REFERENCES
1. Goldnger JZ, Halperin JL, Marin ML, Stewart AS, Eagle KA. Thoracic aortic aneurysm and dissection. Review article. J Am Coll Cardiol 2014;64:1725-39.
2. Olsson C, Thelin S, Ståhle E, Ekbom A, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. Circulation 2006;114:2611-8.
3. Howard DP, Banerjee A, Fairhead JF, Perkins J, Silver LE, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the oxford vascular study. Circulation 2013;127:2031-7.
4. Krüger T, Forkavets O, Veseli K, Lausberg H, Vöhringer L. Ascending aortic elongation and the risk of dissection. Eur J Cardiothorac Surg 2016;50:241-7.
5. Czerny M. Re: ascending aorta elongation and the risk of dissection. Eur J Cardiothorac Surg 2016;50:248.
6. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, et al. 2010 ACCF/AHA/ AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease: a report of the. American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines. American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovas- cular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. J Am Coll Cardiol 2010;55:e27-129.
7. Erbel R, Aboyans V, Boileau C, Bossone E, Di Bartolomeo R, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases. Eur Heart J 2014;35:2873-926.
8. Gagné-Loranger M, Dumont É, Voisine P, Mohammadi S, Dagenais F. Natural history of 40 50 mm root/ascending aortic aneurysms in the current era of dedicated thoracic aortic clinics. Eur J Cardiothorac Surg 2016;50:562-6.
9. Della Corte A, Bancone C, Quarto C, Dialetto G, Covino FE, et al. Predictors of ascending aortic dilatation with bicuspid aortic valve: a wide spectrum of disease expression. Eur J Cardiothorac Surg 2007;31:397-405.
10. Elefteriades JA, Ziganshin BA, Rizzo JA, Fang H, Tranquilli M, et al. Indications and imaging for aortic surgery: Size and other matters. J Thorac Cardiovasc Surg 2015;149:S10-3.
11. Gökalp AL, Takkenberg JJM. Decision-making in thoracic aortic aneurysm surgery-clinician and patient view. Semin Thorac Cardiovasc Surg 2019;31:638-42.
12. Schepens MA. Editorial comment: surgery for aneurysms of the ascending aorta: keep it simple, safe and straightforward. Eur J Cardiothorac Surg 2013;44:345.
13. Elefteriades JA, Farkas EA. Thoracic aortic aneurysm clinically pertinent controversies and uncertainties. J Am Coll Cardiol 2010;55:841-57.
14. Elefteriades JA. Indications for aortic replacement. J Thorac Cardiovasc Surg 2010;140:S5-9. discussion S45-51
15. Elefteriades JA. Natural history of thoracic aortic aneurysms: indications for surgery, and surgical versus nonsurgical risks. Ann Thorac Surg 2002;74:S1877-80. discussion S1892-8
16. Saeyeldin A, Zafar MA, Li Y, Tanweer M, Abdelbaky M, et al. Decision-making algorithm for ascending aortic aneurysm: Effectiveness in clinical application? J Thorac Cardiovasc Surg 2019;157:1733-45.
17. Mokashi SA, Svensson LG. Guidelines for the management of thoracic aortic disease in 2017. Gen Thorac Cardiovasc Surg 2019;67:59-65.
18. Pape LA, Tsai TT, Isselbacher EM, Oh JK, O’gara PT, et al; International Registry of Acute Aortic Dissection (IRAD) Investigators. Aortic diameter >or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aorti Dissection (IRAD). Circulation 2007;116:1120-7.
19. Bassano C, Vacirca SR, Colella D, Bertoldo F, Pugliese M, et al. Is the diameter of the aorta a safe parameter for cardiac surgery indication in aortic aneurysm? Proceeding of XXIX SICCH Meeting, 23-25 November 2018, Rome. J Cardiovasc Med 2018;19:8e-Supplement 2.
20. Svensson LG, Kim KH, Lytle BW, Cosgrove DM. Relationship of aortic cross-sectional area to height ratio and the risk of aortic dissection in patients with bicuspid aortic valves. J Thorac Cardiovasc Surg 2003;126:892-3.
21. Williams DM, LePage MA, Lee DY. The dissected aorta. Part I. Early anatomic changes in an in vitro model. Radiology 1997;203:23-31.
22. Neri E, Barabesi L, Buklas D, Vricella LA, Benvenuti A, et al. Limited role of aortic size in the genesis of acute type A aortic dissection. Eur J Cardiothorac Surg 2005;28:857-63.
23. Paruchuri V, Salhab KF, Kuzmik G, Gubernikoff G, Fang H, et al. Aortic size distribution in the general population: explaining the size paradox in aortic dissection. Cardiology 2015;131:265-72.
24. Davies RR, Gallo A, Coady MA, Tellides G, Botta DM, et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg 2006;81:169-77.
25. Zafar MA, Li Y, Rizzo JA, Charilaou P, Saeyeldin A, et al. Height alone, rather than body surface area, suffices for risk estimation in ascending aortic aneurysm. J Thorac Cardiovasc Surg 2018;155:1938-50.
26. Acharya MN, Youssefi P, Soppa G, Valencia O, Nowell J, et al. Analysis of aortic area/height ratio in patients with thoracic aortic aneurysm and Type A dissection. Eur J Cardiothorac Surg 2018;54:696-701.
27. Brownstein AJ, Kostiuk V, Ziganshin BA, Zafar MA, Kuivaniemi H, et al. Genes associated with thoracic aortic aneurysm and dissection: 2018 update and clinical implications. Aorta (Stamford) 2018;6:13-20.
28. Faggion Vinholo T, Brownstein AJ, Ziganshin BA, Zafar MA, Kuivaniemi H, et al. Genes associated with thoracic aortic aneurysm and dissection: 2019 update and clinical implications. Aorta (Stamford) 2019;7:99-107.
29. Ostberg NP, Zafar MA, Ziganshin BA, Elefteriades JA. The genetics of thoracic aortic aneurysms and dissection: a clinical perspective. Biomolecules 2020;10:182.
30. Ostberg NP, Zafar MA, Ziganshin BA, Elefteriades JA. The genetics of thoracic aortic aneurysms and dissection: a clinical perspective. Biomolecules 2020;10:182.
31. Homme JL, Aubry MC, Edwards WD, Bagniewski SM, Shane Pankratz V, et al. Surgical pathology of the ascending aorta: a clinicopathologic study of 513 cases. Am J Surg Pathol 2006;30:1159-68.
32. Grange T, Aubart M, Langeois M, Benarroch L, Arnaud P, et al. Quantifying the genetic basis of marfan syndrome clinical variability. Genes (Basel) 2020;11:E574.
33. Ritelli M, Colombi M. Molecular genetics and pathogenesis of ehlers-danlos syndrome and related connective tissue disorders. Genes (Basel) 2020;11:E547.
34. Fideler F, Magunia H, Grasshoff C. Cardiovascular risks in patients with loeys-dietz syndrome. Anesthesiology 2020;132:1554.
35. Zentner D, James P, Bannon P, Jeremy R. Familial aortopathies - state of the art review. Heart Lung Circ 2020;29:607-18.
36. Li T, Jing J, Sun L, Jiang B, Xin S, et al. TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases. Biosci Rep 2019;39:BSR20181591.
37. Ruvolo G, Pisano C, Candore G, Lio D, Palmeri C, et al. Can the TLR-4-mediated signaling pathway be “a key inflammatory promoter for sporadic TAA”? Mediators Inflamm 2014;2014:349476.
38. Balistreri CR, Ruvolo G, Lio D, Madonna R. Toll-like receptor-4 signaling pathway in aorta aging and diseases: “its double nature”. J Mol Cell Cardiol 2017;110:38-53.
39. Pisano C, Balistreri CR, Ricasoli A, Ruvolo G. Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease. Mediators Inflamm 2017;2017:1274034.
40. Oosterhoff LA, Kruitwagen HS, van Wolferen ME, van Balkom BWM, Mokry M, et al. Characterization of endothelial and smooth muscle cells from different canine vessels. Front Physiol 2019;10:101.
41. Bucci M, Vellecco V, Harrington L, Brancaleone V, Roviezzo F, et al. Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function. Br J Pharmacol 2013;168:411-20.
42. Romacho T, Vallejo S, Villalobos LA, Wronkowitz N, Indrakusuma I, et al. Soluble dipeptidyl peptidase-4 induces microvascular endothelial dysfunction through proteinase-activated receptor-2 and thromboxane A2 release. J Hypertens 2016;34:869-76.
43. Roy S, Saiffedine M, Loutzenisher R, Triggle CR, Hollenberg MD. Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor hereogeneity. Br J Pharmacol 1998;123:1434-40.
44. Chumachenko PV, Afanasyev MA, Ivanova AG, Drobkova IP, Kheimets GI, et al. Inflammatory infiltrates, vasa vasorum, and endothelial NO synthase in the wall of thoracic aortic aneurysm. Arkh Patol 2019;81:45-52.
45. Schmitt R, Tscheuschler A, Laschinski P, Uffelmann X, Discher P, et al. A potential key mechanism in ascending aortic aneurysm development: detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2. PLoS One 2019;14:e0212859.
46. Khanafer K, Ghosh A, Vafai K. Correlation between MMP and TIMP levels and elastic moduli of ascending thoracic aortic aneurysms. Cardiovasc Revasc Med 2019;20:324-7.
47. Tscheuschler A, Meffert P, Beyersdorf F, Heilmann C, Kocher N, et al. MMP-2 isoforms in aortic tissue and serum of patients with ascending aortic aneurysms and aortic root aneurysms. PLoS One 2016;11:e0164308.
48. Meffert P, Tscheuschler A, Beyersdorf F, Heilmann C, Kocher N, et al. Characterization of serum matrix metalloproteinase 2/9 levels in patients with ascending aortic aneurysms. Interact Cardiovasc Thorac Surg 2017;24:20-6.
49. Evans SF, Docheva D, Bernecker A, Colnot C, Richter RP, et al. Solid-supported lipid bilayers to drive stem cell fate and tissue architecture using periosteum derived progenitor cells. Biomaterials 2013;34:1878-87.
50. Li H, Qin X, Yang J, Ouyang C, Wu J, et al. Smooth muscle-specific LKB1 deletion exaggerates angiotensin II-induced abdominal aortic aneurysm in mice. J Mol Cell Cardiol 2019;130:131-9.
51. Scola L, Di Maggio FM, Vaccarino L, Bova M, Forte GI. Role of TGF-β pathway polymorphisms in sporadic thoracic aortic aneurysm: rs900 TGF-β2 is a marker of differential gender susceptibility. Mediators Inflamm 2014;2014:165758.
52. Balistreri CR, Madonna R, Melino G, Caruso C. The emerging role of Notch pathway in ageing: focus on the related mechanisms in age-related diseases. Ageing Res Rev 2016;29:50-65.
53. Balistreri CR, Crapanzano F, Schirone L, Allegra A, Pisano C, et al. Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascending aorta aneurysm. Sci Rep 2018;8:13834.
54. Cesarini V, Pisano C, Rossi G, Balistreri CR, Botti F, et al. Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms. Sci Rep 2019;9:12206.
55. Balistreri CR, Maresi E, Pisano C, Di Maggio FM, Vaccarino L, et al. Identification of three particular morphological phenotypes in sporadic thoracic aortic aneurysm: phenotype III as sporadic thoracic aortic aneurysm biomarker in aged individuals. Rejuvenation Res 2014;17:192-6.
56. Balistreri CR, Pisano C, Candore G, Maresi E, Codispoti M, et al. Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinical implications of a pilot study. Eur J Cardiothorac Surg 2013;43:e180-6.
57. Pisano C, Maresi E, Merlo D, Balistreri CR, Candore G, et al. A particular phenotype of ascending aorta aneurysms as precursor of type A aortic dissection. Interact Cardiovasc Thorac Surg 2012;15:840-6.
58. Pisano C, Maresi E, Balistreri CR, Candore G, Merlo D, et al. Histological and genetic studies in patients with bicuspid aortic valve and ascending aorta complications. Interact Cardiovasc Thorac Surg 2012;14:300-6.
59. Nardi P, Pellegrino A, Russo M, Saitto G, Bertoldo F, et al. Mid-term results of different surgical techniques to replace the ascending aorta associated with bicuspid aortic valve disease. Ann Thorac Surg 2013;96:1648-55.
60. Krüger T, Forkavets O, Veseli K, Lausberg H, Vöhringer L, et al. Ascending aortic elongation and the risk of dissection. Eur J Cardiothorac Surg 2016;50:241-7.
61. Wu J, Zafar MA, Li Y, Saeyeldin A, Huang Y, et al. Ascending aortic length and risk of aortic adverse events: the neglected dimension. J Am Coll Cardiol 2019;74:1883-94.
62. Heuts S, Adriaans BP, Rylski B, Mihl C, Bekkers SCAM, et al. Evaluating the diagnostic accuracy of maximal aortic diameter, length and volume for prediction of aortic dissection. Heart 2020;106:892-7.
63. Fels B, Kusche-Vihrog K. It takes more than two to tango: mechanosignaling of the endothelial surface. Pflugers Arch 2020;472:419-33.
64. Nardi P, Ruvolo G. Current indications to surgical repair of the aneurysms of ascending aorta. J Vascular Endovascular Surgery 2016;1:9.
65. Barker AJ, Markl M, Bürk J, Lorenz R, Bock J, et al. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging 2012;5:457-66.
66. Bissell MM, Hess AT, Biasiolli L, Glaze SJ, Loudon M, et al. Aortic dilation inbicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type. Circ Cardiovasc Imaging 2013;6:499-507.
67. Mahadevia R, Barker AJ, Schnell S, Entezari P, Kansal P, et al. Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress and expression of aortopathy. Circulation 2014;129:673-82.
68. Della Corte A, Quarto C, Bancone C, Castaldo C, Di Meglio F, et al. Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling. J Thorac Cardiovasc Surg 2008;135:8-18. 18.e1-2
69. Guzzardi DG, Barker AJ, van Ooij P, Malaisrie SC, Puthumana JJ, et al. Valve-related hemodynamics mediate human bicuspid aortopathy: insights from wall shear stress mapping. J Am Coll Cardiol 2015;66:892-900.