fig1

Figure 1. Study design of grafted full-thickness burn wound in ovine model that closely mimics clinical scenario. The full-thickness burn was induced by fire flame (below left). Split-thickness skin grafts were harvested to be meshed and grafted (below center). Wounds in the treatment group received topical application of timolol (0.02 ml/cm² of 0.5%), and wounds in the control group received saline in a similar manner. The groups were assigned to allow comparison of contralateral sites as pairs in order to avoid anatomic location-dependent wound healing variations (below right).