REFERENCES
1. RetNet™ - The Retinal Information Network. Available from: https://sph.uth.edu/retnet/ [Last accessed on 15 Dec 2021].
2. Hanany M, Rivolta C, Sharon D. Worldwide carrier frequency and genetic prevalence of autosomal recessive inherited retinal diseases. Proc Natl Acad Sci U S A 2020;117:2710-6.
3. Gong J, Cheung S, Fasso-Opie A, et al. The impact of inherited retinal diseases in the United States of America (US) and Canada from a cost-of-illness perspective. Clin Ophthalmol 2021;15:2855-66.
4. Edwards TL, Jolly JK, Groppe M, et al. Visual acuity after retinal gene therapy for choroideremia. N Engl J Med 2016;374:1996-8.
5. Bennett J, Wellman J, Marshall KA, et al. Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial. Lancet 2016;388:661-72.
6. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, et al. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature 2016;540:144-9.
7. Pearson RA, Barber AC, Rizzi M, et al. Restoration of vision after transplantation of photoreceptors. Nature 2012;485:99-103.
8. MacLaren RE, Pearson RA, MacNeil A, et al. Retinal repair by transplantation of photoreceptor precursors. Nature 2006;444:203-7.
9. Sanges D, Simonte G, Di Vicino U, et al. Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors. J Clin Invest 2016;126:3104-16.
10. Salman A, McClements ME, MacLaren RE. Insights on the regeneration potential of Müller glia in the mammalian retina. Cells 2021:10.
11. Jorstad NL, Wilken MS, Grimes WN, et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature 2017;548:103-7.
12. Yao K, Qiu S, Wang YV, et al. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018;560:484-8.
13. Thummel R, Kassen SC, Enright JM, Nelson CM, Montgomery JE, Hyde DR. Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Exp Eye Res 2008;87:433-44.
14. Vihtelic TS, Hyde DR. Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina. J Neurobiol 2000;44:289-307.
15. Fausett BV, Goldman D. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J Neurosci 2006;26:6303-13.
16. Sherpa T, Fimbel SM, Mallory DE, et al. Ganglion cell regeneration following whole-retina destruction in zebrafish. Dev Neurobiol 2008;68:166-81.
17. Nelson CM, Gorsuch RA, Bailey TJ, Ackerman KM, Kassen SC, Hyde DR. Stat3 defines three populations of Müller glia and is required for initiating maximal Müller glia proliferation in the regenerating zebrafish retina. J Comp Neurol 2012;520:4294-311.
18. Qin Z, Barthel LK, Raymond PA. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Proc Natl Acad Sci U S A 2009;106:9310-5.
19. Streisinger G, Singer F, Walker C, Knauber D, Dower N. Segregation analyses and gene-centromere distances in zebrafish. Genetics 1986;112:311-9.
20. Streisinger G, Walker C, Dower N, Knauber D, Singer F. Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature 1981;291:293-6.
21. Vaz R, Hofmeister W, Lindstrand A. Zebrafish models of neurodevelopmental disorders: limitations and benefits of current tools and techniques. Int J Mol Sci 2019:20.
22. Hong Y, Luo Y. Zebrafish model in ophthalmology to study disease mechanism and drug discovery. Pharmaceuticals (Basel) 2021:14.
23. Patton EE, Zon LI, Langenau DM. Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov 2021;20:611-28.
24. Stewart KM, Walker SL, Baker AH, Riley PR, Brittan M. Hooked on heart regeneration: the zebrafish guide to recovery. Cardiovasc Res 2021; doi: 10.1093/cvr/cvab214.
25. Houcke J, Marien V, Zandecki C, Seuntjens E, Ayana R, Arckens L. Modeling neuroregeneration and neurorepair in an aging context: the power of a teleost model. Front Cell Dev Biol 2021;9:619197.
26. Wang X, Zhang JB, He KJ, Wang F, Liu CF. Advances of zebrafish in neurodegenerative disease: from models to drug discovery. Front Pharmacol 2021;12:713963.
27. Noel NCL, Nadolski NJ, Hocking JC, MacDonald IM, Allison WT. Progressive photoreceptor dysfunction and age-related macular degeneration-like features in rp1l1 mutant zebrafish. Cells 2020;9:2214.
28. Gross JM, Perkins BD. Zebrafish mutants as models for congenital ocular disorders in humans. Mol Reprod Dev 2008;75:547-55.
29. Brockerhoff SE, Hurley JB, Janssen-Bienhold U, Neuhauss SC, Driever W, Dowling JE. A behavioral screen for isolating zebrafish mutants with visual system defects. Proc Natl Acad Sci U S A 1995;92:10545-9.
30. Neuhauss SC, Biehlmaier O, Seeliger MW, et al. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci 1999;19:8603-15.
31. Gross JM, Perkins BD, Amsterdam A, et al. Identification of zebrafish insertional mutants with defects in visual system development and function. Genetics 2005;170:245-61.
32. Muto A, Orger MB, Wehman AM, et al. Forward genetic analysis of visual behavior in zebrafish. PLoS Genet 2005;1:e66.
33. Li L, Dowling JE. A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. Proc Natl Acad Sci U S A 1997;94:11645-50.
34. Malicki J, Neuhauss SC, Schier AF, et al. Mutations affecting development of the zebrafish retina. Development 1996;123:263-73.
35. Fadool JM, Brockerhoff SE, Hyatt GA, Dowling JE. Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev Genet 1997;20:288-95.
36. Tsujikawa M, Malicki J. Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons. Neuron 2004;42:703-16.
37. Stearns G, Evangelista M, Fadool JM, Brockerhoff SE. A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish. J Neurosci 2007;27:13866-74.
38. Brockerhoff SE, Rieke F, Matthews HR, et al. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci 2003;23:470-80.
39. Wei X, Malicki J. nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nat Genet 2002;31:150-7.
40. Omori Y, Malicki J. oko meduzy and related crumbs genes are determinants of apical cell features in the vertebrate embryo. Curr Biol 2006;16:945-57.
41. Lessieur EM, Fogerty J, Gaivin RJ, Song P, Perkins BD. The ciliopathy gene ahi1 is required for zebrafish cone photoreceptor outer segment morphogenesis and survival. Invest Ophthalmol Vis Sci 2017;58:448-60.
42. Zelinka CP, Sotolongo-Lopez M, Fadool JM. Targeted disruption of the endogenous zebrafish rhodopsin locus as models of rapid rod photoreceptor degeneration. Mol Vis 2018;24:587-602.
43. Nagashima M, Hitchcock PF. Inflammation regulates the multi-step process of retinal regeneration in zebrafish. Cells 2021;10:783.
44. Stella SL Jr, Geathers JS, Weber SR, et al. Neurodegeneration, neuroprotection and regeneration in the zebrafish retina. Cells 2021;10:633.
45. Var SR, Byrd-Jacobs CA. Role of macrophages and microglia in zebrafish regeneration. Int J Mol Sci 2020:21.
47. Ganzen L, Venkatraman P, Pang CP, Leung YF, Zhang M. Utilizing zebrafish visual behaviors in drug screening for retinal degeneration. Int J Mol Sci 2017;18:1185.
48. Shi Y, Su Y, Lipschutz JH, Lobo GP. Zebrafish as models to study ciliopathies of the eye and kidney. Clin Nephrol Res 2017;1:6-9.
50. Fimbel SM, Montgomery JE, Burket CT, Hyde DR. Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. J Neurosci 2007;27:1712-24.
51. Sherpa T, Lankford T, McGinn TE, et al. Retinal regeneration is facilitated by the presence of surviving neurons. Dev Neurobiol 2014;74:851-76.
52. Dixon-Salazar T, Silhavy JL, Marsh SE, et al. Mutations in the AHI1 gene, encoding jouberin, cause Joubert syndrome with cortical polymicrogyria. Am J Hum Genet 2004;75:979-87.
53. Ferland RJ, Eyaid W, Collura RV, et al. Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome. Nat Genet 2004;36:1008-13.
54. Hsiao YC, Tong ZJ, Westfall JE, Ault JG, Page-McCaw PS, Ferland RJ. Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking. Hum Mol Genet 2009;18:3926-41.
55. Westfall JE, Hoyt C, Liu Q, et al. Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1. J Neurosci 2010;30:8759-68.
56. Sohocki MM, Bowne SJ, Sullivan LS, et al. Mutations in a new photoreceptor-pineal gene on 17p cause Leber congenital amaurosis. Nat Genet 2000;24:79-83.
57. der Spuy J, Chapple JP, Clark BJ, Luthert PJ, Sethi CS, Cheetham ME. The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retina. Hum Mol Genet 2002;11:823-31.
58. Hidalgo-de-Quintana J, Evans RJ, Cheetham ME, van der Spuy J. The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex. Invest Ophthalmol Vis Sci 2008;49:2878-87.
59. Ramamurthy V, Roberts M, van den Akker F, Niemi G, Reh TA, Hurley JB. AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins. Proc Natl Acad Sci U S A 2003;100:12630-5.
60. Sacristan-Reviriego A, Le HM, Georgiou M, et al. Clinical and functional analyses of AIPL1 variants reveal mechanisms of pathogenicity linked to different forms of retinal degeneration. Sci Rep 2020;10:17520.
61. Iribarne M, Hyde DR, Masai I. TNFalpha induces Müller glia to transition from non-proliferative gliosis to a regenerative response in mutant zebrafish presenting chronic photoreceptor degeneration. Front Cell Dev Biol 2019;7:296.
63. Katsanis N, Ansley SJ, Badano JL, et al. Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. Science 2001;293:2256-9.
64. Beales PL, Elcioglu N, Woolf AS, Parker D, Flinter FA. New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. J Med Genet 1999;36:437-46.
65. Weihbrecht K, Goar WA, Pak T, et al. Keeping an eye on Bardet-Biedl syndrome: a comprehensive review of the role of Bardet-Biedl syndrome genes in the eye. Med Res Arch 2017;5:10.18103/mra.v5i9.1526.
66. Nachury MV, Loktev AV, Zhang Q, et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007;129:1201-13.
67. Liu P, Lechtreck KF. The Bardet-Biedl syndrome protein complex is an adapter expanding the cargo range of intraflagellar transport trains for ciliary export. Proc Natl Acad Sci U S A 2018;115:E934-E43.
68. Datta P, Allamargot C, Hudson JS, et al. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 2015;112:E4400-9.
69. Song P, Fogerty J, Cianciolo LT, Stupay R, Perkins BD. Cone photoreceptor degeneration and neuroinflammation in the zebrafish Bardet-Biedl syndrome 2 (bbs2) mutant does not lead to retinal regeneration. Front Cell Dev Biol 2020;8:578528.
70. Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B. Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science 2016;352:1341-4.
71. Rachel RA, Yamamoto EA, Dewanjee MK, et al. CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies. Hum Mol Genet 2015;24:3775-91.
72. Gorden NT, Arts HH, Parisi MA, et al. CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290. Am J Hum Genet 2008;83:559-71.
73. Schouteden C, Serwas D, Palfy M, Dammermann A. The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly in C. elegans. J Cell Biol 2015;210:35-44.
74. Chang B, Khanna H, Hawes N, et al. In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet 2006;15:1847-57.
75. Li C, Jensen VL, Park K, et al. MKS5 and CEP290 dependent assembly pathway of the ciliary transition zone. PLoS Biol 2016;14:e1002416.
76. Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, et al. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet 2011;43:776-84.
77. Coppieters F, Lefever S, Leroy BP, De Baere E. CEP290, a gene with many faces: mutation overview and presentation of CEP290base. Hum Mutat 2010;31:1097-108.
78. Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol 2017;18:533-47.
79. den Hollander AI, Koenekoop RK, Yzer S, et al. Mutations in the CEP290 (NPHP6) gene are a frequent cause of Leber congenital amaurosis. Am J Hum Genet 2006;79:556-61.
80. Feldhaus B, Weisschuh N, Nasser F, et al. CEP290 mutation spectrum and delineation of the associated phenotype in a large German cohort: a monocentric study. Am J Ophthalmol 2020;211:142-50.
81. Lessieur EM, Song P, Nivar GC, et al. Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish. PLoS One 2019;14:e0213960.
82. Stawicki TM, Hernandez L, Esterberg R, et al. Cilia-associated genes play differing roles in aminoglycoside-induced hair cell death in zebrafish. G3 (Bethesda) 2016;6:2225-35.
83. Cardenas-Rodriguez M, Austin-Tse C, Bergboer JGM, et al. Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases. J Cell Sci 2021:134.
84. Tuson M, Marfany G, Gonzalez-Duarte R. Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am J Hum Genet 2004;74:128-38.
85. Bornancin F, Mechtcheriakova D, Stora S, et al. Characterization of a ceramide kinase-like protein. Biochim Biophys Acta 2005;1687:31-43.
86. Graf C, Niwa S, Müller M, Kinzel B, Bornancin F. Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun 2008;373:159-63.
87. Aleman TS, Soumittra N, Cideciyan AV, et al. CERKL mutations cause an autosomal recessive cone-rod dystrophy with inner retinopathy. Invest Ophthalmol Vis Sci 2009;50:5944-54.
88. Yu S, Li C, Biswas L, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet 2017;26:2335-45.
89. Arai Y, Maeda A, Hirami Y, et al. Retinitis pigmentosa with EYS mutations is the most prevalent inherited retinal dystrophy in Japanese populations. J Ophthalmol 2015;2015:819760.
90. Abd El-Aziz MM, Barragan I, O'Driscoll CA, et al. EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa. Nat Genet 2008;40:1285-7.
91. Abd El-Aziz MM, O'Driscoll CA, Kaye RS, et al. Identification of novel mutations in the ortholog of Drosophila eyes shut gene (EYS) causing autosomal recessive retinitis pigmentosa. Invest Ophthalmol Vis Sci 2010;51:4266-72.
92. Yu M, Liu Y, Li J, et al. Eyes shut homolog is required for maintaining the ciliary pocket and survival of photoreceptors in zebrafish. Biol Open 2016;5:1662-73.
93. Lu Z, Hu X, Liu F, et al. Ablation of EYS in zebrafish causes mislocalisation of outer segment proteins, F-actin disruption and cone-rod dystrophy. Sci Rep 2017;7:46098.
94. Messchaert M, Dona M, Broekman S, et al. Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish. PLoS One 2018;13:e0200789.
95. Collin RW, Safieh C, Littink KW, et al. Mutations in C2ORF71 cause autosomal-recessive retinitis pigmentosa. Am J Hum Genet 2010;86:783-8.
96. Nishimura DY, Baye LM, Perveen R, et al. Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71. Am J Hum Genet 2010;86:686-95.
97. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, et al. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A 2020;117:9922-31.
98. Corral-Serrano JC, Messchaert M, Dona M, et al. C2orf71a/pcare1 is important for photoreceptor outer segment morphogenesis and visual function in zebrafish. Sci Rep 2018;8:9675.
99. Arshavsky VY, Burns ME. Photoreceptor signaling: supporting vision across a wide range of light intensities. J Biol Chem 2012;287:1620-6.
100. Arshavsky VY, Burns ME. Current understanding of signal amplification in phototransduction. Cell Logist 2014;4:e29390.
101. Piriev NI, Viczian AS, Ye J, Kerner B, Korenberg JR, Farber DB. Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24. Genomics 1995;28:429-35.
102. Huang SH, Pittler SJ, Huang X, Oliveira L, Berson EL, Dryja TP. Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase. Nat Genet 1995;11:468-71.
103. Thiadens AA, den Hollander AI, Roosing S, et al. Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders. Am J Hum Genet 2009;85:240-7.
104. Chang B, Grau T, Dangel S, et al. A homologous genetic basis of the murine cpfl1 mutant and human achromatopsia linked to mutations in the PDE6C gene. Proc Natl Acad Sci U S A 2009;106:19581-6.
105. Nishiwaki Y, Komori A, Sagara H, et al. Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish. Mech Dev 2008;125:932-46.
106. Nishimura T, Kato K, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K. Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol 2004;6:328-34.
107. Crouzier L, Diez C, Richard EM, et al. Loss of Pde6a induces rod outer segment shrinkage and visual alterations in pde6a(Q70X) mutant zebrafish, a relevant model of retinal dystrophy. Front Cell Dev Biol 2021;9:675517.
108. Emran F, Rihel J, Dowling JE. A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. J Vis Exp 2008;(20):923.
109. Kaplan J, Bonneau D, Frezal J, Munnich A, Dufier JL. Clinical and genetic heterogeneity in retinitis pigmentosa. Hum Genet 1990;85:635-42.
110. Pelletier V, Jambou M, Delphin N, et al. Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling. Hum Mutat 2007;28:81-91.
111. Grayson C, Bartolini F, Chapple JP, et al. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum Mol Genet 2002;11:3065-74.
112. Veltel S, Gasper R, Eisenacher E, Wittinghofer A. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol 2008;15:373-80.
113. Evans RJ, Schwarz N, Nagel-Wolfrum K, Wolfrum U, Hardcastle AJ, Cheetham ME. The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum Mol Genet 2010;19:1358-67.
114. Liu F, Chen J, Yu S, et al. Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish. Hum Mol Genet 2015;24:4648-59.
115. Roepman R, Bernoud-Hubac N, Schick DE, et al. The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. Hum Mol Genet 2000;9:2095-105.
116. Boylan JP, Wright AF. Identification of a novel protein interacting with RPGR. Hum Mol Genet 2000;9:2085-93.
117. Dryja TP, Adams SM, Grimsby JL, et al. Null RPGRIP1 alleles in patients with Leber congenital amaurosis. Am J Hum Genet 2001;68:1295-8.
118. Gerber S, Perrault I, Hanein S, et al. Complete exon-intron structure of the RPGR-interacting protein (RPGRIP1) gene allows the identification of mutations underlying Leber congenital amaurosis. Eur J Hum Genet 2001;9:561-71.
119. Hameed A, Abid A, Aziz A, Ismail M, Mehdi SQ, Khaliq S. Evidence of RPGRIP1 gene mutations associated with recessive cone-rod dystrophy. J Med Genet 2003;40:616-9.
120. Hong DH, Yue G, Adamian M, Li T. Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium. J Biol Chem 2001;276:12091-9.
121. Castagnet P, Mavlyutov T, Cai Y, Zhong F, Ferreira P. RPGRIP1s with distinct neuronal localization and biochemical properties associate selectively with RanBP2 in amacrine neurons. Hum Mol Genet 2003;12:1847-63.
122. Zhao Y, Hong DH, Pawlyk B, et al. The retinitis pigmentosa GTPase regulator (RPGR) - interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A 2003;100:3965-70.
123. Raghupathy RK, Zhang X, Liu F, et al. Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish. Sci Rep 2017;7:16881.
124. Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 2000;289:739-45.
125. Sullivan LS, Bowne SJ, Birch DG, et al. Prevalence of disease-causing mutations in families with autosomal dominant retinitis pigmentosa: a screen of known genes in 200 families. Invest Ophthalmol Vis Sci 2006;47:3052-64.
126. Sullivan LS, Bowne SJ, Reeves MJ, et al. Prevalence of mutations in eyeGENE probands with a diagnosis of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci 2013;54:6255-61.
127. Dryja TP, McGee TL, Hahn LB, et al. Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa. N Engl J Med 1990;323:1302-7.
128. Morrow JM, Lazic S, Chang BS. A novel rhodopsin-like gene expressed in zebrafish retina. Vis Neurosci 2011;28:325-35.
129. Morrow JM, Lazic S, Dixon Fox M, et al. A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes. J Exp Biol 2017;220:294-303.
130. Morris AC, Schroeter EH, Bilotta J, Wong RO, Fadool JM. Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafish. Invest Ophthalmol Vis Sci 2005;46:4762-71.
131. Tam BM, Moritz OL, Hurd LB, Papermaster DS. Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis. J Cell Biol 2000;151:1369-80.
132. Kay JN, Roeser T, Mumm JS, et al. Transient requirement for ganglion cells during assembly of retinal synaptic layers. Development 2004;131:1331-42.
133. Fadool JM. Development of a rod photoreceptor mosaic revealed in transgenic zebrafish. Dev Biol 2003;258:277-90.
134. Morris AC, Scholz TL, Brockerhoff SE, Fadool JM. Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol 2008;68:605-19.
135. Morris AC, Forbes-Osborne MA, Pillai LS, Fadool JM. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci 2011;52:2255-66.
136. Babino D, Perkins BD, Kindermann A, Oberhauser V, von Lintig J. The role of 11-cis-retinyl esters in vertebrate cone vision. FASEB J 2015;29:216-26.
137. White DT, Sengupta S, Saxena MT, et al. Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina. Proc Natl Acad Sci U S A 2017;114:E3719-E28.
138. Montgomery JE, Parsons MJ, Hyde DR. A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. J Comp Neurol 2010;518:800-14.
139. Ariga J, Walker SL, Mumm JS. Multicolor time-lapse imaging of transgenic zebrafish: visualizing retinal stem cells activated by targeted neuronal cell ablation. J Vis Exp 2010;(43):2093.
140. Walker SL, Ariga J, Mathias JR, et al. Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One 2012;7:e29916.
141. Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR. Retinal degeneration mutants in the mouse. Vision Res 2002;42:517-25.
142. Olsson JE, Gordon JW, Pawlyk BS, et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 1992;9:815-30.
143. Sakami S, Maeda T, Bereta G, et al. Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem 2011;286:10551-67.
144. Lewin AS, Drenser KA, Hauswirth WW, et al. Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa. Nat Med 1998;4:967-71.
145. Tam BM, Moritz OL. Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2006;47:3234-41.
146. Tam BM, Moritz OL. Dark rearing rescues P23H rhodopsin-induced retinal degeneration in a transgenic Xenopus laevis model of retinitis pigmentosa: a chromophore-dependent mechanism characterized by production of N-terminally truncated mutant rhodopsin. J Neurosci 2007;27:9043-53.
147. Tam BM, Moritz OL. The role of rhodopsin glycosylation in protein folding, trafficking, and light-sensitive retinal degeneration. J Neurosci 2009;29:15145-54.
148. Tam BM, Qazalbash A, Lee HC, Moritz OL. The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation. Invest Ophthalmol Vis Sci 2010;51:1327-34.
149. Santhanam A, Shihabeddin E, Atkinson JA, Nguyen D, Lin YP, O'Brien J. A zebrafish model of retinitis pigmentosa shows continuous degeneration and regeneration of rod photoreceptors. Cells 2020;9:2242.
150. Dryja TP, McGee TL, Reichel E, et al. A point mutation of the rhodopsin gene in one form of retinitis pigmentosa. Nature 1990;343:364-6.
151. Conedera FM, Pousa AMQ, Mercader N, Tschopp M, Enzmann V. Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction. Glia 2019;67:1150-66.
152. Silva NJ, Nagashima M, Li J, et al. Inflammation and matrix metalloproteinase 9 (Mmp-9) regulate photoreceptor regeneration in adult zebrafish. Glia 2020;68:1445-65.
153. Conner C, Ackerman KM, Lahne M, Hobgood JS, Hyde DR. Repressing notch signaling and expressing TNFalpha are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci 2014;34:14403-19.
154. Sahu A, Devi S, Jui J, Goldman D. Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia 2021;69:2882-98.
155. Hoang T, Wang J, Boyd P, et al. Gene regulatory networks controlling vertebrate retinal regeneration. Science 2020;370:eabb8598.
