REFERENCES
1. Aging and health. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health [Last accessed on 25 Mar 2022].
2. Jia J, Wei C, Chen S, et al. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers Dement 2018;14:483-91.
3. Sampathkumar NK, Bravo JI, Chen Y, et al. Widespread sex dimorphism in aging and age-related diseases. Hum Genet 2020;139:333-56.
4. Bronikowski AM, Altmann J, Brockman DK, et al. Aging in the natural world: comparative data reveal similar mortality patterns across primates. Science 2011;331:1325-8.
5. Fan J, Yu C, Guo Y, et al. Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study. Lancet Public Health 2020;5:e650-60.
6. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr 2008;8:24.
7. Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE. Sex differences in frailty: a systematic review and meta-analysis. Exp Gerontol 2017;89:30-40.
8. Oksuzyan A, Petersen I, Stovring H, Bingley P, Vaupel JW, Christensen K. The male-female health-survival paradox: a survey and register study of the impact of sex-specific selection and information bias. Ann Epidemiol 2009;19:504-11.
9. Rajan KB, Weuve J, Barnes LL, McAninch EA, Wilson RS, Evans DA. Population estimate of people with clinical Alzheimer’s disease and mild cognitive impairment in the United States (2020-2060). Alzheimers Dement 2021;17:1966-75.
10. Moisan F, Kab S, Mohamed F, et al. Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis. J Neurol Neurosurg Psychiatry 2016;87:952-7.
11. Nebel RA, Aggarwal NT, Barnes LL, et al. Understanding the impact of sex and gender in Alzheimer’s disease: a call to action. Alzheimers Dement 2018;14:1171-83.
12. Voyer D, Voyer SD, Saint-Aubin J. Sex differences in visual-spatial working memory: a meta-analysis. Psychon Bull Rev 2017;24:307-34.
13. Voyer D, Postma A, Brake B, Imperato-McGinley J. Gender differences in object location memory: a meta-analysis. Psychon Bull Rev 2007;14:23-38.
14. Asperholm M, Högman N, Rafi J, Herlitz A. What did you do yesterday? Psychol Bull 2019;145:785-821.
15. Jansen P, Kaltner S. Object-based and egocentric mental rotation performance in older adults: the importance of gender differences and motor ability. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2014;21:296-316.
16. Munro CA, Winicki JM, Schretlen DJ, et al. Sex differences in cognition in healthy elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2012;19:759-68.
17. Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med 2013;29:737-52.
19. de Frias CM, Nilsson LG, Nilsson A. Sex differences in cognition are stable over a 10-year period in adulthood and old age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2006;13:574-87.
20. Ferreira L, Ferreira Santos-Galduróz R, Ferri CP, Fernandes Galduróz JC. Rate of cognitive decline in relation to sex after 60 years-of-age: a systematic review. Geriatr Gerontol Int 2014;14:23-31.
21. Finkel D, Reynolds CA, Berg S, Pedersen NL. Surprising lack of sex differences in normal cognitive aging in twins. Int J Aging Hum Dev 2006;62:335-57.
22. Casaletto KB, Elahi FM, Staffaroni AM, et al. Cognitive aging is not created equally: differentiating unique cognitive phenotypes in “normal” adults. Neurobiol Aging 2019;77:13-9.
23. McCarrey AC, An Y, Kitner-Triolo MH, Ferrucci L, Resnick SM. Sex differences in cognitive trajectories in clinically normal older adults. Psychol Aging 2016;31:166-75.
24. Proust-Lima C, Amieva H, Letenneur L, Orgogozo JM, Jacqmin-Gadda H, Dartigues JF. Gender and education impact on brain aging: a general cognitive factor approach. Psychol Aging 2008;23:608-20.
25. McDowell I, Xi G, Lindsay J, Tuokko H. Canadian study of health and aging: study description and patterns of early cognitive decline. Aging, Neuropsychology, and Cognition 2004;11:149-68.
26. Wilson RS, Hebert LE, Scherr PA, Barnes LL, Mendes de Leon CF, Evans DA. Educational attainment and cognitive decline in old age. Neurology 2009;72:460-5.
27. Yu F, Ryan LH, Schaie KW, Willis SL, Kolanowski A. Factors associated with cognition in adults: the Seattle Longitudinal Study. Res Nurs Health 2009;32:540-50.
28. Finkel D, Andel R, Gatz M, Pedersen NL. The role of occupational complexity in trajectories of cognitive aging before and after retirement. Psychol Aging 2009;24:563-73.
29. Noh HM, Han J, Kim YJ, Jung JH, Roh YK, Song HJ. Sex differences in the relationship between cognitive impairment and overweight or obesity in late life: a 3-year prospective study. Medicine (Baltimore) 2019;98:e14736.
30. Gerstorf D, Ram N, Hoppmann C, Willis SL, Schaie KW. Cohort differences in cognitive aging and terminal decline in the Seattle Longitudinal Study. Dev Psychol 2011;47:1026-41.
31. Karlsson P, Thorvaldsson V, Skoog I, Gudmundsson P, Johansson B. Birth cohort differences in fluid cognition in old age: comparisons of trends in levels and change trajectories over 30 years in three population-based samples. Psychol Aging 2015;30:83-94.
32. Chêne G, Beiser A, Au G, et al. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimers Dement 2015;11:310-20.
33. Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 2013;80:1778-83.
35. Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology 2007;29:125-32.
36. Wimo A, Ali GC, Guerchet M, Prince M, Prina M, Wu YT. World Alzheimer Report 2015 - The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends. Available from: https://www.alzint.org/resource/world-alzheimer-report-2015/ [Last accessed on 25 Mar 2022].
37. Prince M, Ali GC, Guerchet M, Prina AM, Albanese E, Wu YT. Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res Ther 2016;8:23.
38. Tom SE, Hubbard RA, Crane PK, et al. Characterization of dementia and Alzheimer’s disease in an older population: updated incidence and life expectancy with and without dementia. Am J Public Health 2015;105:408-13.
39. Zahodne LB, Schofield PW, Farrell MT, Stern Y, Manly JJ. Bilingualism does not alter cognitive decline or dementia risk among Spanish-speaking immigrants. Neuropsychology 2014;28:238-46.
40. Fitzpatrick AL, Kuller LH, Ives DG, et al. Incidence and prevalence of dementia in the Cardiovascular Health Study. J Am Geriatr Soc 2004;52:195-204.
41. Prince M, Acosta D, Ferri CP, et al. Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. Lancet 2012;380:50-8.
42. Ruitenberg A, Ott A, van Swieten JC, Hofman A, Breteler MM. Incidence of dementia: does gender make a difference? Neurobiol Aging 2001;22:575-80.
43. Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer’s and vascular types. Biomed Res Int 2014;2014:908915.
44. Chen R, Hu Z, Wei L, Ma Y, Liu Z, Copeland JR. Incident dementia in a defined older Chinese population. PLoS One 2011;6:e24817.
45. Yamada M, Mimori Y, Kasagi F, et al. Incidence of dementia, Alzheimer disease, and vascular dementia in a Japanese population: Radiation Effects Research Foundation adult health study. Neuroepidemiology 2008;30:152-60.
46. Holland D, Desikan RS, Dale AM, McEvoy LK. Alzheimer’s Disease Neuroimaging Initiative. Higher rates of decline for women and apolipoprotein E epsilon4 carriers. AJNR Am J Neuroradiol 2013;34:2287-93.
47. Tifratene K, Robert P, Metelkina A, Pradier C, Dartigues JF. Progression of mild cognitive impairment to dementia due to AD in clinical settings. Neurology 2015;85:331-8.
48. Lin FC, Chuang YS, Hsieh HM, et al. Early statin use and the progression of Alzheimer disease: a total population-based case-control study. Medicine (Baltimore) 2015;94:e2143.
49. Laws KR, Irvine K, Gale TM. Sex differences in cognitive impairment in Alzheimer’s disease. World J Psychiatry 2016;6:54-65.
50. Gamberger D, Lavrač N, Srivatsa S, Tanzi RE, Doraiswamy PM. Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease. Sci Rep 2017;7:6763.
51. Todd S, Barr S, Roberts M, Passmore AP. Survival in dementia and predictors of mortality: a review. Int J Geriatr Psychiatry 2013;28:1109-24.
52. Vann Jones SA, O’Brien JT. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med 2014;44:673-83.
53. Hogan DB, Fiest KM, Roberts JI, et al. The prevalence and incidence of dementia with Lewy bodies: a systematic review. Can J Neurol Sci 2016;43 Suppl 1:S83-95.
54. Nelson PT, Schmitt FA, Jicha GA, et al. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol 2010;257:1875-81.
55. Savica R, Grossardt BR, Bower JH, Boeve BF, Ahlskog JE, Rocca WA. Incidence of dementia with Lewy bodies and Parkinson disease dementia. JAMA Neurol 2013;70:1396-402.
56. Goodman RA, Lochner KA, Thambisetty M, Wingo TS, Posner SF, Ling SM. Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011-2013. Alzheimers Dement 2017;13:28-37.
58. Mercy L, Hodges JR, Dawson K, Barker RA, Brayne C. Incidence of early-onset dementias in Cambridgeshire, United Kingdom. Neurology 2008;71:1496-9.
59. Bernardi L, Frangipane F, Smirne N, et al. Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy. Neurobiol Aging 2012;33:2948.e1-2948.e10.
60. Ikeda M, Ishikawa T, Tanabe H. Epidemiology of frontotemporal lobar degeneration. Dement Geriatr Cogn Disord 2004;17:265-8.
61. Borroni B, Alberici A, Grassi M, et al. Is frontotemporal lobar degeneration a rare disorder? J Alzheimers Dis 2010;19:111-6.
62. Curtis AF, Masellis M, Hsiung GR, et al. Sex differences in the prevalence of genetic mutations in FTD and ALS: a meta-analysis. Neurology 2017;89:1633-42.
63. Pringsheim T, Jette N, Frolkis A, Steeves TD. The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 2014;29:1583-90.
64. Hirsch L, Jette N, Frolkis A, Steeves T, Pringsheim T. The incidence of Parkinson’s disease: a systematic review and meta-analysis. Neuroepidemiology 2016;46:292-300.
65. Abbas MM, Xu Z, Tan LCS. Epidemiology of Parkinson’s disease-East versus West. Mov Disord Clin Pract 2018;5:14-28.
66. GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18:459-80.
67. Taylor KS, Cook JA, Counsell CE. Heterogeneity in male to female risk for Parkinson’s disease. J Neurol Neurosurg Psychiatry 2007;78:905-6.
68. de Lau LM, Verbaan D, Marinus J, van Hilten JJ. Survival in Parkinson’s disease. Relation with motor and non-motor features. Parkinsonism Relat Disord 2014;20:613-6.
69. Pinter B, Diem-Zangerl A, Wenning GK, et al. Mortality in Parkinson’s disease: a 38-year follow-up study. Mov Disord 2015;30:266-9.
70. Ascherio A, Schwarzschild MA. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 2016;15:1257-72.
71. Reekes TH, Higginson CI, Ledbetter CR, Sathivadivel N, Zweig RM, Disbrow EA. Sex specific cognitive differences in Parkinson disease. NPJ Parkinsons Dis 2020;6:7.
72. Sullivan EV, Rosenbloom M, Serventi KL, Pfefferbaum A. Effects of age and sex on volumes of the thalamus, pons, and cortex. Neurobiol Aging 2004;25:185-92.
73. DeCarli C, Massaro J, Harvey D, et al. Measures of brain morphology and infarction in the framingham heart study: establishing what is normal. Neurobiol Aging 2005;26:491-510.
74. Ikram MA, Vrooman HA, Vernooij MW, et al. Brain tissue volumes in the general elderly population. The Rotterdam Scan Study. Neurobiol Aging 2008;29:882-90.
75. Salat DH, Tuch DS, Greve DN, et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging 2005;26:1215-27.
76. Lemaître H, Crivello F, Grassiot B, Alpérovitch A, Tzourio C, Mazoyer B. Age- and sex-related effects on the neuroanatomy of healthy elderly. Neuroimage 2005;26:900-11.
77. Jäncke L, Mérillat S, Liem F, Hänggi J. Brain size, sex, and the aging brain. Hum Brain Mapp 2015;36:150-69.
78. Li W, van Tol MJ, Li M, et al. Regional specificity of sex effects on subcortical volumes across the lifespan in healthy aging. Hum Brain Mapp 2014;35:238-47.
79. Nemeth VL, Must A, Horvath S, Király A, Kincses ZT, Vécsei L. Gender-specific degeneration of dementia-related subcortical structures throughout the lifespan. J Alzheimers Dis 2017;55:865-80.
80. Wang Y, Xu Q, Luo J, Hu M, Zuo C. Effects of age and sex on subcortical volumes. Front Aging Neurosci 2019;11:259.
81. Goto M, Abe O, Miyati T, et al. Accelerated hippocampal volume reduction in post-menopausal women: an additional study with Atlas-based method. Radiol Phys Technol 2011;4:185-8.
82. Takahashi R, Ishii K, Kakigi T, Yokoyama K. Gender and age differences in normal adult human brain: voxel-based morphometric study. Hum Brain Mapp 2011;32:1050-8.
83. Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 2001;14:685-700.
84. Luders E, Gaser C, Narr KL, Toga AW. Why sex matters: brain size independent differences in gray matter distributions between men and women. J Neurosci 2009;29:14265-70.
85. Cheng Y, Chou KH, Decety J, et al. Sex differences in the neuroanatomy of human mirror-neuron system: a voxel-based morphometric investigation. Neuroscience 2009;158:713-20.
86. Taki Y, Kinomura S, Sato K, Goto R, Kawashima R, Fukuda H. A longitudinal study of gray matter volume decline with age and modifying factors. Neurobiol Aging 2011;32:907-15.
87. Pfefferbaum A, Rohlfing T, Rosenbloom MJ, Chu W, Colrain IM, Sullivan EV. Variation in longitudinal trajectories of regional brain volumes of healthy men and women (ages 10 to 85 years) measured with atlas-based parcellation of MRI. Neuroimage 2013;65:176-93.
88. Jiang J, Sachdev P, Lipnicki DM, et al. A longitudinal study of brain atrophy over two years in community-dwelling older individuals. Neuroimage 2014;86:203-11.
89. Narvacan K, Treit S, Camicioli R, Martin W, Beaulieu C. Evolution of deep gray matter volume across the human lifespan. Hum Brain Mapp 2017;38:3771-90.
90. Vinke EJ, de Groot M, Venkatraghavan V, et al. Trajectories of imaging markers in brain aging: the Rotterdam Study. Neurobiol Aging 2018;71:32-40.
91. Ikram MA, Brusselle GGO, Murad SD, et al. The Rotterdam Study: 2018 update on objectives, design and main results. Eur J Epidemiol 2017;32:807-50.
92. Mattson MP, Arumugam TV. Hallmarks of brain aging: adaptive and Pathological modification by metabolic states. Cell Metab 2018;27:1176-99.
93. Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol 2012;13:566-78.
94. Demarest TG, McCarthy MM. Sex differences in mitochondrial (dys)function: Implications for neuroprotection. J Bioenerg Biomembr 2015;47:173-88.
95. Lloret A, Badía MC, Mora NJ, et al. Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer’s disease. Free Radic Biol Med 2008;44:2019-25.
96. Borrás C, Sastre J, García-sala D, Lloret A, Pallardó FV, Viña J. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic Biol Med 2003;34:546-52.
97. Guevara R, Santandreu FM, Valle A, Gianotti M, Oliver J, Roca P. Sex-dependent differences in aged rat brain mitochondrial function and oxidative stress. Free Radic Biol Med 2009;46:169-75.
98. Guevara R, Gianotti M, Oliver J, Roca P. Age and sex-related changes in rat brain mitochondrial oxidative status. Exp Gerontol 2011;46:923-8.
99. Gaignard P, Savouroux S, Liere P, et al. Effect of sex differences on brain mitochondrial function and its suppression by ovariectomy and in aged mice. Endocrinology 2015;156:2893-904.
100. Dkhil MA, Al-Shaebi EM, Lubbad MY, Al-Quraishy S. Impact of sex differences in brain response to infection with Plasmodium berghei. Parasitol Res 2016;115:415-22.
101. Khalifa AR, Abdel-Rahman EA, Mahmoud AM, et al. Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 2017;5:e13125.
102. Ali SS, Xiong C, Lucero J, Behrens MM, Dugan LL, Quick KL. Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell 2006;5:565-74.
103. Viña J, Borrás C. Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds. Antioxid Redox Signal 2010;13:269-78.
104. Mandal PK, Tripathi M, Sugunan S. Brain oxidative stress: detection and mapping of anti-oxidant marker ‘Glutathione’ in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy. Biochem Biophys Res Commun 2012;417:43-8.
105. Rekkas PV, Wilson AA, Lee VW, et al. Greater monoamine oxidase a binding in perimenopausal age as measured with carbon 11-labeled harmine positron emission tomography. JAMA Psychiatry 2014;71:873-9.
106. Bellanti F, Matteo M, Rollo T, et al. Sex hormones modulate circulating antioxidant enzymes: impact of estrogen therapy. Redox Biol 2013;1:340-6.
107. Candeias E, Duarte AI, Sebastião I, et al. Middle-aged diabetic females and males present distinct susceptibility to Alzheimer disease-like pathology. Mol Neurobiol 2017;54:6471-89.
108. Sobocanec S, Balog T, Kusić B, Sverko V, Sarić A, Marotti T. Differential response to lipid peroxidation in male and female mice with age: correlation of antioxidant enzymes matters. Biogerontology 2008;9:335-43.
109. Silva TLA, Braz GRF, Silva SCA, et al. Serotonin transporter inhibition during neonatal period induces sex-dependent effects on mitochondrial bioenergetics in the rat brainstem. Eur J Neurosci ;2018:1620-34.
110. Cole TB, Coburn J, Dao K, et al. Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain. Toxicology 2016;374:1-9.
111. Monte AS, Mello BSF, Borella VCM, et al. Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: study of sex differences and brain oxidative alterations. Behav Brain Res 2017;331:30-7.
112. Al-Gubory KH, Garrel C. Sex-specific divergence of antioxidant pathways in fetal brain, liver, and skeletal muscles. Free Radic Res 2016;50:366-73.
113. Uzun H, Kayali R, Cakatay U. The chance of gender dependency of oxidation of brain proteins in aged rats. Arch Gerontol Geriatr 2010;50:16-9.
114. Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid. Neurobiol Aging 2012;33:1507-21.
115. Grimm A, Mensah-Nyagan AG, Eckert A. Alzheimer, mitochondria and gender. Neurosci Biobehav Rev 2016;67:89-101.
116. Serrano-Regal MP, Bayón-Cordero L, Ordaz RP, et al. Expression and function of GABA receptors in myelinating cells. Front Cell Neurosci 2020;14:256.
117. Bernaus A, Blanco S, Sevilla A. Glia crosstalk in neuroinflammatory diseases. Front Cell Neurosci 2020;14:209.
118. Augusto-Oliveira M, Arrifano GP, Takeda PY, et al. Astroglia-specific contributions to the regulation of synapses, cognition and behaviour. Neurosci Biobehav Rev 2020;118:331-57.
119. Thion MS, Low D, Silvin A, et al. Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell 2018;172:500-516.e16.
120. Villa A, Gelosa P, Castiglioni L, et al. Sex-specific features of microglia from adult mice. Cell Rep 2018;23:3501-11.
121. Hanamsagar R, Alter MD, Block CS, Sullivan H, Bolton JL, Bilbo SD. Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. Glia 2017;65:1504-20.
122. Hayakawa N, Kato H, Araki T. Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector. Mech Ageing Dev 2007;128:311-6.
123. Mouton PR, Long JM, Lei D, et al. Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res 2002;956:30-5.
124. Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007;55:412-24.
125. Bonham LW, Sirkis DW, Yokoyama JS. The transcriptional landscape of microglial genes in aging and neurodegenerative disease. Front Immunol 2019;10:1170.
126. Mangold CA, Wronowski B, Du M, et al. Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging. J Neuroinflammation 2017;14:141.
127. Sala Frigerio C, Wolfs L, Fattorelli N, et al. The major risk factors for Alzheimer’s disease: age, sex, and genes modulate the microglia response to Aβ plaques. Cell Rep 2019;27:1293-1306.e6.
128. Kang SS, Ebbert MTW, Baker KE, et al. Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. J Exp Med 2018;215:2235-45.
129. Yanguas-Casás N, Crespo-Castrillo A, Arevalo MA, Garcia-Segura LM. Aging and sex: impact on microglia phagocytosis. Aging Cell 2020;19:e13182.
130. Del Moral M, Fröhlich N, Figarella K, Mojtahedi N, Garaschuk O. Effect of caloric restriction on the in vivo functional properties of aging microglia. Front Immunol 2020;11:750.
131. Chowen JA, Garcia-Segura LM. Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging. Mech Ageing Dev 2021;196:111473.
132. Cerghet M, Skoff RP, Bessert D, Zhang Z, Mullins C, Ghandour MS. Proliferation and death of oligodendrocytes and myelin proteins are differentially regulated in male and female rodents. J Neurosci 2006;26:1439-47.
133. Cerghet M, Skoff RP, Swamydas M, Bessert D. Sexual dimorphism in the white matter of rodents. J Neurol Sci 2009;286:76-80.
134. Young KM, Psachoulia K, Tripathi RB, et al. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013;77:873-85.
135. Yasuda K, Maki T, Kinoshita H, et al. Sex-specific differences in transcriptomic profiles and cellular characteristics of oligodendrocyte precursor cells. Stem Cell Res 2020;46:101866.
136. Li WW, Penderis J, Zhao C, Schumacher M, Franklin RJ. Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS. Exp Neurol 2006;202:250-4.
137. Anisimova AS, Alexandrov AI, Makarova NE, Gladyshev VN, Dmitriev SE. Protein synthesis and quality control in aging. Aging (Albany NY) 2018;10:4269-88.
138. Raihan O, Brishti A, Li Q, et al. SFRS11 loss leads to aging-associated cognitive decline by modulating LRP8 and ApoE. Cell Rep 2019;28:78-90.e6.
139. Pluvinage JV, Haney MS, Smith BAH, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature 2019;568:187-92.
140. Zullo JM, Drake D, Aron L, et al. Regulation of lifespan by neural excitation and REST. Nature 2019;574:359-64.
141. Yuan J, Chang SY, Yin SG, et al. Two conserved epigenetic regulators prevent healthy ageing. Nature 2020;579:118-22.
142. Tsuji T, Shimohama S. Protein degradation in Alzheimer’s disease and aging of the brain. Prog Mol Subcell Biol 2002;29:43-60.
143. Galluzzi L, Baehrecke EH, Ballabio A, et al. Molecular definitions of autophagy and related processes. EMBO J 2017;36:1811-36.
144. VerPlank JJS, Goldberg AL. Regulating protein breakdown through proteasome phosphorylation. Biochem J 2017;474:3355-71.
145. Ding Q, Keller JN. Proteasomes and proteasome inhibition in the central nervous system. Free Radic Biol Med 2001;31:574-84.
146. Zeng BY, Medhurst AD, Jackson M, Rose S, Jenner P. Proteasomal activity in brain differs between species and brain regions and changes with age. Mech Ageing Dev 2005;126:760-6.
147. Jenkins EC, Shah N, Gomez M, et al. Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations. EMBO Rep 2020;21:e48978.
148. Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY) 2017;9:1153-85.
149. Dulka BN, Trask S, Helmstetter FJ. Age-related memory impairment and sex-specific alterations in phosphorylation of the Rpt6 proteasome subunit and polyubiquitination in the basolateral amygdala and medial prefrontal cortex. Front Aging Neurosci 2021;13:656944.
151. Congdon EE. Sex differences in autophagy contribute to female vulnerability in Alzheimer’s disease. Front Neurosci 2018;12:372.