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From:  Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer's disease
Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer's disease

Figure 9. PARP-1 inhibitors (1) inhibit PARP-1-promoted phosphorylation of tau and (2) inhibit the PARP-1 facilitated PARylation of neural DNA to retain neural viability[57,203]. Created with BioRender.com. PARP-1: Poly (ADP-ribose) polymerase-1.

Ageing and Neurodegenerative Diseases
ISSN 2769-5301 (Online)
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