a kinase in mouse testis suggests multiple roles in spermatogenesis. Biochem Biophys Res Commun. 2018;503:51-5.
59. Gui Y, Yuan S. Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond. Cell Mol Life Sci. 2021;78:4893-905.
60. Fulka H, Langerova A. Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling? Chromosome Res. 2019;27:129-40.
61. Jiao YX, Bu GW, Wu YW, et al. DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice. Sci Bull. 2025;70:1295-310.
62. Lu QW, Liu SY, Liao XQ, et al. RNA G-quadruplex removal promotes a translational switch after meiosis resumption. Nucleic Acids Res. 2025;53:gkaf067.
63. Wu D, Liu C, Ding L. Follicular metabolic dysfunction, oocyte aneuploidy and ovarian aging: a review. J Ovarian Res. 2025;18:53.
64. Völkers M, Preiss T, Hentze MW. RNA-binding proteins in cardiovascular biology and disease: the beat goes on. Nat Rev Cardiol. 2024;21:361-78.
65. Yang C, Yao J, Yi H, Huang X, Zhao W, Yang Z. To unwind the biological knots: the DNA/RNA G-quadruplex resolvase RHAU (DHX36) in development and disease. Animal Model Exp Med. 2022;5:542-9.
66. Jiang M, Hu H, Zhao K, et al. The G4 resolvase RHAU modulates mRNA translation and stability to sustain postnatal heart function and regeneration. J Biol Chem. 2021;296:100080.
67. Zhang K, Nie Q, Li M, et al. RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. Nucleic Acids Res. 2025;53:gkaf039.
68. Scalzitti S, Mariani D, Setti A, et al. Lnc-SMaRT translational regulation of spire1, a new player in muscle differentiation. J Mol Biol. 2022;434:167384.
69. Marshall PR, Bredy TW. What does the future hold for the study of nucleic acid modifications in the brain? In: Bredy TW, Editor. DNA Modifications in the Brain. Academic Press; 2017. pp. 149-59.
70. Fan Y, Lv X, Chen Z, Peng Y, Zhang M. m6A methylation: critical roles in aging and neurological diseases. Front Mol Neurosci. 2023;16:1102147.
71. Chen J, Zhang YC, Huang C, et al. m6A regulates neurogenesis and neuronal development by modulating histone methyltransferase Ezh2. Genom Proteom Bioinform. 2019;17:154-68.
72. Fleming AM, Nguyen NLB, Burrows CJ. Colocalization of m6A and G-quadruplex-forming sequences in viral RNA (HIV, Zika, Hepatitis B, and SV40) suggests topological control of adenosine N6-methylation. ACS Cent Sci. 2019;5:218-28.
73. Zhen D, Wu Y, Zhang Y, et al. m6A reader: epitranscriptome target prediction and functional characterization of N6-methyladenosine (m6A) readers. Front Cell Dev Biol. 2020;8:741.
74. Li F, Li W. Readers of RNA modification in cancer and their anticancer inhibitors. Biomolecules. 2024;14:881.
75. Fitzsimmons CM, Batista PJ. It’s complicated… m6A-dependent regulation of gene expression in cancer. Biochim Biophys Acta Gene Regul Mech. 2019;1862:382-93.
76. Chen L, Gao Y, Xu S, et al. N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms. Front Immunol. 2023;14:1162607.
77. Mizumoto A, Yokoyama Y, Miyoshi T, Takikawa M, Ishikawa F, Sadaie M. DHX36 maintains genomic integrity by unwinding G-quadruplexes. Genes Cells. 2023;28:694-708.
78. Wei C, Xu D, Cheng J, et al. DHX36 plays an oncogenic role in breast cancer progression and invasiveness. Sci Rep. 2025;16:1156.
79. Wang Q, Chen P, Wang X, et al. piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2. Noncoding RNA Res. 2023;8:174-86.
80. Gumina JM, Richardson AE, Shojiv MH, et al. Differential gene expression following DHX36/G4R1 knockout is associated with G-quadruplex content and cancer. Int J Mol Sci. 2024;25:1753.
81. Meier-Stephenson V, Badmalia MD, Mrozowich T, et al. Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA. J Biol Chem. 2021;296:100589.
82. Salam KA, Furuta A, Noda N, et al. Inhibition of hepatitis C virus NS3 helicase by manoalide. J Nat Prod. 2012;75:650-4.
83. Yoo JS, Takahasi K, Ng CS, et al. DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. PLoS Pathog. 2014;10:e1004012.
84. Ren Y, Chen M, Wu G, et al. High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells. Sci Rep. 2021;11:21227.
85. Zhang Y, Li Y, Li H, et al. DHX36, BAX, and ARPC1B may be critical for the diagnosis and treatment of tuberculosis. Can Respir J. 2020;2020:4348371.
86. Migneault F, Gagnon F, Pascariu M, et al. Post-transcriptional modulation of aENaC mRNA in alveolar epithelial cells: involvement of its 3’ untranslated region. Cell Physiol Biochem. 2019;52:984-1002.
87. Liu G, Du W, Xu H, et al. RNA G-quadruplex regulates microRNA-26a biogenesis and function. J Hepatol. 2020;73:371-82.
88. Lai JC, Ponti S, Pan D, et al. The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood. 2012;119:4291-300.
89. Nie J, Jiang M, Zhang X, et al. Post-transcriptional regulation of Nkx2-5 by RHAU in heart development. Cell Rep. 2015;13:723-32.
90. Nikpay M, Soubeyrand S, Tahmasbi R, McPherson R. Multiomics Screening Identifies Molecular Biomarkers Causally Associated With the Risk of Coronary Artery Disease. Circ Genom Precis Med. 2020;13:e002876.
91. Tseng YJ, Sandwith SN, Green KM, et al. The RNA helicase DHX36-G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat-associated translation. J Biol Chem. 2021;297:100914.
92. Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556-60.
93. He PC, He C. m6A RNA methylation: from mechanisms to therapeutic potential. EMBO J. 2021;40:e105977.
94. Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA. Cell. 2020;181:1582-1595.e18.
96. Matsumura K, Kawasaki Y, Miyamoto M, et al. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration. Oncogene. 2017;36:1191-9.
97. Cui Y, Li Z, Cao J, et al. The G4 Resolvase DHX36 possesses a prognosis significance and exerts tumour suppressing function through multiple causal regulations in non-small cell lung cancer. Front Oncol. 2021;11:655757.
98. Booy EP, Howard R, Marushchak O, et al. The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. Nucleic Acids Res. 2014;42:3346-61.
99. Thandapani P, Song J, Gandin V, et al. Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes. Elife. 2015;4:e06234.
100. Yuen KL, Pandit K, Puri D, Yodkhunnatham N, Bagrodia A. Testicular cancer with small metastatic burden: optimal approach in 2024. Curr Opin Urol. 2024;34:204-9.
101. Islam R, Heyer J, Figura M, et al. T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets. Br J Cancer. 2024;130:1893-903.
102. Tarrant WP, Czerniak BA, Guo CC. Relationship between primary and metastatic testicular germ cell tumors: a clinicopathologic analysis of 100 cases. Hum Pathol. 2013;44:2220-6.
103. Iida K, Naiki T, Kawai N, et al. Metastasectomy as optimal treatment for late relapsing solitary brain metastasis from testicular germ cell tumor: a case report. BMC Res Notes. 2014;7:865.
104. Rascol O, Ferreira J, Nègre-Pages L, et al. A proof-of-concept, randomized, placebo-controlled, multiple cross-overs (n-of-1) study of naftazone in Parkinson’s disease. Fundam Clin Pharmacol. 2012;26:557-64.
105. Calin GA, Croce CM. MicroRNA-cancer connection: the beginning of a new tale. Cancer Res. 2006;66:7390-4.
106. Aimagambetova G, Terzic M, Marat A, et al. Cervical cancer natural history, diagnosis, and treatment: from molecular events to clinical management. In: Rezaei N, Editors. gynecological cancers: an interdisciplinary approach. Springer, Cham; 2024. pp. 77-116.
108. Hossain MS, Karuniawati H, Jairoun AA, et al. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers. 2022;14:1732.
109. Marshall HM, Fong KM. Lung cancer screening - time for an update? Lung Cancer. 2024;196:107956.
110. Sedeta ET, Jobre B, Avezbakiyev B. Breast cancer: global patterns of incidence, mortality, and trends. J Clin Oncol. 2023;41:10528.
111. Arnold M, Morgan E, Rumgay H, et al. Current and future burden of breast cancer: global statistics for 2020 and 2040. Breast. 2022;66:15-23.
112. Zeng Y, Qin T, Flamini V, et al. Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer. Am J Cancer Res. 2020;10:4211-33.
113. Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A. Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci. 2023;11:42.
114. Son E, Panwar A, Mosher CH, Lydiatt D. Cancers of the major salivary gland. J Oncol Pract. 2018;14:99-108.
115. Karatas OF, Capik O, Barlak N, Aydin Karatas E. Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers. Head Neck. 2021;43:288-302.
117. Chen T, Greene GH, Motley J, et al. m6A modification plays an integral role in mRNA stability and translation during pattern-triggered immunity. Proc Natl Acad Sci U S A. 2024;121:e2411100121.
118. Lin D, Shen Y, Liang T. Oncolytic virotherapy: basic principles, recent advances and future directions. Signal Transduct Target Ther. 2023;8:156.
120. Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642-62.
121. Dai W, Tian R, Yu L, et al. Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma. Nat Commun. 2024;15:131.
123. Mundim AEFM, de Castro FOF, Albuquerque MBB, Vilanova-Costa CAST, Pfrimer IAH, Silva AMTC. Major mutations in the NS3 gene region of hepatitis C virus related to the resistance to direct acting antiviral drugs: a systematic review. Virusdisease. 2020;31:220-8.
124. Frick DN. The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target. Curr Issues Mol Biol. 2007;9:1.
125. Kew MC. Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma. Pathol Biol. 2010;58:273-7.
126. Yu X, Gao Y, Zhang X, et al. Hepatitis B: model systems and therapeutic approaches. J Immunol Res. 2024;2024:4722047.
127. You H, Ma L, Wang X, et al. The emerging role of DEAD/H-box helicases in hepatitis B virus infection. Front Cell Infect Microbiol. 2022;12:1062553.
128. Xu XX, Wan H, Nie L, Shao T, Xiang LX, Shao JZ. RIG-I: a multifunctional protein beyond a pattern recognition receptor. Protein Cell. 2018;9:246-53.
129. Onomoto K, Jogi M, Yoo JS, et al. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS ONE. 2012;7:e43031.
130. Zhang Z, Kim T, Bao M, et al. DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity. 2011;34:866-78.
131. Vasiliu A, Martinez L, Gupta RK, et al. Tuberculosis prevention: current strategies and future directions. Clin Microbiol Infect. 2024;30:1123-30.
132. Stefanovic S, DeMarco BA, Underwood A, Williams KR, Bassell GJ, Mihailescu MR. Fragile X mental retardation protein interactions with a G quadruplex structure in the 3’-untranslated region of NR2B mRNA. Mol Biosyst. 2015;11:3222-30.
133. Bicker S, Khudayberdiev S, Weiß K, Zocher K, Baumeister S, Schratt G. The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134. Genes Dev. 2013;27:991-6.
134. Zampa F, Bicker S, Schratt G. Activity-dependent Pre-miR-134 dendritic localization is required for hippocampal neuron dendritogenesis. Front Mol Neurosci. 2018;11:171.
135. Frobel J, Hänsel-Hertsch R. The age-related decline of helicase function-how G-quadruplex structures promote genome instability. FEBS Lett. 2025;599:267-74.
137. Bloodworth MH, Staso PJ, Huang S, et al. Impact of metabolic and weight components on incident asthma using a real-world cohort. Ann Allergy Asthma Immunol. 2024;133:660-666.e5.
138. Fu X, Dong B, Tian Y, et al. MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. J Clin Invest. 2015;125:2497-509.
139. Appleton E, Chiocca EA, Ungerechts G, Melcher A, Vile R. Oncolytic viruses as anticancer agents: clinical progress and remaining challenges. Lancet. 2025;406:1295-312.
140. Patil KM, Chin D, Seah HL, Shi Q, Lim KW, Phan AT. G4-PROTAC: targeted degradation of a G-quadruplex binding protein. Chem Commun. 2021;57:12816-9.
141. Houweling AC, Somi S, Van Den Hoff MJ, Moorman AF, Christoffels VM. Developmental pattern of ANF gene expression reveals a strict localization of cardiac chamber formation in chicken. Anat Rec. 2002;266:93-102.
142. Greulich F, Rudat C, Kispert A. Mechanisms of T-box gene function in the developing heart. Cardiovasc Res. 2011;91:212-22.
143. Del Monte-Nieto G, Ramialison M, Adam AAS, et al. Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018;557:439-45.
144. Chen H, Shi S, Acosta L, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004;131:2219-31.
