REFERENCES
1. Lin, Y. C.; Li, Y. C.; Shangdiar, S.; Chou, F. C.; Sheu, Y. T.; Cheng, P. C. Assessment of PM2.5 and PAH content in PM2.5 emitted from mobile source gasoline-fueled vehicles in concomitant with the vehicle model and mileages. Chemosphere 2019, 226, 502-8.
2. Reizer, E.; Viskolcz, B.; Fiser, B. Formation and growth mechanisms of polycyclic aromatic hydrocarbons: a mini-review. Chemosphere 2022, 291, 132793.
3. Attanayake, C. P.; Hettiarachchi, G. M.; Martin, S.; Pierzynski, G. M. Potential bioavailability of lead, arsenic, and polycyclic aromatic hydrocarbons in compost-amended urban soils. J Environ Qual 2015, 44, 930-44.
4. Gholizadah, S.; Mohammadi, R.; Soleimani, D.; et al. Polycyclic aromatic hydrocarbons in grilled foods from Kermanshah province. Food Addit Contam Part B Surveill 2021, 14, 287-94.
5. Singh, L.; Varshney, J. G.; Agarwal, T. Polycyclic aromatic hydrocarbons’ formation and occurrence in processed food. Food Chem 2016, 199, 768-81.
6. White, A. J.; Bradshaw, P. T.; Herring, A. H.; et al. Exposure to multiple sources of polycyclic aromatic hydrocarbons and breast cancer incidence. Environ Int 2016, 89-90, 185-92.
7. Brandt, H. C.; Watson, W. P. Monitoring human occupational and environmental exposures to polycyclic aromatic compounds. Ann Occup Hyg 2003, 47, 349-78.
8. Li, F.; Xie, L.; Xiao, Q.; et al. Benzo[a]pyrene exposure induces anxiety-like behaviors in the mice through brain metabolic alterations. Sci Total Environ 2024, 954, 176215.
9. Xia, Y.; Cheng, S.; He, J.; et al. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology 2011, 32, 188-98.
10. Liu, Q.; Wang, B.; Wang, Y.; Wang, J.; Xu, Y.; Min, X. Mechanisms by which PM2.5-PAHs drive neurodevelopmental co-morbidities across the placental-blood-brain barrier: a network toxicology analysis. Ecotoxicol Environ Saf 2025, 306, 119306.
11. Fang, Y.; Gong, A. Y.; Haller, S. T.; Dworkin, L. D.; Liu, Z.; Gong, R. The ageing kidney: molecular mechanisms and clinical implications. Ageing Res Rev 2020, 63, 101151.
12. Hommos, M. S.; Glassock, R. J.; Rule, A. D. Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol 2017, 28, 2838-44.
13. Liu, L.; Yuan, X.; Ni, W.; et al. Long-term exposure to low-level ambient air pollution and mortality among 0.3 million Chinese older adults. Biomed Environ Sci 2024, 37, 1362-72.
14. Shi, W.; Li, T.; Zhang, Y.; et al. Association of ambient ozone exposure with anxiety and depression among middle-aged and older adults in China: exploring modification by high temperature. Environ Res Lett 2022, 17, 054010.
15. Fang, E. F.; Fang, Y.; Chen, G.; et al. Adapting health, economic and social policies to address population aging in China. Nat Aging 2025, 5, 2176-87.
16. Huang, Y.; Wang, Y.; Wang, H.; et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry 2019, 6, 211-24.
17. Fang, E. F.; Scheibye-Knudsen, M.; Jahn, H. J.; et al. A research agenda for aging in China in the 21st century. Ageing Res Rev 2015, 24, 197-205.
18. Zhou, P.; Wang, S.; Yan, Y.; et al. Association between chronic diseases and depression in the middle-aged and older adult Chinese population-a seven-year follow-up study based on CHARLS. Front Public Health 2023, 11, 1176669.
19. Yunming, L.; Changsheng, C.; Haibo, T.; et al. Prevalence and risk factors for depression in older people in Xi’an China: a community-based study. Int J Geriatr Psychiatry 2012, 27, 31-9.
20. Ma, Y.; Xiang, Q.; Yan, C.; Liao, H.; Wang, J. Relationship between chronic diseases and depression: the mediating effect of pain. BMC Psychiatry 2021, 21, 436.
21. Fang, M.; Mirutse, G.; Guo, L.; Ma, X. Role of socioeconomic status and housing conditions in geriatric depression in rural China: a cross-sectional study. BMJ Open 2019, 9, e024046.
22. Koskinen, M. K.; Hovatta, I. Genetic insights into the neurobiology of anxiety. Trends Neurosci 2023, 46, 318-31.
23. Kris-Etherton, P. M.; Petersen, K. S.; Hibbeln, J. R.; et al. Nutrition and behavioral health disorders: depression and anxiety. Nutr Rev 2021, 79, 247-60.
24. McElhany, K.; Aggarwal, S.; Wood, G.; Beauchamp, J. Protective and harmful social and psychological factors associated with mood and anxiety disorders in perimenopausal women: a narrative review. Maturitas 2024, 190, 108118.
25. Rautio, N.; Filatova, S.; Lehtiniemi, H.; Miettunen, J. Living environment and its relationship to depressive mood: a systematic review. Int J Soc Psychiatry 2018, 64, 92-103.
26. Yang, T.; Wang, J.; Huang, J.; Kelly, F. J.; Li, G. Long-term exposure to multiple ambient air pollutants and association with incident depression and anxiety. JAMA Psychiatry 2023, 80, 305-13.
27. Wray, N. R.; Ripke, S.; Mattheisen, M.; et al.; eQTLGen, 23andMe, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 2018, 50, 668-81.
28. Braithwaite, I.; Zhang, S.; Kirkbride, J. B.; Osborn, D. P. J.; Hayes, J. F. Air pollution (particulate matter) exposure and associations with depression, anxiety, bipolar, psychosis and suicide risk: a systematic review and meta-analysis. Environ Health Perspect 2019, 127, 126002.
29. Fan, S. J.; Heinrich, J.; Bloom, M. S.; et al. Ambient air pollution and depression: a systematic review with meta-analysis up to 2019. Sci Total Environ 2020, 701, 134721.
30. Guo, J.; Garshick, E.; Si, F.; et al. Environmental toxicant exposure and depressive symptoms. JAMA Netw Open 2024, 7, e2420259.
31. Niedzwiecki, M. M.; Rosa, M. J.; Solano-González, M.; et al. Particulate air pollution exposure during pregnancy and postpartum depression symptoms in women in Mexico City. Environ Int 2020, 134, 105325.
32. Vert, C.; Sánchez-Benavides, G.; Martínez, D.; et al. Effect of long-term exposure to air pollution on anxiety and depression in adults: a cross-sectional study. Int J Hyg Environ Health 2017, 220, 1074-80.
33. Rahman, H. H.; Niemann, D.; Munson-McGee, S. H. Association among urinary polycyclic aromatic hydrocarbons and depression: a cross-sectional study from NHANES 2015-2016. Environ Sci Pollut Res Int 2022, 29, 13089-97.
34. Shiue, I. Urinary heavy metals, phthalates and polyaromatic hydrocarbons independent of health events are associated with adult depression: USA NHANES, 2011-2012. Environ Sci Pollut Res Int 2015, 22, 17095-103.
35. Zhang, L.; Sun, J.; Zhang, D. The relationship between urine polycyclic aromatic hydrocarbons and depressive symptoms in American adults. J Affect Disord 2021, 292, 227-33.
36. Margolis, A. E.; Herbstman, J. B.; Davis, K. S.; et al. Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence. J Child Psychol Psychiatry 2016, 57, 851-60.
37. Perera, F. P.; Tang, D.; Wang, S.; et al. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environ Health Perspect 2012, 120, 921-6.
38. Perera, F. P.; Wang, S.; Vishnevetsky, J.; et al. Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children. Environ Health Perspect 2011, 119, 1176-81.
39. Zhen, H.; Zhang, F.; Cheng, H.; et al. Association of polycyclic aromatic hydrocarbons exposure with child neurodevelopment and adult emotional disorders: a meta-analysis study. Ecotoxicol Environ Saf 2023, 255, 114770.
40. Zhen, H.; Jia, Y.; Zhu, B.; et al. Associations of polycyclic aromatic hydrocarbons exposure with perinatal anxiety symptoms. BMC Public Health 2025, 25, 1245.
41. DeSerisy, M.; Salas, L.; Akhundova, E.; et al. Polycyclic aromatic hydrocarbon exposure effects on trajectories of maternal and adolescent mental health. Child Adolesc Psychiatry Ment Health 2024, 18, 114.
42. Kim, S.; Carson, K. A.; Chien, A. L. The association between urinary polycyclic aromatic hydrocarbon metabolites and atopic triad by age and body weight in the US population. J Dermatolog Treat 2022, 33, 2488-94.
43. Gao, Y.; Wang, B.; Hua, L.; et al. Risk assessment and exposure patterns of hydroxypolycyclic aromatic hydrocarbons in elderly population: insights from urinary metabolite levels and dietary habits. J Environ Sci 2026, 163, 37-47.
44. Hua, L.; Guo, S.; Wang, Y.; Sun, H.; Zhao, H. Simultaneous determination of multiple isomeric hydroxylated polycyclic aromatic hydrocarbons in urine by using ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2021, 1184, 122983.
45. Hua, L.; Gao, Y.; Guo, S.; et al. Urinary metabolites of polycyclic aromatic hydrocarbons of rural population in Northwestern China: oxidative stress and health risk assessment. Environ Sci Technol 2024, 58, 7758-69.
46. Wang, X. Q.; Wang, Y. X.; Ye, Z. H.; Zhang, Z. L.; Pan, X.; Wang, X. C. The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study. Front Psychiatry 2026, 17, 1783363.
48. Janati Idrissi, A.; Lamkaddem, A.; Benouajjit, A.; et al. Sleep quality and mental health in the context of COVID-19 pandemic and lockdown in Morocco. Sleep Med 2020, 74, 248-53.
49. Yesavage, J. A.; Brink, T. L.; Rose, T. L.; et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982, 17, 37-49.
50. Ma, H.; Gao, X.; Chen, H.; et al. Depressive symptoms status and nighttime sleep duration in relation to cognitive performance in Chinese elderly: insights from a large cross-sectional inquiry. J Affect Disord 2026, 401, 121231.
51. Zhao, T.; Liu, R.; Han, Q.; et al. Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis. Aging Clin Exp Res 2024, 36, 165.
52. Guo, J.; Ye, K. X.; Lee, T. S.; et al. Depression, but not anxiety, is associated with epigenetic age accelerations among Asian older adults. Mol Psychiatry 2026, 31, 4690-8.
53. Dias, F. L. D. C.; Teixeira, A. L.; Guimarães, H. C.; et al. Accuracy of the 15-item Geriatric Depression Scale (GDS-15) in a community-dwelling oldest-old sample: the Pietà Study. Trends Psychiatry Psychother 2017, 39, 276-9.
54. Marc, L. G.; Raue, P. J.; Bruce, M. L. Screening performance of the 15-item geriatric depression scale in a diverse elderly home care population. Am J Geriatr Psychiatry 2008, 16, 914-21.
55. Cui, S.; Wu, J.; Li, X.; et al. Association between polycyclic aromatic hydrocarbons and anxiety in US adults: National Health and Nutrition Examination Survey (NHANES) 2007 to 2012. Medicine 2025, 104, e42900.
56. Drafting Committee of Chinese Consensus on Overweight/Obesity Medical Nutrition Therapy. Chinese consensus on overweight/obesity medical nutrition therapy (2016). Chin J Diabetes Mellitus 2016, 8, 525-40.
57. Dutta, K.; Ghosh, D.; Nazmi, A.; Kumawat, K. L.; Basu, A. A common carcinogen benzo[a]pyrene causes neuronal death in mouse via microglial activation. PLoS One 2010, 5, e9984.
58. Saunders, C. R.; Das, S. K.; Ramesh, A.; Shockley, D. C.; Mukherjee, S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. J Appl Toxicol 2006, 26, 427-38.
59. León-Mejía, G.; Quintana, M.; Debastiani, R.; et al. Genetic damage in coal miners evaluated by buccal micronucleus cytome assay. Ecotoxicol Environ Saf 2014, 107, 133-9.
60. Wei, Y.; Han, I. K.; Hu, M.; Shao, M.; Zhang, J. J.; Tang, X. Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans. Chemosphere 2010, 81, 1280-5.
61. Jeon, S. W.; Kim, Y. K. Inflammation-induced depression: Its pathophysiology and therapeutic implications. J Neuroimmunol 2017, 313, 92-8.
62. Peirce, J. M.; Alviña, K. The role of inflammation and the gut microbiome in depression and anxiety. J Neurosci Res 2019, 97, 1223-41.
63. Qiu, J.; Liu, R.; Ma, Y.; et al. Lipopolysaccharide-induced depression-like behaviors is ameliorated by sodium butyrate via inhibiting neuroinflammation and oxido-nitrosative stress. Pharmacology 2020, 105, 550-60.
64. Cheng, Y. Y.; Yao, Q.; Miao, Y.; Guan, W. Metformin as a potential antidepressant: mechanisms and therapeutic insights in depression. Biochem Pharmacol 2025, 233, 116773.
65. Ohrmann, P.; Pedersen, A.; Braun, M.; et al. Effect of gender on processing threat-related stimuli in patients with panic disorder: sex does matter. Depress Anxiety 2010, 27, 1034-43.
66. Lungu, O.; Potvin, S.; Tikàsz, A.; Mendrek, A. Sex differences in effective fronto-limbic connectivity during negative emotion processing. Psychoneuroendocrinology 2015, 62, 180-8.
67. Tao, C.; Zhang, G. W.; Huang, J. J.; Li, Z.; Tao, H. W.; Zhang, L. I. The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections. Nat Neurosci 2023, 26, 1529-40.
68. Homan, P. Structural sexism and health in the United States: a new perspective on health inequality and the gender system. Am Sociol Rev 2019, 84, 486-516.
69. Srivastava, N.; Anand, M. Understanding gender and mental health. In Gender and mental health. Anand, M.; Ed.; Singapore: Springer; 2020. pp. 3-17.
70. Jin, Z.; Sun, W.; Wang, G. Association between polycyclic aromatic hydrocarbons exposure and current asthma: a population-based study. BMC Public Health 2025, 25, 53.
71. Peris-Camarasa, B.; Pardo, O.; Fernández, S. F.; Dualde, P.; Coscollà, C. Risk assessment and predictors of the exposure to polycyclic aromatic hydrocarbons in Spanish adults by urinary human biomonitoring. Chemosphere 2024, 352, 141330.
72. Peng, M.; Lu, S.; Yu, Y.; et al. Urinary monohydroxylated polycyclic aromatic hydrocarbons in primiparas from Shenzhen, South China: Levels, risk factors, and oxidative stress. Environ Pollut 2020, 259, 113854.
73. Chen, B.; Hu, Y.; Zheng, L.; Wang, Q.; Zhou, Y.; Jin, T. Urinary 1-hydroxypyrene concentrations in Chinese coke oven workers relative to job category, respirator usage, and cigarette smoking. Am J Ind Med 2007, 50, 657-63.
74. Abdel-Shafy, H. I.; Mansour, M. S. A review on polycyclic aromatic hydrocarbons: source, environmental impact, effect on human health and remediation. Egypt J Pet 2016, 25, 107-23.
75. Pastor-Belda, M.; Campillo, N.; Arroyo-Manzanares, N.; et al. Bioaccumulation of polycyclic aromatic hydrocarbons for forensic assessment using gas chromatography-mass spectrometry. Chem Res Toxicol 2019, 32, 1680-8.
76. Zhang, Y.; Hu, Q.; Fu, J.; Li, X.; Mao, H.; Wang, T. Influence of exposure pathways on tissue distribution and health impact of polycyclic aromatic hydrocarbon derivatives. Environ Health 2023, 1, 150-67.
77. De Roos, A. J.; Ulrich, C. M.; Sjodin, A.; McTiernan, A. Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations. J Expo Sci Environ Epidemiol 2012, 22, 617-24.
78. Gupta, H.; Bhandari, U. Molecular insight into obesity-associated nephropathy: clinical implications and possible strategies for its management. Curr Drug Targets 2025, 26, 188-202.
79. D’Agati, V. D.; Chagnac, A.; de Vries, A. P.; et al. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol 2016, 12, 453-71.
80. Beurel, E.; Toups, M.; Nemeroff, C. B. The bidirectional relationship of depression and inflammation: double trouble. Neuron 2020, 107, 234-56.
81. Schleh, M. W.; Caslin, H. L.; Garcia, J. N.; et al. Metaflammation in obesity and its therapeutic targeting. Sci Transl Med 2023, 15, eadf9382.
