REFERENCES
1. Bianchi B, Copelli C, Ferrari S, Ferri A, Sesenna E. Free flaps: outcomes and complications in head and neck reconstructions. J Craniomaxillofac Surg 2009;37:438-42.
2. Damian D, Esquenazi J, Duvvuri U, Johnson JT, Sakai T. Incidence, outcome, and risk factors for postoperative pulmonary complications in head and neck cancer surgery patients with free flap reconstructions. J Clin Anesth 2016;28:12-8.
3. Broome M, Juilland N, Litzistorf Y, et al. Factors influencing the incidence of severe complications in head and neck free flap reconstructions. Plast Reconstr Surg Glob Open 2016;4:e1013.
4. Zehr KJ, Dawson PB, Yang SC, Heitmiller RF. Standardized clinical care pathways for major thoracic cases reduce hospital costs. Ann Thorac Surg 1998;66:914-9.
5. Kehlet H, Wilmore DW. Multimodal strategies to improve surgical outcome. Am J Surg 2002;183:630-41.
6. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg 2017;152:292-8.
7. Fearon KC, Ljungqvist O, Von Meyenfeldt M, et al. Enhanced recovery after surgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr 2005;24:466-77.
8. Worrall DM, Tanella A, DeMaria S Jr, Miles BA. Anesthesia and enhanced recovery after head and neck surgery. Otolaryngol Clin North Am 2019;52:1095-114.
9. Smith TW Jr, Wang X, Singer MA, Godellas CV, Vaince FT. Enhanced recovery after surgery: a clinical review of implementation across multiple surgical subspecialties. Am J Surg 2020;219:530-4.
10. Low GMI, Kiong KL, Amaku R, et al. Feasibility of an enhanced recovery after surgery (ERAS) pathway for major head and neck oncologic surgery. Am J Otolaryngol 2020;41:102679.
11. Watson LJ, Ewers C. Enhanced recovery after head and neck cancer surgery: a review of current literature. Curr Opin Otolaryngol Head Neck Surg 2020;28:161-4.
12. Dort JC, Farwell DG, Findlay M, et al. Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: a consensus review and recommendations from the enhanced recovery after surgery society. JAMA Otolaryngol Head Neck Surg 2017;143:292-303.
13. Jandali DB, Vaughan D, Eggerstedt M, et al. Enhanced recovery after surgery in head and neck surgery: reduced opioid use and length of stay. Laryngoscope 2020;130:1227-32.
14. Kiong KL, Vu CN, Yao CMKL, et al. Enhanced recovery after surgery (ERAS) in head and neck oncologic surgery: A case-matched analysis of perioperative and pain outcomes. Ann Surg Oncol 2021;28:867-76.
15. Won HR, An JY, Lee JJ, et al. The effectiveness of an enhanced recovery after surgery protocol in head and neck cancer surgery with free-flap reconstruction. Ann Surg Treat Res 2019;97:239-44.
16. Chorath K, Go B, Shinn JR, et al. Enhanced recovery after surgery for head and neck free flap reconstruction: a systematic review and meta-analysis. Oral Oncol 2021;113:105117.
17. Ricon I, Hanalis-Miller T, Haldar R, Jacoby R, Ben-Eliyahu S. Perioperative biobehavioral interventions to prevent cancer recurrence through combined inhibition of β-adrenergic and cyclooxygenase 2 signaling. Cancer 2019;125:45-56.
18. Kiecolt-glaser JK, Page GG, Marucha PT, Maccallum RC, Glaser R. Psychological influences on surgical recovery: Perspectives from psychoneuroimmunology. Am Psychol 1998;53:1209-18.
19. Egbert LD, Battit GE, Welch CE, Bartlett MK. Reduction of postoperative pain by encouragement and instruction of patients. a study of doctor-patient rapport. N Engl J Med 1964;270:825-7.
20. Adams MT, Chen B, Makowski R, Bevans S, Boseley M. Multimedia approach to preoperative adenotonsillectomy counseling. Otolaryngol Head Neck Surg 2012;146:461-6.
21. Chan Y, Irish JC, Wood SJ, et al. Patient education and informed consent in head and neck surgery. Arch Otolaryngol Head Neck Surg 2002;128:1269-74.
22. Alshadwi A, Nadershah M, Carlson ER, Young LS, Burke PA, Daley BJ. Nutritional considerations for head and neck cancer patients: a review of the literature. J Oral Maxillofac Surg 2013;71:1853-60.
23. Duffy AM, Halaki M, Spigelman A, Chin V, Gallagher RM, Flood VM. Nutritional parameters associated with hospital admissions in patients being treated for head and neck cancer. Support Care Cancer 2020;28:341-9.
24. Onodera T, Goseki N, Kosaki G. Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi 1984;85:1001-5.
25. Imai T, Asada Y, Morita S, et al. Preoperative prognostic nutritional index as a method to predict postoperative complications after major head and neck surgery with free tissue transfer reconstruction. Jpn J Clin Oncol 2020;50:29-35.
26. Yoshida R, Gohara S, Sakata J, et al. Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy. Transl Oncol 2020;13:100850.
27. Mueller SA, Mayer C, Bojaxhiu B, et al. Effect of preoperative immunonutrition on complications after salvage surgery in head and neck cancer. J Otolaryngol Head Neck Surg 2019;48:25.
28. Rashid J, Kumar SS, Job KM, Liu X, Fike CD, Sherwin CMT. Therapeutic potential of citrulline as an arginine supplement: a clinical pharmacology review. Paediatr Drugs 2020;22:279-93.
29. Böger RH, Bode-Böger SM. The clinical pharmacology of L-arginine. Annu Rev Pharmacol Toxicol 2001;41:79-99.
30. Booi DI, Debats IBJG, Deutz NEP, van der Hulst RRWJ. Arginine improves microcirculation in the free transverse rectus abdominis myocutaneous flap after breast reconstruction: a randomized, double-blind clinical trial. Plast Reconstr Surg 2011;127:2216-23.
31. Alexander JW, Supp DM. Role of arginine and omega-3 fatty acids in wound healing and infection. Adv Wound Care (New Rochelle) 2014;3:682-90.
32. Kirk SJ, Hurson M, Regan MC, Holt DR, Wasserkrug HL, Barbul A. Arginine stimulates wound healing and immune function in elderly human beings. Surgery 1993;114:155-9; discussion 60.
33. Luis DA, Izaola O, Cuellar L, Terroba MC, Martin T, Aller R. High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. Eur Rev Med Pharmacol Sci 2009;13:279-83.
34. Luis DA, Izaola O, Cuellar L, Terroba MC, Martin T, Ventosa M. A randomized double-blind clinical trial with two different doses of arginine enhanced enteral nutrition in postsurgical cancer patients. Eur Rev Med Pharmacol Sci 2010;14:941-5.
35. Luis DA, Izaola O, Terroba MC, Cuellar L, Ventosa M, Martin T. Effect of three different doses of arginine enhanced enteral nutrition on nutritional status and outcomes in well nourished postsurgical cancer patients: a randomized single blinded prospective trial. Eur Rev Med Pharmacol Sci 2015;19:950-5.
36. Angele MK, Smail N, Ayala A, Cioffi WG, Bland KI, Chaudry IH. L-arginine: a unique amino acid for restoring the depressed macrophage functions after trauma-hemorrhage. J Trauma 1999;46:34-41.
37. Heyland DK, Novak F, Drover JW, Jain M, Su X, Suchner U. Should immunonutrition become routine in critically ill patients? JAMA 2001;286:944-53.
38. Howes N, Atkinson C, Thomas S, Lewis SJ. Immunonutrition for patients undergoing surgery for head and neck cancer. Cochrane Database Syst Rev 2018;8:CD010954.
39. Aeberhard C, Mayer C, Meyer S, et al. Effect of preoperative immunonutrition on postoperative short-term outcomes of patients with head and neck squamous cell carcinoma. Head Neck 2018;40:1057-67.
40. Duggan EW, Carlson K, Umpierrez GE. Perioperative hyperglycemia management: an update. Anesthesiology 2017;126:547-60.
41. Fish LH, Weaver TW, Moore AL, Steel LG. Value of postoperative blood glucose in predicting complications and length of stay after coronary artery bypass grafting. Am J Cardiol 2003;92:74-6.
42. Hua J, Chen G, Li H, et al. Intensive intraoperative insulin therapy versus conventional insulin therapy during cardiac surgery: a meta-analysis. J Cardiothorac Vasc Anesth 2012;26:829-34.
43. Fleisher LA, Fleischmann KE, Auerbach AD, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;130:2215-45.
44. Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration. Anesthesiology 2017;126:376-93.
45. Thorell A, Nygren J, Ljungqvist O. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Metab Care 1999;2:69-78.
46. Svanfeldt M, Thorell A, Hausel J, Soop M, Nygren J, Ljungqvist O. Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjects. Clin Nutr 2005;24:815-21.
47. Bilku DK, Dennison AR, Hall TC, Metcalfe MS, Garcea G. Role of preoperative carbohydrate loading: a systematic review. Ann R Coll Surg Engl 2014;96:15-22.
48. de Carvalho CS, Silva TH, André JCS, et al. Preoperative Fasting abbreviation with whey protein reduces the occurrence of postoperative complications in patients with head and neck cancer: a randomized clinical trial. Nutr Clin Pract 2021;36:665-72.
49. Tsutsumi R, Kakuta N, Kadota T, et al. Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial. J Anesth 2016;30:842-9.
50. Perrone F, da-Silva-Filho AC, Adôrno IF, et al. Effects of preoperative feeding with a whey protein plus carbohydrate drink on the acute phase response and insulin resistance. A randomized trial. Nutr J 2011;10:66.
51. Lassig AAD, Lindgren BR, Itabiyi R, Joseph AM, Gupta K. Excessive inflammation portends complications: Wound cytokines and head and neck surgery outcomes. Laryngoscope 2019;129:E238-46.
52. Murphy GS, Szokol JW, Marymont JH, Greenberg SB, Avram MJ, Vender JS. Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg 2008;107:130-7.
53. Hunter JM. Reversal of residual neuromuscular block: complications associated with perioperative management of muscle relaxation. Br J Anaesth 2017;119:i53-62.
54. Hung KC, Lin YT, Chen KH, et al. The effect of perioperative vitamin c on postoperative analgesic consumption: a meta-analysis of randomized controlled trials. Nutrients 2020;12:3109.
55. Ayatollahi V, Dehghanpour Farashah S, Behdad S, Vaziribozorg S, Rabbani Anari M. Effect of intravenous vitamin C on postoperative pain in uvulopalatopharyngoplasty with tonsillectomy. Clin Otolaryngol 2017;42:139-43.
56. Chen JY, Chang CY, Feng PH, Chu CC, So EC, Hu ML. Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. Clin J Pain 2009;25:562-9.
57. Shibuya N, Humphers JM, Agarwal MR, Jupiter DC. Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery--systematic review and meta-analysis. J Foot Ankle Surg 2013;52:62-6.
58. Li R, Shen L, Yu X, Ma C, Huang Y. Vitamin C enhances the analgesic effect of gabapentin on rats with neuropathic pain. Life Sci 2016;157:25-31.
59. Moore MG, Bhrany AD, Francis DO, Yueh B, Futran ND. Use of nasotracheal intubation in patients receiving oral cavity free flap reconstruction. Head Neck 2010;32:1056-61.
60. Coyle MJ, Main B, Hughes C, et al. Enhanced recovery after surgery (ERAS) for head and neck oncology patients. Clin Otolaryngol 2016;41:118-26.
61. Coyle MJ, Shrimpton A, Perkins C, Fasanmade A, Godden D. First do no harm: should routine tracheostomy after oral and maxillofacial oncological operations be abandoned? Br J Oral Maxillofac Surg 2012;50:732-5.
62. Coyle MJ, Tyrrell R, Godden A, et al. Replacing tracheostomy with overnight intubation to manage the airway in head and neck oncology patients: towards an improved recovery. Br J Oral Maxillofac Surg 2013;51:493-6.
63. Nagarkar R, Kokane G, Wagh A, et al. Airway management techniques in head and neck cancer surgeries: a retrospective analysis. Oral Maxillofac Surg 2019;23:311-5.
64. Coyle MJ, Shrimpton A, Perkins C, Fasanmade A, Godden D. First do no harm: should routine tracheostomy after oral and maxillofacial oncological operations be abandoned? Br J Oral Maxillofac Surg 2012;50:732-5.
65. Singh T, Sankla P, Smith G. Tracheostomy or delayed extubation after maxillofacial free-flap reconstruction? Br J Oral Maxillofac Surg 2016;54:878-82.
66. Gemmill EH, Humes DJ, Catton JA. Systematic review of enhanced recovery after gastro-oesophageal cancer surgery. Ann R Coll Surg Engl 2015;97:173-9.
67. Feng F, Ji G, Li JP, et al. Fast-track surgery could improve postoperative recovery in radical total gastrectomy patients. World J Gastroenterol 2013;19:3642-8.
68. So JB, Lim ZL, Lin HA, Ti TK. Reduction of hospital stay and cost after the implementation of a clinical pathway for radical gastrectomy for gastric cancer. Gastric Cancer 2008;11:81-5.
69. Lewis SJ, Egger M, Sylvester PA, Thomas S. Early enteral feeding versus "nil by mouth" after gastrointestinal surgery: systematic review and meta-analysis of controlled trials. BMJ 2001;323:773-6.
70. Kawasaki N, Suzuki Y, Nakayoshi T, et al. Early postoperative enteral nutrition is useful for recovering gastrointestinal motility and maintaining the nutritional status. Surg Today 2009;39:225-30.
71. Guidera AK, Kelly BN, Rigby P, MacKinnon CA, Tan ST. Early oral intake after reconstruction with a free flap for cancer of the oral cavity. Br J Oral Maxillofac Surg 2013;51:224-7.
72. Wu JM, Kuo TC, Chen HA, et al. Randomized trial of oral versus enteral feeding for patients with postoperative pancreatic fistula after pancreatoduodenectomy. Br J Surg 2019;106:190-8.
73. Sun HB, Li Y, Liu XB, et al. written on behalf of the AME Thoracic Surgery Collaborative Group. Early oral feeding following McKeown minimally invasive esophagectomy: an open-label, randomized, controlled, noninferiority trial. Ann Surg 2018;267:435-42.
74. Hutcheson KA, Bhayani MK, Beadle BM, et al. Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: use it or lose it. JAMA Otolaryngol Head Neck Surg 2013;139:1127-34.
75. Kerawala CJ, Riva F, Paleri V. The impact of early oral feeding following head and neck free flap reconstruction on complications and length of stay. Oral Oncol 2021;113:105094.
76. Eustaquio M, Medina JE, Krempl GA, Hales N. Early oral feeding after salvage laryngectomy. Head Neck 2009;31:1341-5.
77. Medina JE, Khafif A. Early oral feeding following total laryngectomy. Laryngoscope 2001;111:368-72.
78. McAuley D, Barry T, McConnell K, Smith J, Stenhouse J. Early feeding after free flap reconstruction for oral cancer. Br J Oral Maxillofac Surg 2015;53:618-20.
79. Poisson M, Longis J, Schlund M, et al. Postoperative morbidity of free flaps in head and neck cancer reconstruction: a report regarding 215 cases. Clin Oral Investig 2019;23:2165-71.
80. Patel PN, Valmadrid AC, Hong DY, Francis DO, Sim MW, Rohde SL. Immediate use of uncuffed tracheostomy after free flap reconstruction of the head and neck. Otolaryngol Head Neck Surg 2018;159:242-8.
81. Twose P, Thomas C, Morgan M, Broad MA. Comparison of high-flow oxygen therapy with standard oxygen therapy for prevention of postoperative pulmonary complications after major head and neck surgery involving insertion of a tracheostomy: a feasibility study. Br J Oral Maxillofac Surg 2019;57:1014-8.
82. Corley A, Caruana LR, Barnett AG, Tronstad O, Fraser JF. Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth 2011;107:998-1004.
83. Kelly M, Gillies D, Todd DA, Lockwood C, Kelly M. Heated humidification versus heat and moisture exchangers for ventilated adults and children. Cochrane Database of Systematic Reviews. Chichester: John Wiley & Sons, Ltd; 1996.
84. Brown JE, Holloway SL. An evidence-based review of split-thickness skin graft donor site dressings. Int Wound J 2018;15:1000-9.
86. Sinha S, Schreiner AJ, Biernaskie J, Nickerson D, Gabriel VA. Treating pain on skin graft donor sites: review and clinical recommendations. J Trauma Acute Care Surg 2017;83:954-64.
87. Batstone MD, Lowe D, Shaw RJ, Brown JS, Vaughan ED, Rogers SN. Passive versus active drainage following neck dissection: a non-randomised prospective study. Eur Arch Otorhinolaryngol 2009;266:121-4.
88. Abdel-Galil K, Mitchell D. Postoperative monitoring of microsurgical free tissue transfers for head and neck reconstruction: a systematic review of current techniques--part I. Non-invasive techniques. Br J Oral Maxillofac Surg 2009;47:351-5.
89. Lin PY, Liou TL, Lin KC, Hsieh MH, Chien CY, Hsieh CH. Immediate negative pressure wound therapy after free flap transfer for head and neck cancer surgery. Laryngoscope 2018;128:2478-82.
90. Moiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology 2002;96:725-41.
91. Reagan KML, O'Sullivan DM, Gannon R, Steinberg AC. Decreasing postoperative narcotics in reconstructive pelvic surgery: a randomized controlled trial. Am J Obstet Gynecol 2017;217:325.e1-325.e10.
92. Carpenter PS, Shepherd HM, McCrary H, et al. Association of celecoxib use with decreased opioid requirements after head and neck cancer surgery with free tissue reconstruction. JAMA Otolaryngol Head Neck Surg 2018;144:988-94.
93. Sanders JG, Dawes PJ. Gabapentin for perioperative analgesia in otorhinolaryngology-head and neck surgery: systematic review. Otolaryngol Head Neck Surg 2016;155:893-903.
94. Arumugam S, Lau CS, Chamberlain RS. Use of preoperative gabapentin significantly reduces postoperative opioid consumption: a meta-analysis. J Pain Res 2016;9:631-40.
95. Clark BS, Swanson M, Widjaja W, et al. ERAS for head and neck tissue transfer reduces opioid usage, peak pain scores, and blood utilization. Laryngoscope 2021;131:E792-9.
96. Sharbel D, Singh P, Blumenthal D, et al. Preoperative stellate ganglion block for perioperative pain in lateralized head and neck cancer: preliminary results. Otolaryngol Head Neck Surg 2020;162:87-90.
97. Roof S, Ferrandino R, Eden C, et al. Local infusion of ropivacaine for pain control after osseous free flaps: randomized controlled trial. Head Neck 2021;43:1063-72.
98. Murphy GS, Szokol JW, Avram MJ, et al. Intraoperative methadone for the prevention of postoperative pain: a randomized, double-blinded clinical trial in cardiac surgical patients. Anesthesiology 2015;122:1112-22.
99. Murphy GS, Szokol JW, Avram MJ, et al. Clinical effectiveness and safety of intraoperative methadone in patients undergoing posterior spinal fusion surgery: a randomized, double-blinded, controlled trial. Anesthesiology 2017;126:822-33.
100. Gobble RM, Hoang HLT, Kachniarz B, Orgill DP. Ketorolac does not increase perioperative bleeding: a meta-analysis of randomized controlled trials. Plast Reconstr Surg 2014;133:741-55.
101. Oliveira GS Jr, Agarwal D, Benzon HT. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg 2012;114:424-33.
102. Sekiguchi H, Inoue G, Nakazawa T, et al. Loxoprofen sodium and celecoxib for postoperative pain in patients after spinal surgery: a randomized comparative study. J Orthop Sci 2015;20:617-23.
103. Du E, Farzal Z, Stephenson E, et al. Multimodal analgesia protocol after head and neck surgery: effect on opioid use and pain control. Otolaryngol Head Neck Surg 2019;161:424-30.
104. Bahl V, Shuman AG, Hu HM, et al. Chemoprophylaxis for venous thromboembolism in otolaryngology. JAMA Otolaryngol Head Neck Surg 2014;140:999-1005.
105. Forrest JB, Camu F, Greer IA, et al. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth 2002;88:227-33.
106. Schleiffarth JR, Bayon R, Chang KE, Van Daele DJ, Pagedar NA. Ketorolac after free tissue transfer: a comparative effectiveness study. Ann Otol Rhinol Laryngol 2014;123:446-9.
107. Dor P, Klastersky J. Prophylactic antibiotics in oral, pharyngeal and laryngeal surgery for cancer: (a double-blind study). Laryngoscope 1973;83:1992-8.
108. Johnson JT, Myers EN, Thearle PB, Sigler BA, Schramm VL Jr. Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope 1984;94:46-51.
109. Raine CH, Bartzokas CA, Stell PM, Gallway A, Corkill JE. Chemoprophylaxis in major head and neck surgery. J R Soc Med 1984;77:1006-9.
110. Bratzler DW, Dellinger EP, Olsen KM, et al. American Society of Health-System Pharmacists (ASHP). Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect (Larchmt) 2013;14:73-156.
111. Caprini JA, Arcelus JI, Hasty JH, Tamhane AC, Fabrega F. Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost 1991;17 Suppl 3:304-12.
112. Pattani KM, Byrne P, Boahene K, Richmon J. What makes a good flap go bad? Laryngoscope 2010;120:717-23.
113. Varadarajan VV, Arshad H, Dziegielewski PT. Head and neck free flap reconstruction: what is the appropriate post-operative level of care? Oral Oncol 2017;75:61-6.
114. Nkenke E, Vairaktaris E, Stelzle F, Neukam FW, St Pierre M. No reduction in complication rate by stay in the intensive care unit for patients undergoing surgery for head and neck cancer and microvascular reconstruction. Head Neck 2009;31:1461-9.
115. Wang D, Kong Y, Zhong B, Zhou X, Zhou Y. Fast-track surgery improves postoperative recovery in patients with gastric cancer: a randomized comparison with conventional postoperative care. J Gastrointest Surg 2010;14:620-7.
116. Blom RL, van Heijl M, Bemelman WA, et al. Initial experiences of an enhanced recovery protocol in esophageal surgery. World J Surg 2013;37:2372-8.
117. Lee L, Li C, Robert N, et al. Economic impact of an enhanced recovery pathway for oesophagectomy. Br J Surg 2013;100:1326-34.
