scheme1

Catalyst-free decarboxylative alkylation: access to quaternary center

Scheme 1. (A) Amidation reaction between amines and carboxylic acids; (B) esterification reaction between carboxylic acids and amine-derived pyridinium salts; (C) this work: decarboxylative alkylation reaction. TPT: 2,4,6-triphenylpyrylium; DMSO: Dimethyl sulfoxide; RT: room temperature.

Chemical Synthesis
ISSN 2769-5247 (Online)

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