1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin 2018;68:7-30.

2. Chen W, Zheng R, Baade PD, Zhang S, Zeng H, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016;66:115-32.

3. Siravegna G, Marsoni S, Siena S, Bardelli A. Integrating liquid biopsies into the management of cancer. Nat Rev Clin Oncol 2017;14:531-48.

4. Wan JC, Massie C, Garcia-Corbacho J, Mouliere F, Brenton JD, et al. Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat Rev Cancer 2017;17:223-38.

5. Li W, Zhang X, Lu X, You L, Song Y, et al. 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers. Cell Res 2017;27:1243-57.

6. Xu RH, Wei W, Krawczyk M, Wang W, Luo H, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater 2017;16:1155-61.

7. Zeng C, Stroup EK, Zhang Z, Chiu BC, Zhang W. Towards precision medicine: advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy. Cancer Commun (Lond) 2019;39:12.

8. Cai J, Chen L, Zhang Z, Zhang X, Lu X, et al. Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma. Gut 2019; doi: 10.1136/gutjnl-2019-318882. [Epub ahead of print]

9. Song CX, Yin S, Ma L, Wheeler A, Chen Y, et al. 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res 2017;27:1231-42.

10. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001;61:1659-65.

11. Han D, Lu X, Shih AH, Nie J, You Q, et al. A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. Mol Cell 2016;63:711-9.

12. Song CX, Szulwach KE, Fu Y, Dai Q, Yi C, et al. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 2011;29:68-72.

13. Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, et al. Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature 2018;563:579-83.

14. Gyanchandani R, Kvam E, Heller R, Finehout E, Smith N, et al. Whole genome amplification of cell-free DNA enables detection of circulating tumor DNA mutations from fingerstick capillary blood. Sci Rep 2018;8:17313.

15. Zhang Z, Zhang W. Fragmentation patterns of circulating cell-free DNA demonstrate biomarker potential for human cancers. Biotarget 2019;3:pii:16.

16. Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature 2019;570:385-9.

17. Jiang P, Sun K, Tong YK, Cheng SH, Cheng THT, et al. Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma. Proc Natl Acad Sci U S A 2018;115:E10925-33.

18. Yang Y, Zeng C, Lu X, Song Y, Nie J, et al. 5-Hydroxymethylcytosines in circulating cell-free DNA reveal vascular complications of type 2 diabetes. Clin Chem. Forthcoming 2019.

Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
Follow Us


All published articles are preserved here permanently:


All published articles are preserved here permanently: