fig1
From: What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia?
Figure 1. The cascade of reactions involved in the UPS. (A) The ubiquitination cascade involves the E1, E2, and E3 ubiquitin ligases and produces a polyubiquitinated end-product. (B) The polyubiquitinated protein is then located by the proteasome which degrades and deubiquitinates the protein. Created with BioRender.com.
