REFERENCES
1. Siegel, R. L.; Giaquinto, A. N.; Jemal, A. Cancer statistics, 2024. CA. Cancer. J. Clin. 2024, 74, 12-49.
2. Gatta, G.; Botta, L.; Rossi, S.; et al.; EUROCARE Working Group. Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5 - a population-based study. Lancet. Oncol. 2014, 15, 35-47.
3. Wu, Y.; Deng, Y.; Wei, B.; et al. Global, regional, and national childhood cancer burden, 1990-2019: an analysis based on the Global Burden of Disease Study 2019. J. Adv. Res. 2022, 40, 233-47.
4. Atun, R.; Bhakta, N.; Denburg, A.; et al. Sustainable care for children with cancer: a Lancet Oncology Commission. Lancet. Oncol. 2020, 21, e185-224.
5. Spector, L. G.; Pankratz, N.; Marcotte, E. L. Genetic and nongenetic risk factors for childhood cancer. Pediatr. Clin. North. Am. 2015, 62, 11-25.
6. Abalo, K. D.; Rage, E.; Leuraud, K.; et al. Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis. Pediatr. Radiol. 2021, 51, 45-56.
7. Persson, M. S. M.; Yin, W.; Döring, N.; et al. Gestational age and cancer risk up to young adulthood in Swedish population born 1974 to 2013: a population-based cohort study. Int. J. Cancer. 2022, 150, 1269-80.
8. Rogne, T.; Wang, R.; Wang, P.; et al. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. Lancet. Planet. Health. 2024, 8, e506-14.
9. Perkins-Kirkpatrick, S. E.; Lewis, S. C. Increasing trends in regional heatwaves. Nat. Commun. 2020, 11, 3357.
10. Blunden, J.; Boyer, T. State of the Climate in 2021. Bull. Am. Meteorol. Soc. 2022, 103, S1-465.
11. Cohen, J.; Agel, L.; Barlow, M.; Garfinkel, C. I.; White, I. Linking Arctic variability and change with extreme winter weather in the United States. Science 2021, 373, 1116-21.
12. Romanello, M.; di Napoli, C.; Green, C.; et al. The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms. Lancet 2023, 402, 2346-94.
13. Tsuzuki-Hayakawa, K.; Tochihara, Y.; Ohnaka, T. Thermoregulation during heat exposure of young children compared to their mothers. Eur. J. Appl. Physiol. Occup. Physiol. 1995, 72, 12-7.
14. Xu, R.; Li, S.; Guo, S.; et al. Environmental temperature and human epigenetic modifications: a systematic review. Environ. Pollut. 2020, 259, 113840.
15. Vicedo-Cabrera, A. M.; Sera, F.; Guo, Y.; et al. A multi-country analysis on potential adaptive mechanisms to cold and heat in a changing climate. Environ. Int. 2018, 111, 239-46.
16. Liu, Q.; Wang, H.; Chen, Z.; et al. Global, regional, and national epidemiology of nasopharyngeal carcinoma in middle-aged and elderly patients from 1990 to 2021. Ageing. Res. Rev. 2025, 104, 102613.
17. Nong, J.; Su, C.; Li, C.; et al. Global, regional, and national epidemiology of childhood neuroblastoma (1990-2021): a statistical analysis of incidence, mortality, and DALYs. EClinicalMedicine 2025, 79, 102964.
18. Bo, Y.; Zhu, Y.; Lu, R.; et al. Burden of stroke attributable to high ambient temperature from 1990 to 2019: a global analysis. Int. J. Stroke. 2023, 18, 1121-31.
19. Zhao, Q.; Guo, Y.; Ye, T.; et al. Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study. Lancet. Planet. Health. 2021, 5, e415-25.
20. Gasparrini, A.; Guo, Y.; Hashizume, M.; et al. Mortality risk attributable to high and low ambient temperature: a multicountry observational study. Lancet 2015, 386, 369-75.
21. GBD 2017 Childhood Cancer Collaborators. The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017. Lancet. Oncol. 2019, 20, 1211-25.
22. Abdul-Sater, Z.; Mukherji, D.; Adib, S. M.; et al. Cancer registration in the Middle East, North Africa, and Turkey (MENAT) region: a tale of conflict, challenges, and opportunities. Front. Oncol. 2022, 12, 1050168.
23. Abdul-Sater, Z.; Shamseddine, A.; Taher, A.; et al.; ICRIM. Cancer registration in the Middle East, North Africa, and Turkey: scope and challenges. JCO. Glob. Oncol. 2021, 7, 1101-9.
24. Ward, Z. J.; Yeh, J. M.; Bhakta, N.; Frazier, A. L.; Atun, R. Estimating the total incidence of global childhood cancer: a simulation-based analysis. Lancet. Oncol. 2019, 20, 483-93.
25. Rousi, E.; Kornhuber, K.; Beobide-Arsuaga, G.; Luo, F.; Coumou, D. Accelerated western European heatwave trends linked to more-persistent double jets over Eurasia. Nat. Commun. 2022, 13, 3851.
26. García-León, D.; Casanueva, A.; Standardi, G.; Burgstall, A.; Flouris, A. D.; Nybo, L. Current and projected regional economic impacts of heatwaves in Europe. Nat. Commun. 2021, 12, 5807.
27. Kumar, P.; Rai, A.; Upadhyaya, A.; Chakraborty, A. Analysis of heat stress and heat wave in the four metropolitan cities of India in recent period. Sci. Total. Environ. 2022, 818, 151788.
28. Sharma, S.; Mujumdar, P. Increasing frequency and spatial extent of concurrent meteorological droughts and heatwaves in India. Sci. Rep. 2017, 7, 15582.
29. Watts, N.; Amann, M.; Arnell, N.; et al. The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate. Lancet 2019, 394, 1836-78.
30. Greaves, M. A causal mechanism for childhood acute lymphoblastic leukaemia. Nat. Rev. Cancer. 2018, 18, 471-84.
31. Ebi, K. L.; Capon, A.; Berry, P.; et al. Hot weather and heat extremes: health risks. Lancet 2021, 398, 698-708.
33. Prada, D.; Baccarelli, A. A.; Kupsco, A.; Parks, R. M. Climate change and health: understanding mechanisms will inform mitigation and prevention strategies. Nat. Med. 2024, 30, 1522-4.
34. He, J. R.; Yu, Y.; Fang, F.; et al. Evaluation of maternal infection during pregnancy and childhood leukemia among offspring in Denmark. JAMA. Netw. Open. 2023, 6, e230133.
35. Whitehead, T. P.; Wiemels, J. L.; Zhou, M.; et al. Cytokine levels at birth in children who developed acute lymphoblastic leukemia. Cancer. Epidemiol. Biomarkers. Prev. 2021, 30, 1526-35.
36. Timms, J. A.; Relton, C. L.; Sharp, G. C.; Rankin, J.; Strathdee, G.; McKay, J. A. Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia. Int. J. Cancer. 2019, 145, 2933-43.
37. Seki, T.; Yang, Y.; Sun, X.; et al. Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature 2022, 608, 421-8.
38. Souyris, M.; Mejía, J. E.; Chaumeil, J.; Guéry, J. C. Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation. Semin. Immunopathol. 2019, 41, 153-64.
39. Laffont, S.; Rouquié, N.; Azar, P.; et al. X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-α production of plasmacytoid dendritic cells from women. J. Immunol. 2014, 193, 5444-52.
40. Klein, S. L.; Flanagan, K. L. Sex differences in immune responses. Nat. Rev. Immunol. 2016, 16, 626-38.
41. GBD 2021 Risk Factors Collaborators. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 2024, 403, 2162-203.
42. Perera, F. Pollution from fossil-fuel combustion is the leading environmental threat to global pediatric health and equity: solutions exist. Int. J. Environ. Res. Public. Health. 2017, 15, 16.
43. Spector, L. G.; Birch, J. The epidemiology of hepatoblastoma. Pediatr. Blood. Cancer. 2012, 59, 776-9.
44. Czauderna, P.; Haeberle, B.; Hiyama, E.; et al. The Children’s Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model. Eur. J. Cancer. 2016, 52, 92-101.
