fig7

Figure 7. Therapeutic strategies to address structural dysfunction related to tau pathology. Gene regulators (CypD KO), antioxidants (MitoQ), and enzyme inhibitors (sephin1, salubrinal) regulate the VDAC1 hyperphosphorylation pathway, inhibit ROS generation, and inhibit the integrated stress response-driven hyperphosphorylation of tau^[53-56]. Created with BioRender.com. CReP: Constitutive repressor of eIF2α phosphorylation; GADD34: growth arrest and DNA damage-inducible protein 34; KO: knockout; ROS: reactive oxidative species; VDAC1: voltage-dependent anion channel protein 1.