REFERENCES
1. La Padula S, Ponzo M, Lombardi M, et al. Nanofat in plastic reconstructive, regenerative, and aesthetic surgery: a review of advancements in face-focused applications. J Clin Med. 2023;12:4351.
2. Ghosh K, Patel RA, Hanson SE. Cell-supplemented autologous fat grafting: a review from bench to bedside. Plast Aesthet Res 2024;11:50.
3. Choudhery MS, Arif T, Afzal A, Mahmood R. Therapeutic potential of adipose tissue in aesthetic medicine. World J Exp Med. 2025;15:106641.
4. Sendera A, Kubis H, Pałka A, Banaś-Ząbczyk A. Therapeutic and clinical potential of adipose-derived stem cell secretome for skin regeneration. Cells. 2025;14:1727.
5. Han X, Ji D, Liu Y, Hu S. Efficacy and safety of transplantation of autologous fat, platelet-rich plasma (PRP) and stromal vascular fraction (SVF) in the treatment of acne scar: systematic review and meta-analysis. Aesthetic Plast Surg. 2023;47:1623-32.
6. Cui L, Lyu TJ, Fu B, et al. Advances and challenges in decellularized adipose tissue based composite hydrogels for adipose tissue regeneration: a review over the last fifteen years. Theranostics. 2025;15:9508-32.
7. Xiong S, Ji J, Cheng W, Pang Q, Lin C, Wei P. Targeting ferroptosis in photoaging: mechanisms and therapeutic potential of adipose-derived stem cell exosomes. Plast Aesthet Res 2026;13:9.
8. Melnick BA, Abu-Romman A, Fine KS, et al. Decellularized adipose matrix for soft tissue regeneration: enhancing angiogenesis and adipogenesis. Tissue Eng Part B Rev. 2026;32:29-43.
9. Liang W, Han M, Li G, et al. Perfusable adipose decellularized extracellular matrix biological scaffold co-recellularized with adipose-derived stem cells and L6 promotes functional skeletal muscle regeneration following volumetric muscle loss. Biomaterials. 2024;307:122529.
10. Acharya P, Mohammed C, Desai A, et al. Maximizing the longevity and volume retention of fat grafts: advances in clinical practice. Cureus. 2025;17:e88493.
11. Choudhery MS, Niaz A, Arif T, Mahmood R. Adipose tissue as a living drug: stromal vascular fraction and adipose tissue-derived stem cells in regenerative medicine. World J Stem Cells. 2025;17:114170.
12. Zhao XY, Li PC, Chen YM, et al. Adipose tissue engineering biomaterials: smart scaffolds, vascularization, and clinical frontiers. Biomolecules. 2026;16:362.
13. Liu J, Li Y, Zhang Y, Zhao Z, Liu B. Engineered stromal vascular fraction for tissue regeneration. Front Pharmacol. 2025;16:1510508.
14. Su H, Chau H, Li Q, et al. Bridging the gap: clinical translation of adipose-derived stem cells - a scoping review of clinical trials. Stem Cell Res Ther. 2025;16:288.
15. Piejko M, Hinz A, Mak P, et al. Rapidly decellularized adipose tissue induces soft tissue vascularization in potential anatomical spaces. BMC Biotechnol. 2025;25:109.
16. Pruzzo V, Bonomi F, Limido E, Weinzierl A, Harder Y, Laschke MW. Injectable scaffolds for adipose tissue reconstruction. Gels. 2026;12:81.
17. Nonnarath C, Serratrice N. Safety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review. Stem Cell Res Ther. 2026;17:90.
18. Wang L, Jiang X, Zhao F, Duan P, Li Z, Luo Y. A review of adipose-derived mesenchymal stem cells’ impacts and challenges: metabolic regulation, tumor modulation, immunomodulation, regenerative medicine and genetic engineering therapies. Front Endocrinol. 2025;16:1606847.
19. Papadopoulos KS, Piperi C, Korkolopoulou P. Clinical applications of adipose-derived stem cell (ADSC) exosomes in tissue regeneration. Int J Mol Sci. 2024;25:5916.
20. Sun M, He Y, Zhou T, Zhang P, Gao J, Lu F. Adipose extracellular matrix/stromal vascular fraction gel secretes angiogenic factors and enhances skin wound healing in a murine model. Biomed Res Int. 2017;2017:3105780.
21. Gandolfi S, Lupon E, Varin A, et al. Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions. Biol Direct. 2025;20:95.
22. Cremona M, Gallazzi M, Rusconi G, Mariotta L, Gola M, Soldati G. State of the art in the standardization of stromal vascular fraction processing. Biomolecules. 2025;15:199.
23. Sforza M, Ivanenko O, Biabani N, et al. Mechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysis. Stem Cell Res Ther. 2025;16:560.
24. Schwitzguebel A, Ramirez Cadavid DA, Da Silva T, Decavel P, Benaim C. Effectiveness of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) in patients with knee osteoarthritis: protocol for a phase 3, prospective, randomized, controlled, multicenter study (SPOST Study). JMIR Res Protoc. 2025;14:e62659.
25. Jeyaraman M, Muthu S, Sharma S, Ganta C, Ranjan R, Jha SK. Nanofat: a therapeutic paradigm in regenerative medicine. World J Stem Cells. 2021;13:1733-46.
26. Arcani R, Abellan M, Simoncini S, et al. First comparison of commercial systems to prepare nanofat: technical performances and biological quality differ among obtained products. Sci Rep. 2026;16:9998.
27. Cicione C, Vadalà G, Di Giacomo G, et al. Micro-fragmented and nanofat adipose tissue derivatives: In vitro qualitative and quantitative analysis. Front Bioeng Biotechnol. 2023;11:911600.
28. Wrublewsky S, Bickelmann C, Meßmer LS, et al. Boosting the engraftment of subcutaneously transplanted pancreatic islets by nanofat. Diabetes Obes Metab. 2025;27:7258-74.
29. Pruzzo V, Bonomi F, Limido E, Weinzierl A, Harder Y, Laschke MW. Seeding of dermal substitutes with glucose-pretreated nanofat accelerates in vivo vascularization and tissue integration. J Funct Biomater. 2025;16:311.
30. Zare S, Jafarzadeh A, Zare S, Shamloo A. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review. Stem Cell Res Ther. 2025;16:177.
31. Yao Y, Dong Z, Liao Y, et al. Adipose extracellular matrix/stromal vascular fraction gel: a novel adipose tissue-derived injectable for stem cell therapy. Plast Reconstr Surg. 2017;139:867-79.
32. Liu J, Wang J, Zhang Q, Lu F, Cai J. Clinical, histologic, and transcriptomic evaluation of sequential fat grafting for morphea: a nonrandomized controlled trial. JAMA Dermatol. 2024;160:425-33.
33. You X, Gao J, Yao Y. Advanced methods to mechanically isolate stromal vascular fraction: a concise review. Regen Ther. 2024;27:120-5.
34. Goncharov EN, Koval OA, Igorevich EI, et al. Analyzing the clinical potential of stromal vascular fraction: a comprehensive literature review. Medicina. 2024;60:221.
35. Wu J, Wang Y, Chen W, et al. Harnessing stromal vascular fraction-based therapies for wound healing: mechanisms, synergies, and clinical translation. Regen Ther. 2025;30:692-709.
36. Ni X, Xu N, Shen J, et al. SVF-gel application for the alleviation of full-thickness skin graft contraction: an experimental study in mice. Sci Rep. 2025;15:15082.
37. Deng M, Wang X, Yu Z, et al. Cell-free fat extract promotes tissue regeneration in a tissue expansion model. Stem Cell Res Ther. 2020;11:50.
38. Wei Z, Zhang M, Chen M, Song Y, Wang Y. Effects of cell-free fat extract and platelet-rich fibrin on scar maturation in an experimental rabbit ear wound model. Clin Cosmet Investig Dermatol. 2024;17:2901-9.
39. Xu C, Zhou X, Yang C, Zhou F, Xie Y. Cell-free fat extract for the treatment of lumbar disc degeneration: a novel approach using adipose-derived biologic. Biomedicines. 2025;13:1344.
40. Xie Y, Wu W, Wu D, Zhao L, Wen D. Cell-free fat extract promotes cornea epithelial repair and restores neurodegeneration via an anti-inflammation pathway. FASEB J. 2025;39:e71176.
41. Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W. Annexin A5 derived from cell-free fat extract attenuates osteoarthritis via macrophage regulation. Int J Biol Sci. 2024;20:2994-3007.
42. Ru J, Zhang Q, Zhu S, Cai J, He Y, Lu F. Delivery of adipose-derived growth factors from heparinized adipose acellular matrix accelerates wound healing. Front Bioeng Biotechnol. 2023;11:1270618.
43. Cai Y, Jia Z, Zhang Y, et al. Cell-free fat extract restores hair loss: a novel therapeutic strategy for androgenetic alopecia. Stem Cell Res Ther. 2023;14:219.
44. Huang S, Rao Y, Ju AL, et al. Non-collagenous proteins, rather than the collagens, are key biochemical factors that mediate tenogenic bioactivity of tendon extracellular matrix. Acta Biomater. 2024;176:99-115.
45. Nie M, Li X, Xiao Y, Lei S, Wu D. A novel strategy for preparation of ADSCs-osteogenic microtissue based on CEFFE and mechanisms for enhancing osteogenic activity. FASEB J. 2025;39:e70996.
46. Lu C, Cai J, Lu F. Innovative adipose tissue fractionation for transforming fat into specialized components. J Vis Exp 2025.
47. Cai J, He Y, Liao Y, et al. Adipose component transplantation: an advanced fat-grafting strategy for facial rejuvenation. Plast Reconstr Surg. 2024;153:549e-54.
48. Li Y, Zhang P, Zhang X, et al. Adipose matrix complex: a high-rigidity collagen-rich adipose-derived material for fat grafting. Aging. 2021;13:14910-23.
49. Adem S, Abbas DB, Lavin CV, et al. Decellularized adipose matrices can alleviate radiation-induced skin fibrosis. Adv Wound Care. 2022;11:524-36.
50. Mehta MKS, Englander HE, Rao A, Jarostchuk N, Giatsidis G. Acellular adipose matrices seem to be an effective and safe strategy for soft tissue regeneration and volume restoration: a systematic review of clinically relevant literature. Adv Wound Care. 2025;14:513-27.
51. Jin X, Zhang Y, Zhang X, et al. An adipose-derived injectable sustained-release collagen scaffold of adipokines prepared through a fast mechanical processing technique for preventing skin photoaging in mice. Front Cell Dev Biol. 2021;9:722427.
52. Zhang Y, Zhang X, Jin X, et al. Adipose collagen fragment: a novel adipose-derived extracellular matrix concentrate for skin filling. Aesthet Surg J. 2022;42:NP337-50.
53. Xu M, He Y, Li Y, et al. Combined use of autologous sustained-release scaffold of adipokines and acellular adipose matrix to construct vascularized adipose tissue. Plast Reconstr Surg. 2024;153:348e-60.
54. Choi JS, Kim BS, Kim JY, et al. Decellularized extracellular matrix derived from human adipose tissue as a potential scaffold for allograft tissue engineering. J Biomed Mater Res A. 2011;97:292-9.
55. Song M, Liu Y, Hui L. Preparation and characterization of acellular adipose tissue matrix using a combination of physical and chemical treatments. Mol Med Rep. 2018;17:138-46.
56. Song M, Zhou Y, Liu Y. VEGF heparinized-decellularized adipose tissue scaffolds enhance tissue engineering vascularization in vitro. RSC Adv. 2018;8:33614-24.
57. Yang JZ, Qiu LH, Xiong SH, et al. Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration. World J Stem Cells. 2020;12:585-603.
58. Tang W, Qi J, Wang Q, Qu Y, Fu S, Luan J. Investigating the adipogenic effects of different tissue-derived decellularized matrices. Front Bioeng Biotechnol. 2022;10:872897.
59. Shih YY, Kao CW, Jhong YR, Chen YA, Chen YW. Synergistic effects of fibrin-enriched adipose decellularized extracellular matrix (AdECM) and microfluidic model on vascularization. RSC Adv. 2024;14:34143-55.
60. Wang Z, Liang W, Ao R, An Y. Adipose decellularized matrix: a promising skeletal muscle tissue engineering material for volume muscle loss. Biomater Res. 2025;29:0174.
61. Flynn LE. The use of decellularized adipose tissue to provide an inductive microenvironment for the adipogenic differentiation of human adipose-derived stem cells. Biomaterials. 2010;31:4715-24.
62. Hou M, Shi N, Guo Y, et al. Autologous extracellular matrix-based cell-free therapy for tissue regeneration through Trem2+ macrophages mediated angiogenesis. Exploration. 2026;6:20250031.
63. Yang J, Tang J, Dang J, et al. Bioactive decellularized adipose matrix prepared using a rapid, nonchemical/enzymatic method for adipogenesis. Biotechnol Bioeng. 2024;121:157-75.
64. Zhang J, Xiang Y, Yang Q, et al. Adipose-derived stem cells derived decellularized extracellular matrix enabled skin regeneration and remodeling. Front Bioeng Biotechnol. 2024;12:1347995.
65. Capella-Monsonís H, De Pieri A, Peixoto R, Korntner S, Zeugolis DI. Extracellular matrix-based biomaterials as adipose-derived stem cell delivery vehicles in wound healing: a comparative study between a collagen scaffold and two xenografts. Stem Cell Res Ther. 2020;11:510.
66. Hyldig K, Riis S, Pennisi CP, Zachar V, Fink T. Implications of extracellular matrix production by adipose tissue-derived stem cells for development of wound healing therapies. Int J Mol Sci. 2017;18:1167.
68. Qian Y, Chen H, Pan T, et al. Autologous decellularized extracellular matrix promotes adipogenic differentiation of adipose derived stem cells in low serum culture system by regulating the ERK1/2-PPARγ pathway. Adipocyte. 2021;10:174-88.
69. Anderson AE, Wu I, Parrillo AJ, et al. An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial. NPJ Regen Med. 2022;7:6.
70. Bi X, Li Y, Dong Z, et al. Recent developments in extracellular matrix remodeling for fat grafting. Front Cell Dev Biol. 2021;9:767362.
71. Liang B, Bai R, Wang J, et al. Innovative applications of acellular adipose matrix derived film in skin soft tissue expansion. Biomater Adv. 2025;173:214291.
72. Saldin LT, Cramer MC, Velankar SS, White LJ, Badylak SF. Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomater. 2017;49:1-15.
73. Pu W, Han Y, Yang M. Human decellularized adipose tissue hydrogels as a culture platform for human adipose-derived stem cell delivery. J Appl Biomater Funct Mater. 2021;19:2280800020988141.
74. Tan QW, Zhang Y, Luo JC, et al. Hydrogel derived from decellularized porcine adipose tissue as a promising biomaterial for soft tissue augmentation. J Biomed Mater Res A. 2017;105:1756-64.
75. Chen Z, Zhang B, Shu J, et al. Human decellularized adipose matrix derived hydrogel assists mesenchymal stem cells delivery and accelerates chronic wound healing. J Biomed Mater Res A. 2021;109:1418-28.
76. Spang MT, Christman KL. Extracellular matrix hydrogel therapies: in vivo applications and development. Acta Biomater. 2018;68:1-14.
77. Kim SH, Kim D, Cha M, Kim SH, Jung Y. The regeneration of large-sized and vascularized adipose tissue using a tailored elastic scaffold and dECM hydrogels. Int J Mol Sci. 2021;22:12560.
78. Lee MH, Kang BY, Wong CC, et al. A systematic review of autologous adipose-derived stromal vascular fraction (SVF) for the treatment of acute cutaneous wounds. Arch Dermatol Res. 2022;314:417-25.
79. Feng H, Gong S, Liu J, et al. Adipose-derived stem cell exosomes: mechanisms and therapeutic potentials in wound healing. Biomark Res. 2025;13:88.
80. Wongkietkachorn A, Wongkietkachorn N. Efficacy of nanofat in wound healing: a double-blinded randomized controlled trial. Plast Reconstr Surg. 2026;157:994-9.
81. Bonomi F, Limido E, Weinzierl A, et al. Nanofat improves vascularization and tissue integration of dermal substitutes without affecting their biocompatibility. J Funct Biomater. 2024;15:294.
82. Zeng Y, Sun D, Wang R, An R, Sun J, Yang J. Lipid droplet-free nanovesicles extruded from stromal vascular fraction improve adipocyte regeneration in the centre of dermal graft. Stem Cell Res Ther. 2025;16:114.
83. Cai Y, Zhang F, Feng J, et al. Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds. Stem Cell Res Ther. 2023;14:163.
84. Vuerich R, Groppa E, Vodret S, et al. Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels. NPJ Regen Med. 2023;8:8.
85. Zhang C, Jiang T, Jiang G, et al. White adipose tissue-derived small extracellular vesicles: a new potential therapeutic reagent for accelerating diabetic wound healing. FASEB J. 2023;37:e23314.
86. Farabi B, Roster K, Hirani R, Tepper K, Atak MF, Safai B. The efficacy of stem cells in wound healing: a systematic review. Int J Mol Sci. 2024;25:3006.
87. Suh JH, Kim JY, Yoon JY, et al. Comparison of efficacy of intradermal stromal vascular fraction injection versus saline injection in the treatment of atrophic acne scar: a 10-week, prospective, randomized, split-face, single-blind controlled trial. Dermatol Ther 2025; Epub ahead of print.
88. Alxaneder R. Overview of use of nanofat (fully emulsified tSVF + HD platelet-rich plasma (PRP) in aesthetic and regenerative medicine cases. MRAJ. 2025;13:1-22.
89. Chen W, Su W, Bi D, et al. Cell-free fat extract (Ceffe) combined with GelMA hydrogel to improve the survival rate of random skin flaps in mice. ACS Biomater Sci Eng. 2025;11:4177-92.
90. Wang M, Zhao J, Li J, Meng M, Zhu M. Insights into the role of adipose-derived stem cells and secretome: potential biology and clinical applications in hypertrophic scarring. Stem Cell Res Ther. 2024;15:137.
91. Balko S, Kerr E, Buchel E, Logsetty S, Raouf A. Paracrine signalling between keratinocytes and SVF cells results in a new secreted cytokine profile during wound closure. Stem Cell Res Ther. 2023;14:258.
92. Roohaninasab M, Khodadad F, Sadeghzadeh-Bazargan A, et al. Efficacy of fractional CO2 laser in combination with stromal vascular fraction (SVF) compared with fractional CO2 laser alone in the treatment of burn scars: a randomized controlled clinical trial. Stem Cell Res Ther. 2023;14:269.
93. Alfarafisa NM, Chou Y, Santika R, Riestiano BE, Soedjana H, Syamsunarno MRAA. Adipose-derived stem cell products and combination therapies for the treatment of pathological scars: a review of current preclinical and clinical studies. Clin Cosmet Investig Dermatol. 2025;18:1309-37.
94. Fanniel V, Atawneh I, Savoie J, et al. Advancing soft tissue reconstruction with a ready-to-use human adipose allograft. Bioengineering. 2025;12:612.
95. Shimizu Y, Inoue Y, Sowa Y, et al. Adipose-derived stem cell-enhanced versus conventional fat grafting for breast reconstruction: a systematic review and meta-analysis. Plast Reconstr Surg. 2026;157:338e-49.
96. Kim DY, Hwang DY, Park G, et al. Adipose-derived dual cell therapy enhances arteriogenesis and limb preservation through vascular integration in critical limb ischemia. NPJ Regen Med. 2026;11:13.
97. Biniazan F, Stoian A, Haykal S. Adipose-derived stem cells: angiogenetic potential and utility in tissue engineering. Int J Mol Sci. 2024;25:2356.
98. Stachura A, Paskal W, Pawlik W, Mazurek MJ, Jaworowski J. The use of adipose-derived stem cells (ADSCs) and stromal vascular fraction (SVF) in skin scar treatment-a systematic review of clinical studies. J Clin Med. 2021;10:3637.
99. Lee H, Lim Y, Lee SH. Rapid-acting pain relief in knee osteoarthritis: autologous-cultured adipose-derived mesenchymal stem cells outperform stromal vascular fraction: a systematic review and meta-analysis. Stem Cell Res Ther. 2024;15:446.
100. Boada-Pladellorens A, Avellanet M, Veiga A, Pages-Bolibar E. Efficacy of stromal vascular fraction treatment for knee osteoarthritis: a single-arm experimental trial. Biomedicines. 2025;13:2913.
101. Yuan C, Song W, Jiang X, et al. Adipose-derived stem cell-based optimization strategies for musculoskeletal regeneration: recent advances and perspectives. Stem Cell Res Ther. 2024;15:91.
102. Zhang H, Felthaus O, Prantl L. Adipose tissue-derived therapies for osteoarthritis: multifaceted mechanisms and clinical prospects. Cells. 2025;14:669.
103. Sharma S, Muthu S, Jeyaraman M, Ranjan R, Jha SK. Translational products of adipose tissue-derived mesenchymal stem cells: Bench to bedside applications. World J Stem Cells. 2021;13:1360-81.
104. Senesi L, De Francesco F, Marchesini A, et al. Efficacy of adipose-derived mesenchymal stem cells and stromal vascular fraction alone and combined to biomaterials in tendinopathy or tendon injury: systematic review of current concepts. Medicina. 2023;59:273.
105. Sun Y, Chen D, Dai T, et al. Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy. Front Cell Neurosci. 2024;18:1344853.
106. Quintero Sierra LA, Biswas R, Conti A, et al. Highly pluripotent adipose-derived stem cell-enriched nanofat: a novel translational system in stem cell therapy. Cell Transplant. 2023;32:9636897231175968.
107. Epanomeritakis IE, Khan WS. Adipose-derived regenerative therapies for the treatment of knee osteoarthritis. World J Stem Cells. 2024;16:324-33.
108. Moreira HR, Rodrigues DB, Freitas-Ribeiro S, et al. Spongy-like hydrogels prevascularization with the adipose tissue vascular fraction delays cutaneous wound healing by sustaining inflammatory cell influx. Mater Today Bio. 2022;17:100496.
109. Zhang M, Zhao F, Zhu Y, et al. Physical properties and biochemical composition of extracellular matrix-derived hydrogels dictate vascularization potential in an organ-dependent fashion. ACS Appl Mater Interfaces. 2024;16:29930-45.
110. Agaverdiev M, Shamsov B, Mirzoev S, et al. MiRNA regulated therapeutic potential of the stromal vascular fraction: current clinical applications - a systematic review. Noncoding RNA Res. 2023;8:146-54.
111. Stampouli K, Papadimitriou L, García-lizarribar A, Madarieta I, Olalde B, Ranella A. Adipose tissue-derived ECM hydrogels as a 3D platform for neural differentiation and brain diseases. Mater Adv 2025;6:7884-94.
112. Yao WD, Zhou JN, Tang C, et al. Hydrogel microneedle patches loaded with stem cell mitochondria-enriched microvesicles boost the chronic wound healing. ACS Nano. 2024;18:26733-50.
113. Asch A, Kalbermatten DF, Madduri S. Clinical safety and efficacy of allogeneic adipose stem cells: a systematic review of the clinical trials. Int J Mol Sci. 2025;26:6376.
114. Xiao Y, Liao Z, Zhang H, Guan T. The global regulatory landscape of stem cell medical aesthetics: challenges, comparisons, and pathways to coordination. Stem Cells Transl Med. 2026;15:szaf079.
115. Jeyaraman N, Shrivastava S, Rangarajan RV, et al. Challenges in the clinical translation of stromal vascular fraction therapy in regenerative medicine. World J Stem Cells. 2025;17:103775.
116. Haskett DG, Saleh KS, Lorentz KL, et al. An exploratory study on the preparation and evaluation of a “same-day” adipose stem cell-based tissue-engineered vascular graft. J Thorac Cardiovasc Surg. 2018;156:1814-22.e3.
117. Rasekh M, Arshad MS, Ahmad Z. Advances in drug delivery integrated with regenerative medicine: innovations, challenges, and future frontiers. Pharmaceutics. 2025;17:456.
