fig2

Figure 2. The HKGI genomic laboratory is designed for a unidirectional workflow, with differential air pressure to prevent contamination between the rooms. Pass-through chambers with interlocking doors allow the transfer of reagents or samples between physically separated rooms without compromising isolation and minimising cross-contamination. The movement of biological samples, reagents, and laboratory personnel strictly follows the unidirectional workflow, from the “No DNA” room to “Low DNA copy” rooms, and finally to the “High DNA copy” room. The Reagent Preparation room holds positive pressure, keeping environmental contaminants from entering, while the Library Preparation and Sequencing rooms hold a negative pressure to contain potential contaminants within the rooms and reduce the risk of contaminating corridors and other rooms.