REFERENCES
1. Alberico SL, Cassell MD, Narayanan NS. The vulnerable ventral tegmental area in Parkinson’s disease. Basal Ganglia. 2015;5:51-5.
2. Przedborski S. The two-century journey of Parkinson disease research. Nat Rev Neurosci. 2017;18:251-9.
3. Fu Y, Paxinos G, Watson C, Halliday GM. The substantia nigra and ventral tegmental dopaminergic neurons from development to degeneration. J Chem Neuroanat. 2016;76:98-107.
4. Weisenhorn DM, Giesert F, Wurst W. Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson’s disease. J Neurochem. 2016;139 Suppl 1:8-26.
5. Liu G, Yu J, Ding J, et al. Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. J Clin Invest. 2014;124:3032-46.
6. Cai H, Liu G, Sun L, Ding J. Aldehyde dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease. Transl Neurodegener. 2014;3:27.
7. Carmichael K, Evans RC, Lopez E, et al. Function and regulation of ALDH1A1-positive nigrostriatal dopaminergic neurons in motor control and Parkinson’s disease. Front Neural Circuits. 2021;15:644776.
8. Casida JE, Ford B, Jinsmaa Y, Sullivan P, Cooney A, Goldstein DS. Benomyl, aldehyde dehydrogenase, DOPAL, and the catecholaldehyde hypothesis for the pathogenesis of Parkinson’s disease. Chem Res Toxicol. 2014;27:1359-61.
9. Poulin JF, Zou J, Drouin-Ouellet J, Kim KY, Cicchetti F, Awatramani RB. Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling. Cell Rep. 2014;9:930-43.
10. Carmichael K, Sullivan B, Lopez E, Sun L, Cai H. Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson’s disease. Ageing Neur Dis. 2021;1:4.
11. Gaertner Z, Azcorra M, Dombeck DA, Awatramani R. Molecular heterogeneity in the substantia nigra: a roadmap for understanding PD motor pathophysiology. Neurobiol Dis. 2022;175:105925.
12. Poulin JF, Gaertner Z, Moreno-Ramos OA, Awatramani R. Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches. Trends Neurosci. 2020;43:155-69.
13. Goldstein DS. Biomarkers, mechanisms, and potential prevention of catecholamine neuron loss in Parkinson disease. Adv Pharmacol. 2013;68:235-72.
14. Hegarty SV, Sullivan AM, O’Keeffe GW. Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development. Dev Biol. 2013;379:123-38.
15. Parkinson J. An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci. 2002;14:223-36; discussion 222.
16. Wu J, Kung J, Dong J, et al. Distinct connectivity and functionality of aldehyde dehydrogenase 1A1-positive nigrostriatal dopaminergic neurons in motor learning. Cell Rep. 2019;28:1167-1181.e7.
17. Azcorra M, Gaertner Z, Davidson C, et al. Unique functional responses differentially map onto genetic subtypes of dopamine neurons. Nat Neurosci. 2023;26:1762-74.
18. Poulin JF, Caronia G, Hofer C, et al. Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches. Nat Neurosci. 2018;21:1260-71.
19. Madisen L, Zwingman TA, Sunkin SM, et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010;13:133-40.
20. Pei Y, Rogan SC, Yan F, Roth BL. Engineered GPCRs as tools to modulate signal transduction. Physiology. 2008;23:313-21.
21. Fenno LE, Ramakrishnan C, Kim YS, et al. Comprehensive dual- and triple-feature intersectional single-vector delivery of diverse functional payloads to cells of behaving mammals. Neuron. 2020;107:836-853.e11.
22. Liu Z, Yang N, Dong J, et al. Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction. Nat Commun. 2022;13:3490.
23. Bonaventura J, Eldridge MAG, Hu F, et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019;10:4627.
24. Matikainen-Ankney BA, Earnest T, Ali M, et al. An open-source device for measuring food intake and operant behavior in rodent home-cages. Elife. 2021;10:e66173.
25. Costa RM, Cohen D, Nicolelis MA. Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Curr Biol. 2004;14:1124-34.
27. Coddington LT, Dudman JT. Learning from action: reconsidering movement signaling in midbrain dopamine neuron activity. Neuron. 2019;104:63-77.
28. Yin HH, Ostlund SB, Knowlton BJ, Balleine BW. The role of the dorsomedial striatum in instrumental conditioning. Eur J Neurosci. 2005;22:513-23.
29. Thorn CA, Atallah H, Howe M, Graybiel AM. Differential dynamics of activity changes in dorsolateral and dorsomedial striatal loops during learning. Neuron. 2010;66:781-95.
30. Yin HH, Knowlton BJ. The role of the basal ganglia in habit formation. Nat Rev Neurosci. 2006;7:464-76.
31. Yaghmaeian Salmani B, Lahti L, Gillberg L, et al. Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model. Elife. 2024;12:RP89482.
32. Martirosyan A, Ansari R, Pestana F, et al. Unravelling cell type-specific responses to Parkinson’s disease at single cell resolution. Mol Neurodegener. 2024;19:7.
