fig6

Figure 6. ECM-A protein interactomics map. Two intensive co-expression groups containing the nine CAMs were present in an interaction network connected by PTPRZ1 and ITGB2. The genes of CADM1, CADM3, NRXN2, CNTN1, and MZPL1 formed a co-expression group, four of which happened to be highly correlated with sPTL. KEGG pathway showed that CADM1, CADM3, NRXN2, and CNTN1 were expressed in different subcellular compartments. ICAM2, SPN, SIGLEC1, and HLA-DPB1 are usually co-expressed in immune cells.