fig3

Figure 3. Schematic representation of CCM2 gene and Malcavernin protein: (A) CCM2 gene structure including 10 coding exons (rectangles) and introns (horizontal lines) (reference sequence: NM_031443.3); and (B) Malcavernin protein structure, including the N-terminal phosphotyrosine binding (PTB) domain and the C-terminal Harmonin homology domain (HHD). The position of the amino acid at the beginning and at the end is indicated for each domain.