fig6
Figure 6. (A - C) Nf-L and pNf-H levels were not elevated in two of the three phase I trial subjects, but pNf-H was elevated in subject three; Nf-L was not elevated and did not respond to Treg/IL-2 therapy in subject three. Arrows indicate Treg infusion dates. The red dotted lines demarcate Treg + IL-2 therapy or IL-2 only intervals. Red line = mean value of each analyte in HC. Black lines ± one standard deviation of each analyte level in HC. The means and standard deviations vary due to the differences in ELISA plates used. AALS = Appel ALS clinical scoring system.
