REFERENCES
1. Zarbafian M, Fabi SG, Dayan S, Goldie K. The emerging field of regenerative aesthetics-where we are now. Dermatol Surg. 2022;48:101-8.
3. Trovato F, Ceccarelli S, Michelini S, et al. Advancements in regenerative medicine for aesthetic dermatology: a comprehensive review and future trends. Cosmetics. 2024;11:49.
4. Samadi P, Sheykhhasan M, Khoshinani HM. The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic Plast Surg. 2019;43:803-14.
5. Leo MS, Kumar AS, Kirit R, Konathan R, Sivamani RK. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol. 2015;14:315-23.
6. Gupta S, Paliczak A, Delgado D. Evidence-based indications of platelet-rich plasma therapy. Expert Rev Hematol. 2021;14:97-108.
7. Justicz N, Derakhshan A, Chen JX, Lee LN. Platelet-rich plasma for hair restoration. Facial Plast Surg Clin North Am. 2020;28:181-7.
8. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21:7794.
9. Asubiaro J, Avajah F. Platelet-rich plasma in aesthetic dermatology: current evidence and future directions. Cureus. 2024;16:e66734.
10. Lin MY, Lin CS, Hu S, Chung WH. Progress in the use of platelet-rich plasma in aesthetic and medical dermatology. J Clin Aesthet Dermatol. 2020;13:28-35.
11. Elghblawi E. Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. J Cosmet Dermatol. 2018;17:423-30.
12. Maurizio C, Marco P. Long chain polynucleotides gel and skin biorevitalization. Available from: https://www.agfarma.com/wp-content/uploads/2025/01/2007-Cavallini-Papagni-JPD-Long-chain-polynucleotides-gel-ans-skin-biorivitalization-Plinest-143-pts.pdf. [Last accessed on 28 Jan 2026].
13. Bartoletti E, Cavallini M, Maioli L, et al. Introduction to polynucleotides highly purified technology. Available from: https://www.researchgate.net/publication/365759324_Introduction_to_polynucleotides_highly_purified_technology. [Last accessed on 28 Jan 2026].
14. Bartoletti E, Trocchi G. Polynucleotides highly purified technology, the new class of body skin biorevitalizing agents. Available from: https://www.agfarma.com/wp-content/uploads/2025/01/2021-NR-4-BARTOLETTI-TROCCHI-AEM-narrative-PN-body-skin.pdf. [Last accessed on 28 Jan 2026].
15. Lee KWA, Chan KWL, Lee A, et al. Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness. Int J Mol Sci. 2024;25:8224.
16. Brandi C, Cuomo R, Nisi G, Grimaldi L, D’Aniello C. Face rejuvenation: a new combinated protocol for biorevitalization. Acta Biomed. 2018;89:400-5.
17. Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPTTM (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol. 2021;20:922-8.
18. Maioli L. Polynucleotides highly purified technology and nucleotides for the acceleration and regulation of normal wound healing. Available from: https://www.agfarma.com/wp-content/uploads/2025/01/2020-NR-2-Maioli-L.-Polynucleotides-HPT-and-nucleotides-for-the-acceleration-and-regulation-of-normal-wound-healing.pdf. [Last accessed on 28 Jan 2026].
19. Lampridou S, Bassett S, Cavallini M, Christopoulos G. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24:e16721.
20. Massirone A. Polynucleotides highly purified technology and the face skin, a history of innovative skin priming. Available from: https://www.ami.co.il/wp-content/uploads/2025/10/2021-NR-3-MASSIRONE-AEM-narrative-PN-face-skin.pdf. [Last accessed on 28 Jan 2026].
21. Lee DK, Oh M, Kim MJ, Oh SM. Clinical effects of polynucleotide with hyaluronic acid intradermal injections on facial erythema: effective redness treatment using polynucleotides. Skin Res Technol. 2024;30:e70034.
22. Vyas KS, Kaufman J, Munavalli GS, Robertson K, Behfar A, Wyles SP. Exosomes: the latest in regenerative aesthetics. Regen Med. 2023;18:181-94.
23. Zhang B, Gong J, He L, et al. Exosomes based advancements for application in medical aesthetics. Front Bioeng Biotechnol. 2022;10:1083640.
24. Olumesi KR, Goldberg DJ. A review of exosomes and their application in cutaneous medical aesthetics. J Cosmet Dermatol. 2023;22:2628-34.
25. Xiong M, Zhang Q, Hu W, et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacol Res. 2021;166:105490.
26. Ha DH, Kim HK, Lee J, et al. Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration. Cells. 2020;9:1157.
28. Bernardini FP, Gennai A, Izzo L, et al. Superficial enhanced fluid fat injection (SEFFI) to correct volume defects and skin aging of the face and periocular region. Aesthet Surg J. 2015;35:504-15.
29. Gennai A, Zambelli A, Repaci E, et al. Skin rejuvenation and volume enhancement with the micro superficial enhanced fluid fat injection (M-SEFFI) for skin aging of the periocular and perioral regions. Aesthet Surg J. 2017;37:14-23.
30. Neuber F. Fettransplantation. Bericht uber die Verhandlungen der Deutschen Gesellschaft fur Chirurgie. (in German) Available from: https://cir.nii.ac.jp/crid/1581980076082320896. [Last accessed on 28 Jan 2026].
31. Pu LL, Yoshimura K, Coleman SR. Future perspectives of fat grafting. Clin Plast Surg. 2015;42:389-94.
32. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279-95.
33. Frese L, Dijkman PE, Hoerstrup SP. Adipose tissue-derived stem cells in regenerative medicine. Transfus Med Hemother. 2016;43:268-74.
34. Trivisonno A, Di Rocco G, Cannistra C, et al. Harvest of superficial layers of fat with a microcannula and isolation of adipose tissue-derived stromal and vascular cells. Aesthet Surg J. 2014;34:601-13.
35. Wazer DE. 4-45 clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Breast Dis Year Book Q. 2008;18:393-4.
36. Nguyen PS, Desouches C, Gay AM, Hautier A, Magalon G. Development of micro-injection as an innovative autologous fat graft technique: the use of adipose tissue as dermal filler. J Plast Reconstr Aesthet Surg. 2012;65:1692-9.
37. Capuana E, Lopresti F, Ceraulo M, La Carrubba V. Poly-L-lactic acid (PLLA)-based biomaterials for regenerative medicine: a review on processing and applications. Polymers. 2022;14:1153.
38. Christen MO. Collagen stimulators in body applications: a review focused on Poly-L-lactic acid (PLLA). Clin Cosmet Investig Dermatol. 2022;15:997-1019.
39. Ao YJ, Yi Y, Wu GH. Application of PLLA (Poly-L-lactic acid) for rejuvenation and reproduction of facial cutaneous tissue in aesthetics: a review. Medicine. 2024;103:e37506.
40. Bravo BSF, Calvacante T, Nobre CS, Bravo LG, Zafra MC, Elias MC. Exploring the safety and satisfaction of patients injected with collagen biostimulators-a prospective investigation into injectable Poly-L-lactic acid (PLLA). J Cosmet Dermatol. 2025;24:e16723.
41. Oh S, Lee JH, Kim HM, et al. Poly-L-lactic acid fillers improved dermal collagen synthesis by modulating M2 macrophage polarization in aged animal skin. Cells. 2023;12:1320.
42. Sedush NG, Kalinin KT, Azarkevich PN, Gorskaya AA. Physicochemical characteristics and hydrolytic degradation of polylactic acid dermal fillers: a comparative study. Cosmetics. 2023;10:110.
43. Zhu W, Dong C. Poly-L-lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway. J Cosmet Dermatol. 2023;22:1213-9.
44. Zou Y, Cao M, Tai M, et al. A feedback loop driven by H4K12 lactylation and HDAC3 in macrophages regulates lactate-induced collagen synthesis in fibroblasts via the TGF-β signaling. Adv Sci. 2025;12:e2411408.
45. Chirumbolo S, Bertossi D, Magistretti P. Insights on the role of L-lactate as a signaling molecule in skin aging. Biogerontology. 2023;24:709-26.
46. Baranov MV, Kumar M, Sacanna S, Thutupalli S, van den Bogaart G. Modulation of immune responses by particle size and shape. Front Immunol. 2020;11:607945.
47. Morhenn VB, Lemperle G, Gallo RL. Phagocytosis of different particulate dermal filler substances by human macrophages and skin cells. Dermatol Surg. 2002;28:484-90.
48. Matlaga BF, Yasenchak LP, Salthouse TN. Tissue response to implanted polymers: the significance of sample shape. J Biomed Mater Res. 1976;10:391-7.
49. Dong Y, Zhang Y, Yu H, et al. Poly-L-lactic acid microspheres delay aging of epidermal stem cells in rat skin. Front Immunol. 2024;15:1394530.
50. Kim HW, Jung YA, Yun JM, et al. Effects of Poly-L-lactic acid on adipogenesis and collagen gene expression in cultured adipocytes irradiated with ultraviolet B rays. Ann Dermatol. 2023;35:424-31.
51. Avelar LE, Nabhani S, Wüst S. Unveiling the mechanism: injectable Poly-L-lactic acid’s evolving role-insights from recent studies. J Cosmet Dermatol. 2025;24:e16635.
52. Amiri M, Meçani R, Niehot CD, et al. Skin regeneration-related mechanisms of calcium hydroxylapatite (CaHA): a systematic review. Front Med. 2023;10:1195934.
53. John S, Moorthy RK, Sebastian T, Rajshekhar V. Evaluation of hand function in healthy individuals and patients undergoing uninstrumented central corpectomy for cervical spondylotic myelopathy using nine-hole peg test. Neurol India. 2017;65:1025-30.
54. Dal Col V, Marchi C, Ribas F, et al. In vitro comparative study of calcium hydroxyapatite (Stiim): conventional saline dilution versus poly-micronutrient dilution. Cureus. 2025;17:e80344.
55. Trindade de Almeida AR, Marques ERMC, Contin LA, Trindade de Almeida C, Muniz M. efficacy and tolerability of hyperdiluted calcium hydroxylapatite (Radiesse) for neck rejuvenation: clinical and ultrasonographic assessment. Clin Cosmet Investig Dermatol. 2023;16:1341-9.
56. Sato M, Muniz M, Ferreira LRC. Treatment of mid-face aging with calcium hydroxylapatite: focus on retaining ligament support. Clin Cosmet Investig Dermatol. 2024;17:2545-53.
57. Schneider C, Parra Hernandez LA, Cure E, Salas I, Parra AM. Calcium hydroxyapatite as a co-adjuvant treatment option in a patient with morphea: a report of a case with a one-year follow-up. Cureus. 2024;16:e69741.
