REFERENCES
1. Chocron ES, Munkácsy E, Pickering AM. Cause or casualty: the role of mitochondrial DNA in aging and age-associated disease. Biochim Biophys Acta Mol Basis Dis. 2019;1865:285-97.
2. Iacobazzi V, Castegna A, Infantino V, Andria G. Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Mol Genet Metab. 2013;110:25-34.
3. Jones PA, Liang G. Rethinking how DNA methylation patterns are maintained. Nat Rev Genet. 2009;10:805-11.
4. Shock LS, Thakkar PV, Peterson EJ, Moran RG, Taylor SM. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci USA. 2011;108:3630-5.
5. Becker LB, Vanden Hoek TL, Shao Z, Li C, Schumacker PT. Generation of superoxide in cardiomyocytes during ischemia before reperfusion. Am J Physiol Heart Circ Physiol. 1999;277:H2240-6.
6. Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev. 2014;94:909-50.
7. Wang P, Shen C, Diao L, et al. Aberrant hypermethylation of aldehyde dehydrogenase 2 promoter upstream sequence in rats with experimental myocardial infarction. BioMed Res Int. 2015;2015:1-13.
8. Liu H, Jiang B, Hua R, et al. ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling. Cardiovasc Diabetol. 2024;23:380.
9. Zhang F, Zhang L, Hu G, et al. Rectifying METTL4-mediated N6-methyladenine excess in mitochondrial DNA alleviates heart failure. Circulation. 2024;150:1441-58.
10. Yang K, Gao R, Chen H, et al. Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition. Eur Heart J. 2024;45:1662-80.
11. Liu X, Sun A. Aldehyde dehydrogenase-2 roles in ischemic cardiovascular disease. Curr Drug Targets. 2017;18:1817-23.
12. Sun A, Zou Y, Wang P, et al. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice. J Am Heart Assoc. 2014;3:e000779.
13. Nicholls TJ, Gustafsson CM. Separating and segregating the human mitochondrial genome. Trends Biochem Sci. 2018;43:869-81.
14. Boovarahan SR, Kurian GA. Investigating the role of DNMT1 gene expression on myocardial ischemia reperfusion injury in rat and associated changes in mitochondria. Biochim Biophys Acta. 2022;1863:148566.
15. Boovarahan SR, Kurian GA. Ischemic preconditioning modulates the DNA methylation process of the rat heart to provide tolerance to withstand ischemia reperfusion injury and its associated mitochondrial dysfunction. 3 Biotech. 2024;14:121.
16. Chen C, Budas GR, Churchill EN, Disatnik M, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science. 2008;321:1493-5.





