REFERENCES
1. Karalapillai D, Weinberg L, Peyton P, et al. Effect of intraoperative low tidal volume vs conventional tidal volume on postoperative pulmonary complications in patients undergoing major surgery: a randomized clinical trial. JAMA 2020;324:848-58.
2. Lee B, Kim KS, Shim JK, Kim HB, Jun B, Kwak YL. Increased carotid intima-media thickness was not associated with cognitive dysfunction after off-pump coronary surgery in older adult patients without carotid stenosis. Semin Thorac Cardiovasc Surg 2022;34:112-21.
3. Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 2008;108:18-30.
4. Silverstein JH, Timberger M, Reich DL, Uysal S. Central nervous system dysfunction after noncardiac surgery and anesthesia in the elderly. Anesthesiology 2007;106:622-8.
5. Granger KT, Barnett JH. Postoperative cognitive dysfunction: an acute approach for the development of novel treatments for neuroinflammation. Drug Discov Today 2021;26:1111-4.
6. Shi Y, Qu S. Cognitive ability and self-control’s influence on high school students’ comprehensive academic performance. Front Psychol 2021;12:783673.
7. Shi Y, Qu S. The effect of cognitive ability on academic achievement: the mediating role of self-discipline and the moderating role of planning. Front Psychol 2022;13:1014655.
8. Liang X, Zhang R. Effects of minocycline on cognitive impairment, hippocampal inflammatory response, and hippocampal alzheimer’s related proteins in aged rats after propofol anesthesia. Dis Markers 2022;2022:4709019.
9. Hough D, Bellingham M, Haraldsen IRH, et al. Spatial memory is impaired by peripubertal GnRH agonist treatment and testosterone replacement in sheep. Psychoneuroendocrinology 2017;75:173-82.
10. Hovens IB, Schoemaker RG, van der Zee EA, Absalom AR, Heineman E, van Leeuwen BL. Postoperative cognitive dysfunction: involvement of neuroinflammation and neuronal functioning. Brain Behav Immun 2014;38:202-10.
13. Silbert B, Evered L, Scott DA. Cognitive decline in the elderly: is anaesthesia implicated? Best Pract Res Clin Anaesthesiol 2011;25:379-93.
14. Rothwell NJ, Hopkins SJ. Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci 1995;18:130-6.
15. Beloosesky Y, Hendel D, Weiss A, et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci 2007;62:420-6.
16. Buvanendran A, Kroin JS, Berger RA, et al. Upregulation of prostaglandin E2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology 2006;104:403-10.
17. Umholtz M, Nader ND. Anesthetic immunomodulation of the neuroinflammation in postoperative cognitive dysfunction. Immunol Invest 2017;46:805-15.
18. Pribiag H, Stellwagen D. TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABAA receptors. J Neurosci 2013;33:15879-93.
20. Hou Y, Lu J, Xie J, et al. Effects of electroacupuncture on perioperative anxiety and stress response in patients undergoing surgery for gastric or colorectal cancer: study protocol for a randomized controlled trial. Front Psychiatry 2023;14:1095650.
21. Hovens IB, van Leeuwen BL, Mariani MA, Kraneveld AD, Schoemaker RG. Postoperative cognitive dysfunction and neuroinflammation; cardiac surgery and abdominal surgery are not the same. Brain Behav Immun 2016;54:178-93.
22. Subramaniyan S, Terrando N. Neuroinflammation and perioperative neurocognitive disorders. Anesth Analg 2019;128:781-8.
23. Eckenhoff RG, Maze M, Xie Z, et al. Perioperative neurocognitive disorder: state of the preclinical science. Anesthesiology 2020;132:55-68.
24. Liu Y, Fu H, Wang T. Neuroinflammation in perioperative neurocognitive disorders: from bench to the bedside. CNS Neurosci Ther 2022;28:484-96.
25. Evered L, Silbert B, Knopman DS, et al. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Anesthesiology 2018;129:872-9.
26. Anastasian ZH, Gaudet JG. 1 - effects of anesthetics, operative pharmacotherapy, and recovery from anesthesia. In: Kumar M, Levine J, Schuster J, Kofke WA, editors. Neurocritical care management of the neurosurgical patient. London: Elsevier; 2018. pp. 3-14.
27. Radtke FM, Franck M, Hagemann L, et al. Risk factors for inadequate emergence after anesthesia: emergence delirium and hypoactive emergence. Minerva Anestesiol 2010;76:394-403.
28. Yu D, Chai W, Sun X, Yao L. Emergence agitation in adults: risk factors in 2,000 patients. Can J Anaesth 2010;57:843-8.
29. Needham MJ, Webb CE, Bryden DC. Postoperative cognitive dysfunction and dementia: what we need to know and do. Br J Anaesth 2017;119:i115-25.
30. Capková J. Perioperačné neurologické komplikácie. In: Novinky V anestéziológii, algeziológii a intenzívnej medicíne. Pavol Šidelský: Akcent print; 2019. pp. 59-65 (in Slovak).
31. Lin X, Chen Y, Zhang P, Chen G, Zhou Y, Yu X. The potential mechanism of postoperative cognitive dysfunction in older people. Exp Gerontol 2020;130:110791.
32. Wang L, Lang Z, Gao H, Liu Y, Dong H, Sun X. The Relationship between the Incidence of postoperative cognitive dysfunction and intraoperative regional cerebral oxygen saturation after cardiovascular surgery: a systematic review and meta-analysis of randomized controlled trials. Rev Cardiovasc Med 2022;23:388.
33. Holmgaard F, Vedel AG, Rasmussen LS, Paulson OB, Nilsson JC, Ravn HB. The association between postoperative cognitive dysfunction and cerebral oximetry during cardiac surgery: a secondary analysis of a randomised trial. Br J Anaesth 2019;123:196-205.
34. Vedel AG, Holmgaard F, Rasmussen LS, et al. High-target versus low-target blood pressure management during cardiopulmonary bypass to prevent cerebral injury in cardiac surgery patients: a randomized controlled trial. Circulation 2018;137:1770-80.
35. Peng W, Lu W, Jiang X, et al. Current progress on neuroinflammation-mediated postoperative cognitive dysfunction: an update. Curr Mol Med 2023;23:1077-86.
37. Feinkohl I, Winterer G, Spies CD, Pischon T. Cognitive reserve and the risk of postoperative cognitive dysfunction. Dtsch Arztebl Int 2017;114:110-7.
38. Paredes S, Cortínez L, Contreras V, Silbert B. Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: a qualitative systematic review. Acta Anaesthesiol Scand 2016;60:1043-58.
39. Silbert B, Evered L, Scott DA, et al. Preexisting cognitive impairment is associated with postoperative cognitive dysfunction after hip joint replacement surgery. Anesthesiology 2015;122:1224-34.
40. van Zuylen ML, Gribnau A, Admiraal M, et al. The role of intraoperative hypotension on the development of postoperative cognitive dysfunction: a systematic review. J Clin Anesth 2021;72:110310.
41. Boone MD, Sites B, von Recklinghausen FM, Mueller A, Taenzer AH, Shaefi S. Economic burden of postoperative neurocognitive disorders among US medicare patients. JAMA Netw Open 2020;3:e208931.
42. Yang X, Huang X, Li M, Jiang Y, Zhang H. Identification of individuals at risk for postoperative cognitive dysfunction (POCD). Ther Adv Neurol Disord 2022;15:17562864221114356.
43. Berger M, Schenning KJ, Brown CH 4th, et al. Best practices for postoperative brain health: recommendations from the fifth international perioperative neurotoxicity working group. Anesth Analg 2018;127:1406-13.
44. Crocker E, Beggs T, Hassan A, et al. Long-term effects of postoperative delirium in patients undergoing cardiac operation: a systematic review. Ann Thorac Surg 2016;102:1391-9.
45. Gao S, Zhang S, Zhou H, et al. Role of mTOR-regulated autophagy in synaptic plasticity related proteins downregulation and the reference memory deficits induced by anesthesia/surgery in aged mice. Front Aging Neurosci 2021;13:628541.
46. Bhushan S, Li Y, Huang X, Cheng H, Gao K, Xiao Z. Progress of research in postoperative cognitive dysfunction in cardiac surgery patients: a review article. Int J Surg 2021;95:106163.
47. Trubnikova O, Tarasova I, Barbarash O. The influence of low and moderate carotid stenosis on neurophysiologic status of patients undergoing on-pump coronary artery bypass grafting. Front Neurol 2012;3:1.
48. Knipp SC, Weimar C, Schlamann M, et al. Early and long-term cognitive outcome after conventional cardiac valve surgery. Interact Cardiovasc Thorac Surg 2017;24:534-40.
49. Pérez-Belmonte LM, Florido-Santiago M, Millán-Gómez M, Barbancho MA, Gómez-Huelgas R, Lara JP. Research long-term cognitive impairment after off-pump versus on-pump cardiac surgery: involved risk factors. J Am Med Dir Assoc 2018;19:639-40.e1.
50. Rafnsson SB, Deary IJ, Fowkes FG. Peripheral arterial disease and cognitive function. Vasc Med 2009;14:51-61.
51. la Torre J. The vascular hypothesis of alzheimer’s disease: a key to preclinical prediction of dementia using neuroimaging. J Alzheimers Dis 2018;63:35-52.
52. Anazodo UC, Shoemaker JK, Suskin N, Ssali T, Wang DJ, St Lawrence KS. Impaired cerebrovascular function in coronary artery disease patients and recovery following cardiac rehabilitation. Front Aging Neurosci 2015;7:224.
53. Bangen KJ, Werhane ML, Weigand AJ, et al. Reduced regional cerebral blood flow relates to poorer cognition in older adults with type 2 diabetes. Front Aging Neurosci 2018;10:270.
54. Bunch TJ, Galenko O, Graves KG, Jacobs V, May HT. Atrial fibrillation and dementia: exploring the association, defining risks and improving outcomes. Arrhythm Electrophysiol Rev 2019;8:8-12.
55. Tarasova I, Trubnikova O, Kupriyanova D, et al. Effect of carotid stenosis severity on patterns of brain activity in patients after cardiac surgery. Appl Sci 2023;13:20.
56. Tarasova IV, Trubnikova OA, Barbarash OL. EEG and clinical factors associated with mild cognitive impairment in coronary artery disease patients. Dement Geriatr Cogn Disord 2018;46:275-84.
57. Georgiadis D, Sievert M, Cencetti S, et al. Cerebrovascular reactivity is impaired in patients with cardiac failure. Eur Heart J 2000;21:407-13.
58. Greaves D, Psaltis PJ, Ross TJ, et al. Cognitive outcomes following coronary artery bypass grafting: a systematic review and meta-analysis of 91,829 patients. Int J Cardiol 2019;289:43-9.
59. Paraskevas KI, Faggioli G, Ancetti S, Naylor AR. Editor’s choice - asymptomatic carotid stenosis and cognitive impairment: a systematic review. Eur J Vasc Endovasc Surg 2021;61:888-99.
60. Lal BK, Dux MC, Sikdar S, et al. Asymptomatic carotid stenosis is associated with cognitive impairment. J Vasc Surg 2017;66:1083-92.
61. Romero JR, Beiser A, Seshadri S, et al. Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke 2009;40:1590-6.
62. Fisher M, Paganini-Hill A, Martin A, et al. Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke 2005;36:253-7.
63. Glumac S, Kardum G, Karanovic N. Postoperative cognitive decline after cardiac surgery: a narrative review of current knowledge in 2019. Med Sci Monit 2019;25:3262-70.
64. Kalkman C. Can we influence postoperative cognitive dysfunction? Acta Anaesthesiol Belg 2007;58:227-229.
65. Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 2000;20:131-47.
66. Terrando N, Eriksson LI, Ryu JK, et al. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol 2011;70:986-95.
67. Reinsfelt B, Westerlind A, Blennow K, Zetterberg H, Ricksten SE. Open-heart surgery increases cerebrospinal fluid levels of Alzheimer-associated amyloid β. Acta Anaesthesiol Scand 2013;57:82-8.
68. Baufreton C, Allain P, Chevailler A, et al. Brain injury and neuropsychological outcome after coronary artery surgery are affected by complement activation. Ann Thorac Surg 2005;79:1597-605.
69. Peters van Ton AM, Duindam HB, van Tuijl J, et al. Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol. BMJ Open 2021;11:e044062.
70. Zhuang Y, Xu J, Zheng K, Zhang H. Research progress of postoperative cognitive dysfunction in cardiac surgery under cardiopulmonary bypass. Ibrain 2023; doi: 10.1002/ibra.12123.
71. D’mello C, Swain MG. Immune-to-brain communication pathways in inflammation-associated sickness and depression. In: Dantzer R, Capuron L, editors. Inflammation-Associated depression: evidence, mechanisms and implications. Cham: Springer International Publishing; 2017. pp. 73-94.
72. Varatharaj A, Galea I. The blood-brain barrier in systemic inflammation. Brain Behav Immun 2017;60:1-12.
73. Kolominsky-Rabas PL, Weber M, Gefeller O, Neundoerfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to TOAST criteria: incidence, recurrence, and long-term survival in ischemic stroke subtypes: a population-based study. Stroke 2001;32:2735-40.
74. Aboyans V, Ricco JB, Bartelink MEL, et al. 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the european society for vascular surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)the task force for the diagnosis and treatment of peripheral arterial diseases of the european society of cardiology (ESC) and of the European society for vascular surgery (ESVS). Eur Heart J 2018;39:763-816.
75. Eliasziw M, Smith RF, Singh N, Holdsworth DW, Fox AJ, Barnett HJ. Further comments on the measurement of carotid stenosis from angiograms. North American symptomatic carotid endarterectomy trial (NASCET) group. Stroke 1994;25:2445-9.
76. Naylor AR, Schroeder TV, Sillesen H. Clinical and imaging features associated with an increased risk of late stroke in patients with asymptomatic carotid disease. Eur J Vasc Endovasc Surg 2014;48:633-40.
77. Gray VL, Goldberg AP, Rogers MW, et al. Asymptomatic carotid stenosis is associated with mobility and cognitive dysfunction and heightens falls in older adults. J Vasc Surg 2020;71:1930-7.
78. Lin CJ, Tu PC, Chern CM, et al. Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS One 2014;9:e85441.
79. Zavoreo I, Bašić Kes V, Lisak M, Maršić N, Ciliga D, Trošt Bobić T. Cognitive decline and cerebral vasoreactivity in asymptomatic patients with severe internal carotid artery stenosis. Acta Neurol Belg 2013;113:453-8.
80. Dempsey RJ, Vemuganti R, Varghese T, Hermann BP. A review of carotid atherosclerosis and vascular cognitive decline: a new understanding of the keys to symptomology. Neurosurgery 2010;67:484-93; discussion 493.
81. Foret T, Guillaumin M, Desmarets M, Costa P, Rinckenbach S, du Mont LS. Association between carotid revascularization for asymptomatic stenosis and cognitive functions. Vasa 2022;51:138-49.
82. Luo A, Yan J, Tang X, Zhao Y, Zhou B, Li S. Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation. Inflammopharmacology 2019;27:27-37.
83. Netto MB, de Oliveira Junior AN, Goldim M, et al. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats. Brain Behav Immun 2018;73:661-9.
84. Zhang S, Dong H, Zhang X, Li N, Sun J, Qian Y. Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption. Behav Brain Res 2016;298:158-66.
85. Leyane TS, Jere SW, Houreld NN. Oxidative stress in ageing and chronic degenerative pathologies: molecular mechanisms involved in counteracting oxidative stress and chronic inflammation. Int J Mol Sci 2022;23:7273.
86. Vona R, Pallotta L, Cappelletti M, Severi C, Matarrese P. The impact of oxidative stress in human pathology: focus on gastrointestinal disorders. Antioxidants 2021;10:201.
87. Pappa M, Theodosiadis N, Tsounis A, Sarafis P. Pathogenesis and treatment of post-operative cognitive dysfunction. Electron Physician 2017;9:3768-75.
88. Chen L, Dong R, Lu Y, et al. MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice. Brain Behav Immun 2019;78:188-201.
89. Jin Z, Hu J, Ma D. Postoperative delirium: perioperative assessment, risk reduction, and management. Br J Anaesth 2020;125:492-504.
90. Zhao RZ, Jiang S, Zhang L, Yu ZB. Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med 2019;44:3-15.
91. O’Bryan LJ, Atkins KJ, Lipszyc A, Scott DA, Silbert BS, Evered LA. Inflammatory biomarker levels after propofol or sevoflurane anesthesia: a meta-analysis. Anesth Analg 2022;134:69-81.
92. Flick RP, Katusic SK, Colligan RC, et al. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery. Pediatrics 2011;128:e1053-61.
93. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003;23:876-82.
94. Evered L, Scott DA, Silbert B, Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth Analg 2011;112:1179-85.
95. Shin TJ, Kim PJ, Choi B. How general anesthetics work: from the perspective of reorganized connections within the brain. Korean J Anesthesiol 2022;75:124-38.
96. Bonhomme V, Staquet C, Montupil J, et al. General anesthesia: a probe to explore consciousness. Front Syst Neurosci 2019;13:36.
97. Li R, Zhang Y, Zhu Q, Wu Y, Song W. The role of anesthesia in peri-operative neurocognitive disorders: molecular mechanisms and preventive strategies. Fundam Res 2023; doi: 10.1016/j.fmre.2023.02.007.
98. Viderman D, Nabidollayeva F, Aubakirova M, Yessimova D, Badenes R, Abdildin Y. Postoperative delirium and cognitive dysfunction after general and regional anesthesia: a systematic review and meta-analysis. J Clin Med 2023;12:3549.
99. Iamaroon A, Wongviriyawong T, Sura-Arunsumrit P, Wiwatnodom N, Rewuri N, Chaiwat O. Incidence of and risk factors for postoperative delirium in older adult patients undergoing noncardiac surgery: a prospective study. BMC Geriatr 2020;20:40.
100. Brodier EA, Cibelli M. Postoperative cognitive dysfunction in clinical practice. BJA Educ 2021;21:75-82.
101. Ritiu SA, Rogobete AF, Sandesc D, et al. The impact of general anesthesia on redox stability and epigenetic inflammation pathways: crosstalk on perioperative antioxidant therapy. Cells 2022;11:1880.
102. Tomsič K, Nemec Svete A. A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs. Front Vet Sci 2022;9:987536.
103. Fodale V, Santamaria LB, Schifilliti D, Mandal PK. Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s disease. Anaesthesia 2010;65:388-95.
104. Wang CM, Chen WC, Zhang Y, Lin S, He HF. Update on the mechanism and treatment of sevoflurane-induced postoperative cognitive dysfunction. Front Aging Neurosci 2021;13:702231.
105. Wu M, Zhao L, Wang Y, et al. Ketamine regulates the autophagy flux and polarization of microglia through the HMGB1-RAGE axis and exerts antidepressant effects in mice. J Neuropathol Exp Neurol 2022;81:931-42.
106. Yuan J, Fei Y. Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization. Open Med 2022;17:897-906.
107. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci 2011;34:601-28.
108. Czyż-Szypenbejl K, Mędrzycka-Dąbrowska W, Kwiecień-Jaguś K, Lewandowska K. The occurrence of postoperative cognitive dysfunction (POCD) - systematic review. Psychiatr Pol 2019;53:145-60.
109. Kapoor MC. Neurological dysfunction after cardiac surgery and cardiac intensive care admission: a narrative review part 1: the problem; nomenclature; delirium and postoperative neurocognitive disorder; and the role of cardiac surgery and anesthesia. Ann Card Anaesth 2020;23:383-90.
110. Chan MT, Cheng BC, Lee TM, Gin T. BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol 2013;25:33-42.
111. Li S, Zhou Y, Hu H, et al. SIRT3 enhances the protective role of propofol in postoperative cognitive dysfunction via activating autophagy mediated by AMPK/mTOR pathway. Front Biosci 2022;27:303.
112. Hua M, Min J. Postoperative cognitive dysfunction and the protective effects of enriched environment: a systematic review. Neurodegener Dis 2020;20:113-22.
113. Cooper JS, Phuyal P, Shah N. Oxygen toxicity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.
114. Zhang L, Wang X, Yu W, et al. CB2R activation regulates TFEB-mediated autophagy and affects lipid metabolism and inflammation of astrocytes in POCD. Front Immunol 2022;13:836494.
115. Liu Q, Sun YM, Huang H, et al. Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation. J Neuroinflammation 2021;18:41.
116. Alfaleh MA, Razeeth Shait Mohammed M, Hashem AM, Abujamel TS, Alhakamy NA, Imran Khan M. Extracellular matrix detached cancer cells resist oxidative stress by increasing histone demethylase KDM6 activity. Saudi J Biol Sci 2024;31:103871.
117. Talarowska M, Gałecki P, Maes M, et al. Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder. Neurosci Lett 2012;510:127-31.
119. Yang YS, He SL, Chen WC, et al. Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction. Front Cell Neurosci 2022;16:1024475.
120. Prieto-Bermejo R, Romo-González M, Pérez-Fernández A, Ijurko C, Hernández-Hernández Á. Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side. J Exp Clin Cancer Res 2018;37:125.
121. Zhang J, Wang X, Vikash V, et al. ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev 2016;2016:4350965.
122. Lee KH, Cha M, Lee BH. Neuroprotective effect of antioxidants in the brain. Int J Mol Sci 2020;21:7152.
123. Abdallah FB, Gargouri B, Bejaoui H, Lassoued S, Ammar-Keskes L. Dimethoate-induced oxidative stress in human erythrocytes and the protective effect of vitamins C and E in vitro. Environ Toxicol 2011;26:287-91.
124. Zhong W, Cruickshanks KJ, Schubert CR, et al. Carotid atherosclerosis and 10-year changes in cognitive function. Atherosclerosis 2012;224:506-10.
125. Emmerson A, Trevelin SC, Mongue-Din H, et al. Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling. J Clin Invest 2018;128:3088-101.
126. Qiu LL, Ji MH, Zhang H, et al. NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice. Brain Behav Immun 2016;51:109-18.
127. Cheon SY, Koo B. Postoperative cognitive dysfunction: advances based on pre-clinical studies. Anesth Pain Med 2018;13:113-21.
128. Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149:1060-72.
129. Masaldan S, Belaidi AA, Ayton S, Bush AI. Cellular senescence and iron dyshomeostasis in alzheimer’s disease. Pharmaceuticals 2019;12:93.
130. Fang X, Ardehali H, Min J, Wang F. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat Rev Cardiol 2023;20:7-23.
131. Jankowska EA, Kasztura M, Sokolski M, et al. Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. Eur Heart J 2014;35:2468-76.
132. Lakhal-Littleton S, Wolna M, Carr CA, et al. Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci USA 2015;112:3164-9.
133. Mancardi D, Mezzanotte M, Arrigo E, Barinotti A, Roetto A. Iron overload, oxidative stress, and ferroptosis in the failing heart and liver. Antioxidants 2021;10:1864.
136. Ma Z, Ma Y, Cao X, Zhang Y, Song T. Avenanthramide-C activates Nrf2/ARE pathway and inhibiting ferroptosis pathway to improve cognitive dysfunction in aging rats. Neurochem Res 2023;48:393-403.
137. Fu C, Wu Y, Liu S, et al. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia. J Ethnopharmacol 2022;289:115021.
138. Sun M, Li Y, Liu M, et al. Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis. Eur J Pharmacol 2023;955:175929.
139. Hanson LR, Roeytenberg A, Martinez PM, et al. Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. J Pharmacol Exp Ther 2009;330:679-86.
140. Selim M. Treatment with the iron chelator, deferoxamine mesylate, alters serum markers of oxidative stress in stroke patients. Transl Stroke Res 2010;1:35-9.
141. Rosenthal RE, Chanderbhan R, Marshall G, Fiskum G. Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine. Free Radic Biol Med 1992;12:29-33.
142. Wu H, Wu T, Xu X, Wang J, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab 2011;31:1243-50.
143. Rubbo H, O’Donnell V. Nitric oxide, peroxynitrite and lipoxygenase in atherogenesis: mechanistic insights. Toxicology 2005;208:305-17.
144. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000;69:145-82.
145. Peng M, Wang YL, Wang FF, Chen C, Wang CY. The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats. J Surg Res 2012;178:e1-8.
146. Bingham S, Beswick PJ, Blum DE, Gray NM, Chessell IP. The role of the cylooxygenase pathway in nociception and pain. Semin Cell Dev Biol 2006;17:544-54.
147. Vane JR, Mitchell JA, Appleton I, et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci U S A 1994;91:2046-50.
148. Tan XX, Qiu LL, Sun J. Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction. Biomed Res Int 2021;2021:3883204.
149. Stark DT, Bazan NG. Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. J Neurosci 2011;31:13710-21.
150. Anneken JH, Cunningham JI, Collins SA, Yamamoto BK, Gudelsky GA. MDMA increases glutamate release and reduces parvalbumin-positive GABAergic cells in the dorsal hippocampus of the rat: role of cyclooxygenase. J Neuroimmune Pharmacol 2013;8:58-65.
151. Banerjee S, Ponvel K, Sridharan G, Tangutur SP. An evidence-based review of analgesics for pain management in minor oral surgical procedures for patients predisposed to gastritis. Clin Pract 2023;20:48-57.
152. Hermanson DJ, Gamble-George JC, Marnett LJ, Patel S. Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation. Trends Pharmacol Sci 2014;35:358-67.
153. Zhu YZ, Yao R, Zhang Z, Xu H, Wang LW. Parecoxib prevents early postoperative cognitive dysfunction in elderly patients undergoing total knee arthroplasty: A double-blind, randomized clinical consort study. Medicine 2016;95:e4082.
154. Durand T, Bultel-Poncé V, Guy A, Berger S, Mueller MJ, Galano JM. New bioactive oxylipins formed by non-enzymatic free-radical-catalyzed pathways: the phytoprostanes. Lipids 2009;44:875-88.
155. Proudfoot JM, Beilin LJ, Croft KD. PGF2-isoprostanes formed during copper-induced oxidation of low-density lipoproteins are the prostaglandins that cross-react with PGE2 antibodies. Biochem Biophys Res Commun 1995;206:455-61.
156. Ray K, Fahrmann J, Mitchell B, et al. Oxidation-sensitive nociception involved in endometriosis-associated pain. Pain 2015;156:528-39.
158. Shamovsky I, Belfield G, Lewis R, et al. Theoretical studies of the second step of the nitric oxide synthase reaction: electron tunneling prevents uncoupling. J Inorg Biochem 2018;181:28-40.
159. Toro-Pérez J, Rodrigo R. Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome. Redox Rep 2021;26:35-44.
160. Andrabi SM, Sharma NS, Karan A, et al. Nitric oxide: physiological functions, delivery, and biomedical applications. Adv Sci 2023;10:e2303259.
161. Liu C, Liang MC, Soong TW. Nitric oxide, iron and neurodegeneration. Front Neurosci 2019;13:114.
162. Isik S, Yeman Kiyak B, Akbayir R, Seyhali R, Arpaci T. Microglia mediated neuroinflammation in parkinson’s disease. Cells 2023;12:1012.
163. Picón-Pagès P, Garcia-Buendia J, Muñoz FJ. Functions and dysfunctions of nitric oxide in brain. Biochim Biophys Acta Mol Basis Dis 2019;1865:1949-67.
164. Venturelli M, Pedrinolla A, Boscolo Galazzo I, et al. Impact of nitric oxide bioavailability on the progressive cerebral and peripheral circulatory impairments during aging and Alzheimer’s disease. Front Physiol 2018;9:169.
165. Leonidou A, Lepetsos P, Mintzas M, et al. Inducible nitric oxide synthase as a target for osteoarthritis treatment. Expert Opin Ther Tar 2018;22:299-318.
166. Wang B, Han S. Inhibition of Inducible nitric oxide synthase attenuates deficits in synaptic plasticity and brain functions following traumatic brain injury. Cerebellum 2018;17:477-84.
167. Askari H, Abazari MF, Ghoraeian P, et al. Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling. Metab Brain Dis 2018;33:1945-54.
168. Yin L, Gao S, Li C. Exogenous hydrogen sulfide alleviates surgery-induced neuroinflammatory cognitive impairment in adult mice by inhibiting NO signaling. BMC Anesthesiol 2020;20:12.
169. Hohenauer E. Physiological adaptions to acute hypoxia. In: Ferraz R, Neiva H, Marinho DA, Teixeira JE, Forte P, Branquinho L, editors. Exercise physiology. IntechOpen; 2022.
170. Luo Z, Tian M, Yang G, et al. Hypoxia signaling in human health and diseases: implications and prospects for therapeutics. Signal Transduct Target Ther 2022;7:218.
171. Snyder B, Simone SM, Giovannetti T, Floyd TF. Cerebral hypoxia: its role in age-related chronic and acute cognitive dysfunction. Anesth Analg 2021;132:1502-13.
172. DeSai C, Hays Shapshak A. Cerebral ischemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.
173. Hoiland RL, Bain AR, Rieger MG, Bailey DM, Ainslie PN. Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regul Integr Comp Phys 2016;310:R398-413.
174. Salameh A, Dhein S, Dähnert I, Klein N. Neuroprotective strategies during cardiac surgery with cardiopulmonary bypass. Int J Mol Sci 2016;17:1945.
176. Chung F, Liao P, Yang Y, et al. Postoperative sleep-disordered breathing in patients without preoperative sleep apnea. Anesth Analg 2015;120:1214-24.
177. Juttukonda MR, Donahue MJ. Neuroimaging of vascular reserve in patients with cerebrovascular diseases. Neuroimage 2019;187:192-208.
178. Waschke KF, Krieter H, Hagen G, Albrecht DM, Van Ackern K, Kuschinsky W. Lack of dependence of cerebral blood flow on blood viscosity after blood exchange with a Newtonian O2 carrier. J Cereb Blood Flow Metab 1994;14:871-6.
179. Aichner FT, Fazekas F, Brainin M, Pölz W, Mamoli B, Zeiler K. Hypervolemic hemodilution in acute ischemic stroke: the multicenter austrian hemodilution stroke trial (MAHST). Stroke 1998;29:743-9.
180. Iyalomhe O, Swierczek S, Enwerem N, et al. The role of hypoxia-inducible factor 1 in mild cognitive impairment. Cell Mol Neurobiol 2017;37:969-77.
181. Li T, Chen Y, Gua C, Wu B. Elevated oxidative stress and inflammation in hypothalamic paraventricular nucleus are associated with sympathetic excitation and hypertension in rats exposed to chronic intermittent hypoxia. Front Phys 2018;9:840.
182. Dayyat EA, Zhang SX, Wang Y, Cheng ZJ, Gozal D. Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea. BMC Neurosci 2012;13:77.
183. Safavynia SA, Goldstein PA. The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment. Front Psychiatry 2018;9:752.
184. Shen H, Yang J, Chen X, Gao Y, He B. Role of hypoxia-inducible factor in postoperative delirium of aged patients: a review. Medicine 2023;102:e35441.
185. Ramakrishnan S, Anand V, Roy S. Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharm 2014;9:142-60.
186. Kanazawa M, Igarashi H, Kawamura K, et al. Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment. J Cereb Blood Flow Metab 2011;31:1461-74.
187. Lee WH, Warrington JP, Sonntag WE, Lee YW. Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. Int J Radiat Oncol Biol Phys 2012;82:1559-66.
188. Simone MJ, Tan ZS. The role of inflammation in the pathogenesis of delirium and dementia in older adults: a review. CNS Neurosci Ther 2011;17:506-13.
189. Nomoto H, Pei L, Montemurro C, et al. Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes. Diabetologia 2020;63:149-61.
190. Lu C, Qiao P, Sun Y, Ren C, Yu Z. Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer. Clin Transl Med 2021;11:e400.
191. Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta 2011;1813:1263-8.
192. Egberts A, Fekkes D, Wijnbeld EH, et al. Disturbed Serotonergic neurotransmission and oxidative stress in elderly patients with delirium. Dement Geriatr Cogn Dis Extra 2015;5:450-8.
193. Wang P, Cui Y, Ren Q, et al. Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis. Cell Death Dis 2021;12:447.
194. Karlidag R, Unal S, Sezer OH, et al. The role of oxidative stress in postoperative delirium. Gen Hosp Psychiat 2006;28:418-23.
195. Li HS, Zhou YN, Li L, et al. HIF-1α protects against oxidative stress by directly targeting mitochondria. Redox Biol 2019;25:101109.
196. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci USA 2010;107:20518-22.
197. Wang C, Yue H, Hu Z, et al. Microglia mediate forgetting via complement-dependent synaptic elimination. Science 2020;367:688-94.
198. Gaikwad S, Senapati S, Haque MA, Kayed R. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: evidence from clinical and preclinical studies. Alzheimers Dement 2024;20:709-27.
199. Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011;29:139-62.
200. Sochocka M, Diniz BS, Leszek J. Inflammatory response in the CNS: friend or foe? Mol Neurobiol 2017;54:8071-89.
201. DiSabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem 2016;139 Suppl 2:136-53.
202. McManus RM, Heneka MT. Role of neuroinflammation in neurodegeneration: new insights. Alzheimers Res Ther 2017;9:14.
203. Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5:331-42.
205. López-Armada MJ, Caramés B, Lires-Deán M, et al. Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthr Cartilage 2006;14:660-9.
206. Skvarc DR, Berk M, Byrne LK, et al. Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies. Neurosci Biobehav Rev 2018;84:116-33.
207. Yin XY, Tang XH, Wang SX, et al. HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy. J Neuroinflammation 2023;20:69.
208. Ji MH, Yuan HM, Zhang GF, et al. Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early postoperative cognitive dysfunction following total hip-replacement surgery. J Anesth 2013;27:236-42.
209. Hudetz JA, Gandhi SD, Iqbal Z, Patterson KM, Pagel PS. Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery. J Anesth 2011;25:1-9.
210. Ikram FZ, Arulsamy A, Retinasamy T, Shaikh MF. The role of high mobility group box 1 (HMGB1) in neurodegeneration: a systematic review. Curr Neuropharmacol 2022;20:2221-45.
211. Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther 2023;8:267.
212. Gao ZX, Rao J, Li YH. Hyperbaric oxygen preconditioning improves postoperative cognitive dysfunction by reducing oxidant stress and inflammation. Neural Regen Res 2017;12:329-36.
213. Poh L, Sim WL, Jo DG, et al. The role of inflammasomes in vascular cognitive impairment. Mol Neurodegener 2022;17:4.
214. Wei P, Yang F, Zheng Q, Tang W, Li J. The potential role of the NLRP3 inflammasome activation as a link between mitochondria ROS generation and neuroinflammation in postoperative cognitive dysfunction. Front Cell Neurosci 2019;13:73.
215. Xie H, Yepuri N, Meng Q, et al. Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation. Rev Endocr Metab Disord 2020;21:431-47.
216. Kalkman HO, Feuerbach D. Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders. Cell Mol Life Sci 2016;73:2511-30.
217. Su X, Matthay MA, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol 2010;184:401-10.
218. Tisato V, Zauli G, Rimondi E, et al. Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells. Mediat Inflamm 2013;2013:423407.
219. Grudzińska E, Grzegorczyn S, Czuba ZP. Chemokines and growth factors produced by lymphocytes in the incompetent great saphenous vein. Mediat Inflamm 2019;2019:7057303.
220. Robinson SM, Rasch S, Beer S, et al. Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis. Sci Rep 2019;9:7318.
221. Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S. Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation. Pain 2010;149:305-15.
222. Yang Z, Simovic MO, Liu B, et al. Indices of complement activation and coagulation changes in trauma patients. Trauma Surg Acute Care Open 2022;7:e000927.
223. Zadeh FJ, Mohammadtaghizadeh M, Bahadori H, Saki N, Rezaeeyan H. The role of exogenous fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease. Mol Biol Rep 2020;47:8189-98.
224. Abdul-Muneer PM, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol 2015;51:966-79.
225. Vu T, Smith JA. An update on postoperative cognitive dysfunction following cardiac surgery. Front Psychiatry 2022;13:884907.
226. Yang J, Ran M, Li H, et al. New insight into neurological degeneration: Inflammatory cytokines and blood-brain barrier. Front Mol Neurosci 2022;15:1013933.
227. Engblom D, Ek M, Saha S, Ericsson-Dahlstrand A, Jakobsson PJ, Blomqvist A. Prostaglandins as inflammatory messengers across the blood-brain barrier. J Mol Med 2002;80:5-15.
228. Rempe RG, Hartz AMS, Bauer B. Matrix metalloproteinases in the brain and blood-brain barrier: versatile breakers and makers. J Cereb Blood Flow Metab 2016;36:1481-507.
229. Li H, Sheng Z, Khan S, et al. Matrix metalloproteinase-9 as an important contributor to the pathophysiology of depression. Front Neurol 2022;13:861843.
230. Dong H, Zhang X, Qian Y. Mast cells and neuroinflammation. Med Sci Monit Basic Res 2014;20:200-6.
231. Saxena S, Maze M. Impact on the brain of the inflammatory response to surgery. Presse Med 2018;47:e73-81.
232. Degos V, Vacas S, Han Z, et al. Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology 2013;118:527-36.
233. Schenning KJ, Murchison CF, Mattek NC, Kaye JA, Quinn JF. Sex and genetic differences in postoperative cognitive dysfunction: a longitudinal cohort analysis. Biol Sex Differ 2019;10:14.
234. Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG. MicroRNAs: roles in regulating neuroinflammation. Neuroscientist 2018;24:221-45.
235. Wang M, Su P, Liu Y, et al. Abnormal expression of circRNA_089763 in the plasma exosomes of patients with post-operative cognitive dysfunction after coronary artery bypass grafting. Mol Med Rep 2019;20:2549-62.
236. Zhou H, Li F, Ye W, et al. Correlation between plasma CircRNA-089763 and postoperative cognitive dysfunction in elderly patients undergoing non-cardiac surgery. Front Behav Neurosci 2020;14:587715.
237. Wei C, Luo T, Zou S, et al. Differentially expressed lncRNAs and miRNAs with associated ceRNA networks in aged mice with postoperative cognitive dysfunction. Oncotarget 2017;8:55901-14.
238. Shen Z, Yang Q, Luo L, et al. Non-coding RNAs identification and regulatory networks in pathogen-host interaction in the microsporidia congenital infection. BMC Genomics 2023;24:420.
239. Danan M, Schwartz S, Edelheit S, Sorek R. Transcriptome-wide discovery of circular RNAs in Archaea. Nucleic Acids Res 2012;40:3131-42.
240. You X, Vlatkovic I, Babic A, et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci 2015;18:603-10.
241. Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell 2014;56:55-66.
242. Rybak-Wolf A, Stottmeister C, Glažar P, et al. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 2015;58:870-85.
243. Hanan M, Simchovitz A, Yayon N, et al. A Parkinson’s disease CircRNAs resource reveals a link between circSLC8A1 and oxidative stress. EMBO Mol Med 2020;12:e11942.
245. Mahmoudi E, Cairns MJ. Circular RNAs are temporospatially regulated throughout development and ageing in the rat. Sci Rep 2019;9:2564.
246. Chen LL. The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol 2020;21:475-90.
247. Bao N, Liu J, Peng Z, et al. Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder. Aging 2022;14:8374-93.
248. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the rosetta stone of a hidden RNA language? Cell 2011;146:353-8.
249. Li P, Yang X, Yuan W, et al. CircRNA-Cdr1as exerts anti-oncogenic functions in bladder cancer by sponging MicroRNA-135a. Cell Physiol Biochem 2018;46:1606-16.
250. Wu F, Han B, Wu S, et al. Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p/TIPARP. J Neurosci 2019;39:7369-93.
251. Lu Y, Tan L, Wang X. Circular HDAC9/microRNA-138/Sirtuin-1 pathway mediates synaptic and amyloid precursor protein processing deficits in alzheimer's disease. Neurosci Bull 2019;35:877-88.
252. Zhang MX, Lin JR, Yang ST, et al. Characterization of circRNA-Associated-ceRNA networks involved in the pathogenesis of postoperative cognitive dysfunction in aging mice. Front Aging Neurosci 2022;14:727805.
253. Song C, Zhang Y, Huang W, et al. Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-α activity. Cell Death Differ 2022;29:393-406.
254. Gao R, Chen C, Zhao Q, et al. Identification of the potential key circular RNAs in elderly patients with postoperative cognitive dysfunction. Front Aging Neurosci 2020;12:165.
255. Wu YQ, Liu Q, Wang HB, et al. Microarray analysis identifies key differentially expressed circular RNAs in aged mice with postoperative cognitive dysfunction. Front Aging Neurosci 2021;13:716383.
256. Wu WF, Lin JT, Qiu YK, et al. The role of epigenetic modification in postoperative cognitive dysfunction. Ageing Res Rev 2023;89:101983.
258. Soreq H, Wolf Y. NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol Med 2011;17:548-55.
260. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 2017;16:203-22.
