REFERENCES

1. Kataoka S, Ejima K, Yazaki K, et al. Impact of atrial fibrillation ablation on long-term outcomes in patients with tachycardia-bradycardia syndrome. J Arrhythm. 2022;38:598-607.

2. Duan S, Du J. Sinus node dysfunction and atrial fibrillation—relationships, clinical phenotypes, new mechanisms, and treatment approaches. Ageing Res Rev. 2023;86:101890.

3. Hwang TH, Yu HT, Kim T, et al. Permanent pacemaker implantations after catheter ablation in patients with atrial fibrillation associated with underlying sinus node dysfunction. Korean Circ J. 2020;50:346.

4. Lamas GA, Lee KL, Sweeney MO, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med. 2002;346:1854-62.

5. John RM, Kumar S. Sinus node and atrial arrhythmias. Circulation. 2016;133:1892-900.

6. Sairaku A, Nakano Y, Oda N, et al. Prediction of sinus node dysfunction in patients with long-standing persistent atrial fibrillation using the atrial fibrillatory cycle length. J Electrocardiol. 2012;45:141-7.

7. Sunaga A, Masuda M, Kanda T, et al. A low fibrillatory wave amplitude predicts sinus node dysfunction after catheter ablation in patients with persistent atrial fibrillation. J Interv Card Electrophysiol. 2015;43:253-61.

8. Motoda C, Nakano Y, Oda N, et al. Sleep-disordered breathing predicts sinus node dysfunction in persistent atrial fibrillation patients undergoing pulmonary vein isolation. J Cardiol. 2012;60:321-6.

9. Bakhshi H, Michelhaugh SA, Bruce SA, et al. Association between proteomic biomarkers and myocardial fibrosis measured by MRI: the multi-ethnic study of atherosclerosis. eBioMedicine. 2023;90:104490.

10. Park H, Norby FL, Kim D, et al. Proteomic signatures for risk prediction of atrial fibrillation. Circulation. 2025;152:217-29.

11. Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.

12. Zhelyakov EG, Ardashev AV. Endocardial electrophysiological study in clinical practice in patients with bradysystole and conduction rhythm disorders: a review. Cardiac Arrhythmias. 2022;2:19-30.

13. Pietrucha AZ, Wnuk M, WojewÓdka-Żak E, et al. Evaluation of sinus and atrioventricular nodes function in patients with vasovagal syncope. Pacing Clin Electrophysiol. 2009;32:S158-62.

14. Mezzano V, Liang Y, Wright AT, et al. Desmosomal junctions are necessary for adult sinus node function. Cardiovasc Res. 2016;111:274-86.

15. Yaniv Y, Juhaszova M, Lyashkov AE, Spurgeon HA, Sollott SJ, Lakatta EG. Ca²⁺-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand. J Mol Cell Cardiol. 2011;51:740-8.

16. Ren L, Gopireddy RR, Perkins G, et al. Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure. Proc Natl Acad Sci USA. 2022;119:e2206708119.

17. Ren X, Shan W, Wei L, Gong C, Pei D. ACP5: its structure, distribution, regulation and novel functions. Anti Cancer Agents Med Chem. 2018;18:1082-90.

18. Yang S, Pei L, Huang Z, et al. Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction. Mol Med. 2024;30:89.

19. Morisawa T, Nakagomi A, Kohashi K, Kusama Y, Shimizu W. Serum tartrate-resistant acid phosphatase-5b levels are associated with the severity and extent of coronary atherosclerosis in patients with coronary artery disease. J Atheroscler Thromb. 2017;24:1058-68.