fig3

Figure 3. Photograph of porcine heart in the Lawton laboratory following cannulation for cardiopulmonary bypass, placement of left ventricular pressure catheter, and placement of left anterior descending tourniquet for regional ischemia prior to a longer global ischemia in a model simulating clinical cardiopulmonary bypass with an acutely injured heart. Regional ischemia is evident in this porcine heart after occlusion of the left anterior descending coronary artery for 30 min for regional ischemia. Subsequently, the heart will be exposed to two hours of global ischemia protected with cardioplegia with or without diazoxide, followed by reperfusion^[136]. This model simulates the clinical situation of a patient presenting to the operating room with ongoing ischemia prior to a coronary revascularization procedure with prolonged global ischemia^[136]. This figure is used with permission from Elsevier (obtained December 12, 2023, license number 5686380805849)^[136].