REFERENCES

1. Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control 2005;16:83-95.

2. Eassa HA, Eltokhy MA, Fayyaz HA, et al. Current topical strategies for skin-aging and inflammaging treatment: science versus fiction. J Cosmet Sci 2020;71:321-50.

3. Moreno R, Nájera L, Mascaraque M, Juarranz Á, González S, Gilaberte Y. Influence of serum vitamin D level in the response of actinic keratosis to photodynamic therapy with methylaminolevulinate. J Clin Med 2020;9:398.

4. Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)2 vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011;25:543-59.

5. Vuolo L, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol (Lausanne) 2012;3:58.

6. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol 2014;21:319-29.

7. Tongkao-On W, Carter S, Reeve VE, et al. CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds. J Steroid Biochem Mol Biol 2015;148:72-8.

8. Slominski AT, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC. The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions. J Steroid Biochem Mol Biol 2014;144 Pt A:28-39.

9. Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med 2018;50:1-14.

10. Slominski AT, Chaiprasongsuk A, Janjetovic Z, et al. Photoprotective properties of vitamin D and lumisterol hydroxyderivatives. Cell Biochem Biophys 2020;78:165-80.

11. Markiewicz A, Brożyna AA, Podgórska E, et al. Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels. Sci Rep 2019;9:9142.

12. Aschrafi A, Meindl N, Firla B, Brandes RP, Steinhilber D. Intracellular localization of RORalpha is isoform and cell line-dependent. Biochim Biophys Acta 2006;1763:805-14.

13. Slominski AT, Brożyna AA, Zmijewski MA, et al. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest 2017;97:706-24.

14. Gu Y, Han J, Jiang C, Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev 2020;59:101036.

15. Masaki H. Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci 2010;58:85-90.

16. Cole MA, Quan T, Voorhees JJ, Fisher GJ. Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging. J Cell Commun Signal 2018;12:35-43.

17. Bocheva G, Slominski RM, Slominski AT. The impact of vitamin D on skin aging. Int J Mol Sci 2021;22:9097.

18. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005;289:F8-28.

19. Pizzino G, Irrera N, Cucinotta M, et al. Oxidative stress:harms and benefits for human health. Oxid Med Cell Longev 2017;2017:8416763.

20. Philips N, Samuel M, Parakandi H, et al. . Vitamins in the therapy of inflammatory and oxidative diseases. In: Atta-ur-Rahman, editor. Frontiers in clinical drug research-anti allergy agents. Bentham science; 2013; p. 240-64.

21. Philips N, Siomyk H, Bynum D, Gonzalez S. Skin cancer, polyphenols, and oxidative stress. Cancer 2014; doi: 10.1016/b978-0-12-405205-5.00026-x.

22. Philips N, Devaney J. Beneficial regulation of type I collagen and matrixmetalloproteinase-1 expression by estrogen, progesterone, and its combination in skin fibroblasts. J Am Aging Assoc 2003;26:59-62.

23. Krutmann J. The role of UVA rays in skin aging. Eur J Dermatol 2001;11:170-1.

24. Terra VA, Souza-Neto FP, Pereira RC, et al. Time-dependent reactive species formation and oxidative stress damage in the skin after UVB irradiation. J Photochem Photobiol B 2012;109:34-41.

25. Philips N, Hwang H, Chauhan S, Leonardi D, Gonzalez S. Stimulation of cell proliferation and expression of matrixmetalloproteinase-1 and interluekin-8 genes in dermal fibroblasts by copper. Connect Tissue Res 2010;51:224-9.

26. Philips N, Burchill D, O'Donoghue D, Keller T, Gonzalez S. Identification of benzene metabolites in dermal fibroblasts as nonphenolic: regulation of cell viability, apoptosis, lipid peroxidation and expression of matrix metalloproteinase 1 and elastin by benzene metabolites. Skin Pharmacol Physiol 2004;17:147-52.

27. Matsumura Y, Ananthaswamy HN. Toxic effects of ultraviolet radiation on the skin. Toxicol Appl Pharmacol 2004;195:298-308.

28. D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci 2013;14:12222-48.

29. Nishimura S. Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA. Free Radic Biol Med 2002;32:813-21.

30. Agar NS, Halliday GM, Barnetson RS, Ananthaswamy HN, Wheeler M, Jones AM. The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci U S A 2004;101:4954-9.

31. Portillo-Esnaola M, Rodríguez-Luna A, Nicolás-Morala J, et al. Formation of cyclobutane pyrimidine dimers after UVA exposure (Dark-CPDs) is inhibited by an hydrophilic extract of polypodium leucotomos. Antioxidants (Basel) 2021;10:1961.

32. Chaudhuri RK, Meyer T, Premi S, Brash D. Acetyl zingerone: an efficacious multifunctional ingredient for continued protection against ongoing DNA damage in melanocytes after sun exposure ends. Int J Cosmet Sci 2020;42:36-45.

33. Eiberger W, Volkmer B, Amouroux R, Dhérin C, Radicella JP, Epe B. Oxidative stress impairs the repair of oxidative DNA base modifications in human skin fibroblasts and melanoma cells. DNA Repair (Amst) 2008;7:912-21.

34. Philips N, Ding X, Kandalai P, Marte I, Krawczyk H, Richardson R. The beneficial regulation of extracellular matrix and heat shock proteins, and the inhibition of cellular oxidative stress effects and inflammatory cytokines by 1α, 25 dihydroxyvitaminD3 in non-irradiated and ultraviolet radiated dermal fibroblasts. Cosmetics 2019;6:46.

35. Philips N, Samuel P, Keller T, Alharbi A, Alshalan S, Shamlan SA. Beneficial regulation of cellular oxidative stress effects, and expression of inflammatory, angiogenic, and the extracellular matrix remodeling proteins by 1α,25-dihydroxyvitamin D3 in a melanoma cell line. Molecules 2020;25:1164.

36. Philips N, Keller T, Hendrix C, et al. Regulation of the extracellular matrix remodeling by lutein in dermal fibroblasts, melanoma cells, and ultraviolet radiation exposed fibroblasts. Arch Dermatol Res 2007;299:373-9.

37. Philips N, Conte J, Chen YJ, et al. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells. Arch Dermatol Res 2009;301:487-95.

38. Philips N, Samuel P, Lozano T, et al. Effects of humulus lupulus extract or its components on viability, lipid peroxidation, and expression of vascular endothelial growth factor in melanoma cells and fibroblasts. Madridge J Clin Res 2017;1:15-9.

39. Portillo M, Mataix M, Alonso-Juarranz M, et al. The aqueous extract of Polypodium leucotomos (Fernblock®) regulates opsin 3 and prevents photooxidation of melanin precursors on skin cells exposed to blue light emitted from digital devices. Antioxidants (Basel) 2021;10:400.

40. Song EJ, Gordon-Thomson C, Cole L, et al. 1α,25-dihydroxyvitamin D3 reduces several types of UV-induced DNA damage and contributes to photoprotection. J Steroid Biochem Mol Biol 2013;136:131-8.

41. Gordon-Thomson C, Gupta R, Tongkao-on W, Ryan A, Halliday GM, Mason RS. 1α,25 dihydroxyvitamin D3 enhances cellular defences against UV-induced oxidative and other forms of DNA damage in skin. Photochem Photobiol Sci 2012;11:1837-47.

42. Ke CY, Yang FL, Wu WT, et al. Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int J Med Sci 2016;13:147-53.

43. Wimalawansa SJ. Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation, and aging. Biology (Basel) 2019;8:30.

44. Lodish H, Berk A, Kaiser CA, et al. . Molecular cell biology. 8th ed. W.H. Freeman and Company; 2008. p. 1056-112.

45. Kindt TJ, Goldsby RA, Osborne BA. . Kuby Immunology. 6th ed. W.H. Freeman and Company; 2007. p. 312-8.

46. Philips N, Samuel P, Samuel M, Perez G, Khundoker R, Alahmade G. Interleukin-4 signaling pathway and effects in allergic diseases. CST 2018;13:76-80.

47. Philips N. Inhibition of interleukin-4 signalling in the treatment of atopic dermatitis and allergic asthma. Glob J Allergy 2015; doi: 10.17352/2455-8141.000019.

48. Geha RS, Jabara HH, Brodeur SR. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol 2003;3:721-32.

49. Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D. Nutrients 2015;7:8251-60.

50. Cannell JJ, Grant WB, Holick MF. Vitamin D and inflammation. Dermatoendocrinol 2014;6:e983401.

51. Chen Y, Xu T. Association of vitamin D receptor expression with inflammatory changes and prognosis of asthma. Exp Ther Med 2018;16:5096-102.

52. Cohen-Lahav M, Shany S, Tobvin D, Chaimovitz C, Douvdevani A. Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels. Nephrol Dial Transplant 2006;21:889-97.

53. Mantell DJ, Owens PE, Bundred NJ, Mawer EB, Canfield AE. 1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivo. Circ Res 2000;87:214-20.

54. Nakashyan V, Tipton DA, Karydis A, Livada R, Stein SH. Effect of 1,25(OH)2D3 and 20(OH)D3 on interleukin-1β-stimulated interleukin-6 and -8 production by human gingival fibroblasts. J Periodontal Res 2017;52:832-41.

55. Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal 2013;19:546-58.

56. Goldar S, Khaniani MS, Derakhshan SM, Baradaran B. Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev 2015;16:2129-44.

57. Bitomsky N, Hofmann TG. Apoptosis and autophagy: regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. FEBS J 2009;276:6074-83.

58. Hafner A, Bulyk ML, Jambhekar A, Lahav G. The multiple mechanisms that regulate p53 activity and cell fate. Nat Rev Mol Cell Biol 2019;20:199-210.

59. Bosch R, Philips N, Suárez-Pérez JA, et al. Mechanisms of photoaging and cutaneous photocarcinogenesis, and photoprotective strategies with phytochemicals. Antioxidants (Basel) 2015;4:248-68.

60. Speidel D. The role of DNA damage responses in p53 biology. Arch Toxicol 2015;89:501-17.

61. Keisala T, Minasyan A, Lou YR, et al. Premature aging in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol 2009;115:91-7.

62. Gupta R, Dixon KM, Deo SS, et al. Photoprotection by 1,25 dihydroxyvitamin D3 is associated with an increase in p53 and a decrease in nitric oxide products. J Invest Dermatol 2007;127:707-15.

63. Philips N, Keller T, Holmes C. Reciprocal effects of ascorbate on cancer cell growth and the expression of matrix metalloproteinases and transforming growth factor-beta. Cancer Lett 2007;256:49-55.

64. Philips N, Dulaj L, Upadhya T. Cancer cell growth and extracellular matrix remodeling mechanism of ascorbate; beneficial modulation by P. leucotomos. AntiCancer Res 2009;29:3233-8.

65. Herouy Y. Matrix metalloproteinases in skin pathology (review). Intl J Mol Med 2001;7:3-12.

66. Yan C, Boyd DD. Regulation of matrix metalloproteinase gene expression. J Cell Physiol 2007;211:19-26.

67. Verstappen J, Von den Hoff JW. Tissue inhibitors of metalloproteinases (TIMPs): their biological functions and involvement in oral disease. J Dent Res 2006;85:1074-84.

68. Dobak J, Grzybowski J, Liu F, Landon B, Dobke M. 1,25-Dihydroxyvitamin D3 increases collagen production in dermal fibroblasts. J Dermatol Sci 1994;8:18-24.

69. Hinek A, Botney MD, Mecham RP, Parks WC. Inhibition of tropoelastin expression by 1,25-dihydroxyvitamin D3. Connect Tissue Res 1991;26:155-66.

70. Bocheva G, Slominski RM, Slominski AT. Neuroendocrine aspects of skin aging. Int J Mol Sci 2019;20:2798.

71. Meehan M, Penckofer S. The role of vitamin D in the aging adult. J Aging Gerontol 2014;2:60-71.

72. Vitamin D. Fact Sheet for Health Professionals. Available from: https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/#h2 [Last accessed on 12 Jan 2022].

73. Gardner DG, Shoback D. . Greenspan’s basic and clinical endocrinology. 9th ed. McGraw Hill Medical; 2011.

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