fig8

Figure 8. OVs-rich bimetallic oxide FeWO_x nanosheets as peroxidase-like nanozyme for cancer multimodal imaging. (A) Design schematic; (B) Time-dependent TMB oxidation by FeWO_x-PEG (0.5 mM) and H₂O₂ (100 μM); (C) PA imaging scheme for subcutaneous tumors; (D) In vivo ratiometric PA imaging of tumors post FeTIR injection; (E) PA900/PA800 ratios in tumors at various time points; (F) PA imaging scheme for LPS-induced inflammation; (G) Ratiometric PA imaging of inflamed tissues; (H) PA900/PA800 ratios in inflammation over time. (Reproduced with permission^[122]. Copyright 2020, Wiley). ^***P < 0.001. OVs: Oxygen vacancies; PEG: polyethylene glycol; PA: photoacoustic; MR: magnetic resonance; FeTIR: FeWO_x-PEG@TMB@IR780; LPS: lipopolysaccharide.