REFERENCES
1. Putzke JD, Whaley NR, Baba Y, Wszolek ZK, Uitti RJ. Essential tremor: predictors of disease progression in a clinical cohort. J Neurol Neurosurg Psychiatry 2006;77:1235-7.
2. Louis ED, Agnew A, Gillman A, Gerbin M, Viner AS. Estimating annual rate of decline: prospective, longitudinal data on arm tremor severity in two groups of essential tremor cases. J Neurol Neurosurg Psychiatry 2011;82:761-5.
3. Louis ED, Michalec M, Gillman A. Shaky drawing: what is the rate of decline during prospective follow-up of essential tremor? BMJ Open 2014;4:e004626.
4. Louis ED, Jurewicz EC, Watner D. Community-based data on associations of disease duration and age with severity of essential tremor: implications for disease pathophysiology. Mov Disord 2003;18:90-3.
5. Gutierrez J, Park J, Badejo O, Louis ED. Worse and worse and worse: essential tremor patients' longitudinal perspectives on their condition. Front Neurol 2016;7:175.
6. McGurn MM, Berry DS, Dworkin JD, Louis ED. Longitudinal progression of essential tremor: do tremor severity scores increase at a uniform rate? Front Neurol 2022;13:871905.
7. Louis ED, Nguyen D, Ghanem A. Reliability of self-report data on age of onset in essential tremor: data from a prospective, longitudinal cohort. Neuroepidemiology 2023;57:7-13.
8. Angelini L, Paparella G, De Biase A, et al. Longitudinal study of clinical and neurophysiological features in essential tremor. Eur J Neurol 2023;30:631-40.
9. Louis ED. When do essential tremor patients develop head tremor? influences of age and duration and evidence of a biological clock. Neuroepidemiology 2013;41:110-5.
10. Prasad S, Bhalsing KS, Jhunjhunwala K, Lenka A, Binu VS, Pal PK. Phenotypic variability of essential tremor based on the age at onset. Can J Neurol Sci 2019;46:192-8.
11. Chen W, Hopfner F, Szymczak S, et al. Topography of essential tremor. Parkinsonism Relat Disord 2017;40:58-63.
12. Poston KL, Rios E, Louis ED. Action tremor of the legs in essential tremor: prevalence, clinical correlates, and comparison with age-matched controls. Parkinsonism Relat Disord 2009;15:602-5.
13. Kestenbaum M, Michalec M, Yu Q, Pullman SL, Louis ED. Intention tremor of the legs in essential tremor: prevalence and clinical correlates. Mov Disord Clin Pract 2015;2:24-8.
15. Hopfner F, Ahlf A, Lorenz D, et al. Early- and late-onset essential tremor patients represent clinically distinct subgroups. Mov Disord 2016;31:1560-6.
16. Gironell A, Ribosa-Nogue R, Gich I, Marin-Lahoz J, Pascual-Sedano B. Severity stages in essential tremor: a long-term retrospective study using the glass scale. Tremor Other Hyperkinet Mov 2015;5:299.
17. Louis ED, Faust PL, Vonsattel JP, et al. Older onset essential tremor: more rapid progression and more degenerative pathology. Mov Disord 2009;24:1606-12.
18. Deuschl G, Petersen I, Lorenz D, Christensen K. Tremor in the elderly: essential and aging-related tremor. Mov Disord 2015;30:1327-34.
19. Louis ED, Benito-Leon J, Ottman R, Bermejo-Pareja F. Neurological Disorders in Central Spain Study G. A population-based study of mortality inessential tremor. Neurology 2007;69:1982-9.
20. Jankovic J, Beach J, Schwartz K, Contant C. Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects. Neurology 1995;45:645-8.
21. Louis ED, Ottman R. Study of possible factors associated with age of onset in essential tremor. Mov Disord 2006;21:1980-6.
22. Louis ED, Clark LN, Ottman R. Familial versus sporadic essential tremor: what patterns can one decipher in age of onset? Neuroepidemiology 2015;44:166-72.
23. Louis ED, Hernandez N, Rabinowitz D, Ottman R, Clark LN. Predicting age of onset in familial essential tremor: how much does age of onset run in families? Neuroepidemiology 2013;40:269-73.
24. Knudsen K, Lorenz D, Deuschl G. A clinical test for the alcohol sensitivity of essential tremor. Mov Disord 2011;26:2291-5.
25. Hopfner F, Erhart T, Knudsen K, et al. Testing for alcohol sensitivity of tremor amplitude in a large cohort with essential tremor. Parkinsonism Relat Disord 2015;21:848-51.
26. Bellows ST, Jankovic J. Phenotypic features of isolated essential tremor, essential tremor plus, and essential tremor-parkinson's disease in a movement disorders clinic. Tremor Other Hyperkinet Mov 2021;11:12.
27. Bhatia KP, Bain P, Bajaj N, et al. Consensus statement on the classification of tremors. from the task force on tremor of the international parkinson and movement disorder society. Mov Disord 2018;33:75-87.
28. Elble RJ. Do we belittle essential tremor by calling it a syndrome rather than a disease? Front Neurol 2020;11:586606.
30. Lenka A, Louis ED. Do we belittle essential tremor by calling it a syndrome rather than a disease? Front Neurol 2020;11:522687.
31. Louis ED, Bares M, Benito-Leon J, et al. Essential tremor-plus: a controversial new concept. Lancet Neurol 2020;19:266-70.
32. Louis ED, Huey ED, Cosentino S. Features of "ET plus" correlate with age and tremor duration:"ET plus" maybe a disease stage rather than a subtype of essential tremor. Parkinsonism Relat Disord 2021;91:42-7.
33. Iglesias-Hernandez D, Delgado N, McGurn M, Huey ED, CosentinoS, Louis ED. "ET Plus": instability of the diagnosis during prospective longitudinal follow-up of essential tremor cases. Front Neurol 2021;12:782694.
34. Rajalingam R, Breen DP, Lang AE, Fasano A. Essential tremor plus is more common than essential tremor: Insights from thereclassification of a cohort of patients with lower limb tremor. Parkinsonism Relat Disord 2018;56:109- 10.
35. Lolekha P, Dharmasaroja P, Uransilp N, Sukphulloprat P, MuengtaweepongsaS, Kulkantrakorn K. The differences in clinical characteristics and natural history between essential tremor and essential tremor plus. Sci Rep 2022;12:7669.
36. Peng J, Li N, Li J, et al. Reclassification of patients with tremor syndrome and comparisons of essential tremor and essential tremor-plus patients. J Neurol 2022;269:3653-62.
37. Sun Q, He R, Huang H, et al. Age and sex affect essential tremor (ET) plus: clinical heterogeneity in ET based on the national survey in china. Aging Dis 2022;14:1360-73.
38. Erro R, Pilotto A, Magistrelli L, et al. A Bayesian approach to essential tremor plus: a preliminary analysis of the TITAN cohort. Parkinsonism Relat Disord 2022;103:73-6.
39. Louis ED, McCreary M. How common is essential tremor? update on the worldwide prevalence of essential tremor. Tremor Other Hyperkinet Mov 2021;11:28.
40. Louis ED, Factor-Litvak P. Screening for and estimating the prevalence of essential tremor: a random-digit dialing-based study in the new york metropolitan area. Neuroepidemiology 2016;46:51-6.
41. Ozel L, Demir R, Ozdemir G, et al. Investigation of the prevalence of essential tremor in individuals aged 18-60 in Erzurum. Acta Neurol Belg 2013;113:127-31.
42. Sur H, IlhanS, Erdogan H, Ozturk E, Tasdemir M, Boru UT. Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. Parkinsonism Relat Disord 2009;15:101-4.
43. DoguO, SevimS, Camdeviren H, et al. Prevalence of essential tremor: door-to-door neurologic exams in Mersin Province, Turkey. Neurology 2003;61:1804-6.
44. Kapinos KA, Louis ED. Annual healthcare costs among Medicare Beneficiaries with essential tremor. Parkinsonism Relat Disord 2022;104:26-9.
45. Shill HA, Adler CH, Beach TG. Lewy bodies are incidental inessential tremor. Parkinsonism Relat Disord 2016;26:81.
46. Benito-Leon J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 2003;18:389-94.
47. Seijo-Martinez M, Del Rio MC, Alvarez JR, et al. Prevalence of essential tremor on Arosa Island, Spain: a community-based, door-to-door survey. Tremor Other Hyperkinet Mov 2013;26:81.
48. Bergareche A, De La Puente E, Lopez De Munain A, et al. Prevalence of essential tremor: a door-to-door survey in bidasoa, spain. Neuroepidemiology 2001;20:125-8.
49. Louis ED, Marder K, Cote L, et al. Differences in the prevalence of essential tremor among elderly African Americans, whites, and Hispanics in northern Manhattan, NY. Arch Neurol 1995;52:1201-5.
50. Haerer AF, Anderson DW, Schoenberg BS. Prevalence of essential tremor. Results from the copiah county study. Arch Neurol 1982;39:750-1.
51. Louis ED, Thawani SP, Andrews HF. Prevalence of essential tremor in a multiethnic, community-based study in northern Manhattan, New York, N.Y. Neuroepidemiology 2009;32:208-14.
53. Tan LC, Venketasubramanian N, Ramasamy V, Gao W, Saw SM. Prevalence of essential tremor in Singapore: a study on three races in an Asian country. Parkinsonism Relat Disord 2005;11:233-9.
54. Glik A, Masarwa M, Abuful A, et al. Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages. Mov Disord 2009;24:119-22.
55. Inzelberg R, Mazarib A, Masarwa M, Abuful A, Strugatsky R, Friedland RF. Essential tremor prevalence is low in Arabic villages in Israel: door-to-door neurological examinations. J Neurol 2006;253:1557-60.
56. Deuschl G, Wenzelburger R, Loffler K, Raethjen J, Stolze H. Essential tremor and cerebellar dysfunction clinical and kinematic analysis of intention tremor. Brain 2000;123:1568-80.
57. Jenkins IH, Bain PG, Colebatch JG, et al. A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections. Ann Neurol 1993;34:82-90.
58. Boecker H, Wills AJ, Ceballos-Baumann A, et al. The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol 1996;39:650-8.
59. Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. Red nuclear and cerebellar but no olivary activation associated with essential tremor: a positron emission tomographic study. Ann Neurol 1994;36:636-42.
60. Wills AJ, Jenkins IH, Thompson PD, Findley LJ, Brooks DJ. A positron emission tomography study of cerebral activation associated with essential and writing tremor. Arch Neurol 1995;52:299-305.
61. Shill HA, De La Vega FJ, Samanta J, Stacy M. Motor learning in essential tremor. Mov Disord 2009;24:926-8.
62. Kronenbuerger M, Gerwig M, Brol B, Block F, Timmann D. Eyeblink conditioning is impaired in subjects with essential tremor. Brain 2007;130:1538-51.
63. Klebe S, Stolze H, Grensing K, Volkmann J, Wenzelburger R, Deuschl G. Influence of alcohol on gait in patients with essential tremor. Neurology 2005;65:96-101.
64. Rajput AH, Rozdilsky B, Ang L, Rajput A. Clinicopathologic observations in essential tremor: report of six cases. Neurology 1991;41:1422-4.
65. Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, Pahwa R. Neuropathologic findings in essential tremor. Neurology 2006;66:1756-9.
66. Louis ED, Yi H, Erickson-Davis C, Vonsattel JP, Faust PL. Structural study of Purkinje cell axonal torpedoes in essential tremor. Neurosci Lett 2009;450:287-91.
67. Shill HA, Adler CH, Sabbagh MN, et al. Pathologic findings in prospectively ascertained essential tremor subjects. Neurology 2008;70:1452-5.
68. Louis ED, Faust PL, Vonsattel JP, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 2007;130:3297-307.
69. Louis ED, Faust PL, Vonsattel JP, et al. Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains. Mov Disord 2009;24:1600-5.
70. Axelrad JE, Louis ED, Honig LS, et al. Reduced Purkinje cell number in essential tremor: a postmortem study. Arch Neurol 2008;65:101-7.
71. Louis ED, Babij R, Lee M, Cortes E, Vonsattel JP. Quantification of cerebellar hemispheric purkinje cell linear density: 32 ET cases versus 16 controls. Mov Disord 2013;28:1854-9.
72. Rajput AH, Robinson CA, Rajput ML, Rajput A. Cerebellar Purkinje cell loss is not pathognomonic of essential tremor. Parkinsonism Relat Disord 2011;17:16-21.
73. Rajput AH, Robinson CA, Rajput ML, Robinson SL, Rajput A. Essential tremor is not dependent upon cerebellar Purkinje cell loss. Parkinsonism Relat Disord 2012;18:626-8.
74. Symanski C, Shill HA, Dugger B, et al. Essential tremor is not associated with cerebellar Purkinje cell loss. Mov Disord 2014;29:496-500.
76. Shill HA, Adler CH, Hentz JG. Reply: Purkinje cell loss inessential tremor. Mov Disord 2014;29:1330- 1.
77. Tremblay C, Serrano GE, Dunckley N, et al. Postmortem cerebellar volume is not reduced in essential tremor: a comparison with multiple system atrophy and controls. J Parkinsons Dis 2023;13:333-40.
78. Kuo SH, Erickson-Davis C, Gillman A, Faust PL, Vonsattel JP, Louis ED. Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry 2011;82:1038-40.
79. Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. "Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol 2010;69:262-71.
80. Lee D, Gan SR, Faust PL, Louis ED, Kuo SH. Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes. Parkinsonism Relat Disord 2018;51:24-9.
81. Louis ED, Babij R, Cortes E, Vonsattel JP, Faust PL. The inferior olivary nucleus: a postmortem study of essential tremor cases versus controls. Mov Disord 2013;28:779-86.
82. Babij R, Lee M, Cortes E, Vonsattel JP, Faust PL, Louis ED. Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. Brain 2013;136:3051-61.
83. Gasparini M, Bonifati V, Fabrizio E, et al. Frontal lobe dysfunction in essential tremor: a preliminary study. J Neurol 2001;248:399-402.
84. Lacritz LH, Dewey R, Jr. , Giller C, Cullum CM. Cognitive functioning in individuals with "benign" essential tremor. J Int Neuropsychol Soc 2002;8:125-9.
85. Lombardi WJ, Woolston DJ, Roberts JW, Gross RE. Cognitive deficits in patients with essential tremor. Neurology 2001;57:785-90.
86. Troster AI, Woods SP, Fields JA, et al. Neuropsychological deficits inessential tremor: an expression ofcerebello-thalamo-cortical pathophysiology? Eur J Neurol 2002;9:143-51.
87. Benito-Leon J, Louis ED, Bermejo-Pareja F. Neurological Disorders in Central Spain Study G. Population-based case-control study of cognitive function in essential tremor. Neurology 2006;66:69-74.
88. Louis ED, Benito-Leon J, Bermejo-Pareja F. Population-based study of baseline ethanol consumption and risk of incident essential tremor. J Neurol Neurosurg Psychiatry 2009;80:494-7.
89. Benito-Leon J, Louis ED, Sanchez-Ferro A, Bermejo-Pareja F. Rate of cognitive decline during the premotor phase of essential tremor: a prospective study. Neurology 2013;81:60-6.
90. Benito-Leon J, Louis ED, Bermejo-Pareja F. Neurological Disorders in Central Spain Study G. Elderly-onset essential tremor is associated with dementia. Neurology 2006;66:1500-5.
91. Bermejo-Pareja F, Louis ED, Benito-Leon J. Neurological Disorders in Central Spain Study G. Risk of incident dementia in essential tremor: a population-based study. Mov Disord 2007;22:1573-80.
92. Thawani SP, Schupf N, Louis ED. Essential tremor is associated with dementia: prospective population-based study in New York. Neurology 2009;73:621-5.
93. Shill HA, Hentz JG, Jacobson SA, et al. Essential tremor in the elderly and risk for dementia. J Neurodegener Dis 2014;2014:328765.
94. Fields JA, Troster AI, Woods SP, et al. Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor. J Neurol Neurosurg Psychiatry 2003;74:305-11.
95. Lucas JA, Rippeth JD, Uitti RJ, Shuster EA, Wharen RE. Neuropsychological functioning in a patient with essential tremor with and without bilateral VIM stimulation. Brain Cogn 2000;42:253-67.
96. Ondo WG, Jankovic J, Connor GS, et al. Topiramate in essential tremor: a double-blind, placebo-controlled trial. Neurology 2006;66:672-7.
97. Connor GS, Edwards K, Tarsy D. Topiramate in essential tremor: findings from double-blind, placebo-controlled, crossover trials. Clin Neuropharmacol 2008;31:97-103.
99. Adler CH, Shill HA, Beach TG. Essential tremor and Parkinson's disease: lack of a link. MovDisord 2011;26:372-7.
100. Thenganatt MA, Jankovic J. The relationship between essential tremor and Parkinson's disease. Parkinsonism Relat Disord 2016;22 Suppl 1:S162-5.
101. Koller WC, Busenbark K, Miner K. The relationship of essential tremor to other movement disorders: report on 678 patients. essential tremor study group. Ann Neurol 1994;35:717-23.
102. Lou JS, Jankovic J. Essential tremor: clinical correlates in 350 patients. Neurology 1991;41:234-8.
103. Geraghty JJ, Jankovic J, Zetusky WJ. Association between essential tremor and Parkinson's disease. Ann Neurol 1985;17:329-33.
104. Benito-Leon J, Louis ED, Bermejo-Pareja F, Neurological Disorders in Central Spain Study G. Risk of incident Parkinson's disease and parkinsonism inessential tremor: a population based study. J Neurol Neurosurg Psychiatry 2009;80:423-5.
105. Louis ED, Asabere N, Agnew A, et al. Rest tremor in advanced essential tremor: a post-mortem study of nine cases. J Neurol Neurosurg Psychiatry 2011;82:261-5.
106. Aslam S, Zhang N, Adler CH, et al. Clinicopathologic correlations of jaw tremor in a longitudinal aging study . Neurol Clin Pract 2022;12:e85-92.
107. Rajput A, Robinson CA, Rajput AH. Essential tremor course and disability: A clinicopathologic study of 20 cases. Neurology 2004;62:932-6.
108. Rajput AH, Rajput EF, Bocking SM, Auer RN, Rajput A. Parkinsonism in essential tremor cases: A clinicopathological study. Mov Disord 2019;34:1031-40.
109. Louis ED, Iglesias-Hernandez D, Hernandez NC, et al. Characterizing lewy pathology in 231 essential tremor brains from the essential tremor centralized Brain repository. J Neuropathol Exp Neurol 2022;81:796-806.
110. Shill HA, Adler CH, Tremblay C, Beach TG. Lack of significant Lewy pathology in 237 essential tremor brains. J Neuropathol Exp Neurol 2023;82:452-3.
