REFERENCES
2. Wang CY, Meynard D, Lin HY. The role of TMPRSS6/matriptase-2 in iron regulation and anemia. Front Pharmacol. 2014;5:114.
3. Ganz T, Nemeth E, Rivella S, et al. TMPRSS6 as a therapeutic target for disorders of erythropoiesis and iron homeostasis. Adv Ther. 2023;40:1317-33.
5. De Falco L, Sanchez M, Silvestri L, et al. Iron refractory iron deficiency anemia. Haematologica. 2013;98:845-53.
6. Park TJ, Lee YJ, Kim HJ, Park HG, Park WJ. Cloning and characterization of TMPRSS6, a novel type 2 transmembrane serine protease. Mol Cells. 2005;19:223-7.
7. Varga E, Pap R, Jánosa G, Sipos K, Pandur E. IL-6 regulates hepcidin expression via the BMP/SMAD pathway by altering BMP6, TMPRSS6 and TfR2 expressions at normal and inflammatory conditions in BV2 microglia. Neurochem Res. 2021;46:1224-38.
8. Zuo Y, Bai J, Bai H, et al. Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth. Cell Death Dis. 2024;15:49.
9. de Haas EN, Pértille F, Kjaer JB, Jensen P, Guerrero-Bosagna C. Genetic and neuro-epigenetic effects of divergent artificial selection for feather pecking behaviour in chickens. BMC Genomics. 2024;25:1219.
10. Denver P, English A, McClean PL. Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice. Brain Behav Immun. 2018;70:423-34.
11. Zhang Y, Chen H, Li R, Sterling K, Song W. Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future. Signal Transduct Target Ther. 2023;8:248.
12. Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine. 2019;14:5541-54.
13. Barton SM, To E, Rogers BP, et al. Inhalable thioflavin S for the detection of amyloid beta deposits in the retina. Molecules. 2021;26:835.
14. Xue Q, Yan D, Chen X, et al. Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 2023;19:1982-96.
15. Liao P, Wang W, Wang W, et al. CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40:365-78.e6.
16. Li X, Chen J, Feng W, et al. Berberine ameliorates iron levels and ferroptosis in the brain of 3 × Tg-AD mice. Phytomedicine. 2023;118:154962.
17. Candelaria PV, Leoh LS, Penichet ML, Daniels-Wells TR. Antibodies targeting the transferrin receptor 1 (TfR1) as direct anti-cancer agents. Front Immunol. 2021;12:607692.
18. Park E, Chung SW. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death Dis. 2019;10:822.
19. Finberg KE, Whittlesey RL, Fleming MD, Andrews NC. Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood. 2010;115:3817-26.
21. Tian S, Wang B, Ding Y, et al. The role of iron transporters and regulators in Alzheimer’s disease and Parkinson’s disease: pathophysiological insights and therapeutic prospects. Biomed Pharmacother. 2024;179:117419.
22. Naderi S, Khodagholi F, Janahmadi M, et al. Ferroptosis and cognitive impairment: unraveling the link and potential therapeutic targets. Neuropharmacology. 2025;263:110210.
23. Li ZD, Li H, Kang S, et al. The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice. Cell Death Dis. 2022;13:1006.
24. Rouault TA. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol. 2006;2:406-14.
25. Urrutia PJ, Hirsch EC, González-Billault C, Núñez MT. Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia. J Neurochem. 2017;142:140-52.
26. You L, Yu PP, Dong T, et al. Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells. Cell Death Dis. 2022;13:667.
