Article

Open Access  |  Editorial
Ageing Neur Dis 2021;1:1. 10.20517/and.2021.01 © The Author(s) 2021.

Inauguration of a unique journal Ageing and Neurodegenerative Diseases: a new beginning seeking cures for age-related neurodegenerative diseases

Views: 2881 |  Downloads: 828 |  Cited:  2

1Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan, China.

2Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, Liaoning, China.

Correspondence Address: Prof. Wei-Dong Le, Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial People’s Hospital, No. 32, West 2 Part, 1 Ring Road, Chengdu 610072, Sichuan, China. E-mail: wdle@sibs.ac.cn

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Introduction

As the Editor-in-Chief of the newly founded journal Ageing and Neurodegenerative Diseases (AND), I am honored to introduce this journal to you on behalf of the OAE Publishing Inc.

AND is a peer-reviewed and open access multidisciplinary journal publishing high-quality original articles, reviews, case reports, commentaries, letters to the editor, etc. The aims of this journal are to report innovative research advances in the cellular and molecular mechanisms underlying the ageing process and age-related neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, etc. We are also interested in publishing innovative research describing therapeutic interventions in this field. Through this journal, we aim to promote collaboration and interaction among basic scientists, clinicians, and industrial experts. Our ultimate goal is to find solutions for slowing the ageing process, which will hopefully ameliorate and/or delay the onset of neurodegenerative diseases.

Ageing population is a big challenge to our society

According to the World Health Organization, nearly two billion people across the world are expected to be over 60 years old by 2050, which is twice the ageing population in 2000. With the increasing life expectancy, the global ageing population has expanded rapidly in recent decades. In order to adapt to the increasing ageing population, many countries have raised the retirement age, reduced pension benefits, and have started spending more on elderly care. Health is the biggest issue that comes with ageing. Because of the increase in the ageing population, the prevalence of age-related chronic diseases has increased dramatically. These chronic diseases, including cardiovascular disease, diabetes, cancers, and neurodegenerative diseases, have become an urgent challenge, as there are currently no effective therapies for many of them. The governments in many countries have spent a significant resource to conduct research seeking solutions to delay the ageing process and reduce the incidence of most common age-related diseases.

Uncovering the mechanisms underlying the ageing process is an urgent task

Ageing is a natural process defined as the progressive deterioration of biological functions after the organism has attained its maximal reproductive competence. During the ageing process, our body suffers from a serious of metabolism abnormality and cell damage, which leads to the phenotypes of ageing, along with age-related diseases. Among the age-related diseases, neurodegenerative diseases have received a lot of attention due to their irreversibility, lack of effective treatments, and their associated social and economic burdens. Brain ageing has been considered to predispose to neurodegenerative disorders. At a cellular level, brain ageing is characterized by increased inflammation, oxidative stress, increased genomic instability, telomere attrition, epigenetic alterations, metabolism impairment, protein homeostasis disturbance, mitochondrial dysfunction, cellular senescence, nutrient sensing deregulation, stem cell exhaustion and intercellular communication blockage [Figure 1]. However, despite intensive research, the exact molecular mechanisms underlying the ageing process, particularly the molecular pathways and networks accounting for the switch from physiological brain ageing to neurodegeneration, remain to be fully elucidated. A better understanding of the genetic and non-genetic factors regulating the ageing process will greatly benefit the discovery of anti-ageing remedies and novel therapies for neurodegenerative diseases.

Inauguration of a unique journal <i>Ageing and Neurodegenerative Diseases</i>: a new beginning seeking cures for age-related neurodegenerative diseases

Figure 1. The hallmarks of ageing, the biomarkers and intervention for neurodegenerative diseases. The scheme enumerates the hallmarks of ageing, and displays the proposed pathogenesis, biomarkers and interventions for several neurodegenerative diseases.

Age-related neurodegenerative diseases are a leading concern in neuroscience and neurology research

The ageing society today is confronted with an epidemic of chronic diseases, among which neurodegenerative diseases present an ever-growing medical and social burden. Ageing is a major risk factor for neurodegeneration, and that the prevalence of age-related neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, etc. has dramatically increased in recent decades. Unfortunately, no treatments have been shown to slow the neurodegeneration in patients with these diseases. Thus, to develop successful interventions, it is extremely important to investigate the basic mechanisms of ageing and their role in the onset and progression of neurodegenerative diseases, the results of which will facilitate the discovery of potential targets for novel therapies for neurodegenerative diseases. In addition, early clinical intervention is crucial for the management of patients with neurodegenerative diseases. However, the lack of specific biomarkers for their accurate diagnosis hinders early clinical diagnosis and intervention of these devastating diseases. Furthermore, the discovery and development of novel effective therapies for neurodegenerative diseases largely depends on reliable biomarkers of mechanism and target engagement to accelerate therapeutic development [Figure 1]. Thus, we plan to launch this new journal, which is aimed to stimulate and communicate the innovative research on age-related neurodegenerative diseases, and enhance the collaboration and interaction among basic scientists, clinicians and industrial experts. We welcome you to submit your papers to this unique and promising journal of AND.

Declarations

Authors’ contributions

Preparing the manuscript draft: Le WD

Availability of data and material

Not applicable.

Financial support and sponsorship

None.

Conflicts of interest

The author declared that there are no conflicts of interest.

Ethical approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Copyright

© The Author(s) 2021.

Cite This Article

OAE Style

Le WD. Inauguration of a unique journal Ageing and Neurodegenerative Diseases: a new beginning seeking cures for age-related neurodegenerative diseases. Ageing Neur Dis 2021;1:1. http://dx.doi.org/10.20517/and.2021.01

AMA Style

Le WD. Inauguration of a unique journal Ageing and Neurodegenerative Diseases: a new beginning seeking cures for age-related neurodegenerative diseases. Ageing and Neurodegenerative Diseases. 2021; 1(1): 1. http://dx.doi.org/10.20517/and.2021.01

Chicago/Turabian Style

Le, Wei-Dong. 2021. "Inauguration of a unique journal Ageing and Neurodegenerative Diseases: a new beginning seeking cures for age-related neurodegenerative diseases" Ageing and Neurodegenerative Diseases. 1, no.1: 1. http://dx.doi.org/10.20517/and.2021.01

ACS Style

Le, W.D. Inauguration of a unique journal Ageing and Neurodegenerative Diseases: a new beginning seeking cures for age-related neurodegenerative diseases. Ageing. Neur. Dis. 2021, 1, 1. http://dx.doi.org/10.20517/and.2021.01

Views
2881
Downloads
828
Citations
2
Comments
0
10

Related

Open Access Review
Unraveling the tau puzzle: a review of mechanistic targets and therapeutic interventions to prevent tau pathology in Alzheimer’s disease
Available online: 26 Oct 2023
Open Access Review
Essential tremor and ageing
Available online: 26 Oct 2023
Open Access Letter to Editor
Potential effects of Chinese herbs on iron metabolism for the treatment of stroke
Available online: 19 Sep 2023
Open Access Review
The versatile applications of human pluripotent stem cell-derived microglia and microglia-containing brain organoids
Available online: 6 Sep 2023
Open Access Review
Development of small molecules for disrupting pathological amyloid aggregation in neurodegenerative diseases
Available online: 28 Aug 2023
Open Access Editorial
Animal models for research on neurodegenerative diseases
Available online: 27 Aug 2023
Open Access Review
Cannabinoid modulations of pain- and stress-related circuits
Available online: 24 Aug 2023
Open Access Original Article
Immunological, oxidative, and structural factors and their responses to regulatory t lymphocyte therapy in amyotrophic lateral sclerosis
Available online: 22 Aug 2023
Open Access Review
Research progress on the role of PGC1α in mitochondrial dysfunction associated with Alzheimer’s disease
Available online: 30 Jul 2023
Open Access Review
Amyloid-β-targeted therapies for Alzheimer’s disease: currently and in the future
Available online: 30 Jul 2023

Comments

Comments must be written in English. Spam, offensive content, impersonation, and private information will not be permitted. If any comment is reported and identified as inappropriate content by OAE staff, the comment will be removed without notice. If you have any queries or need any help, please contact us at support@oaepublish.com.

0
Cite This Article 28 clicks
Commentary 0 comments
Like This Article 10 likes
Share This Article
Scan the QR code for reading!
See Updates
Contents
Figures
Related
Hot Topics
Ageing | Neurodegenerative Diseases | Neurodegeneration | AD |
Ageing and Neurodegenerative Diseases
ISSN 2769-5301 (Online)

Portico

All published articles will be preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles will be preserved here permanently:

https://www.portico.org/publishers/oae/