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Case Report  |  Open Access  |  19 Sep 2016

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

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Plast Aesthet Res 2016;3:302-5.
10.20517/2347-9264.2016.36 |  © 2016 OAE Publishing Inc.
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Palatal cysts are always confusing by defining their exact nomenclature or conclusive diagnosis. One of these presentations is globulomaxillary cyst which requires to be categorized under appropriate head for the management point of view. Though this entity appears to be of odontogenic in origin but because of its anatomical relation and histo-pathological background this is placed in non odontogenic group. Though the mechanism of its formation remains the same but this cyst cannot be mixed up with nasopalatine cyst as per their location. Globulomaxillary cyst appears as inverted pear shaped radiolucency in all radiological procedures. This remains asymptomatic for a long time and rarely gets infected. We present a 29-year-old male who reported with one year history of asymptomatic right side hard palate swelling. He was subsequently diagnosed as globulomaxillary cyst with the help of radiological modalities like computerized tomography and magnetic resonance imaging. This article will highlight mainly the clinical and radiological features of these cysts with particular reference to globulomaxillary cyst which is our presenting case.


Palatal cyst, globulomaxillary cyst, non-odontogenic, magnetic resonance imaging, computerized tomography


Cysts in the oral cavity can either be of soft tissue origin or from within the bone. Non-odontogenic hard palate cysts arise from the tissues which do not participate in tooth formation. There are many palatal cysts and their variants are encountered during the course of embryonic palate development. One of the cysts is globulomaxillary cyst and this terminology had a lot of dispute to be used. It was earlier thought to be of embryonic origin because of entrapment of the ectoderm but now this hypothesis is no longer considered. These have been considered as fissural entrapment of epithelium rather than embryonic ectoderm.[1] There are many other cysts reported in the palate region and have been categorized as per the origin and anatomical location.

Case report

A 29-year-old male reported to otolaryngology out-patient department with the swelling in the hard palate of one year duration [Figure 1].

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

Figure 1. A 29-year-old male with hard palate swelling which is slightly pink in coloration (white vertical arrow)

This was asymptomatic in the beginning but subsequently developed some roughness along with slight local tenderness. There was no history of trauma or fever. On examination there was slight protuberance over the right side of the hard palate. This was of slight dull pink in coloration. There was no ulceration seen locally over the swelling. There was no divergence of roots of central incisors. The adjoining teeth reacted normally to the electric vitalometer test and to temperature stimulation. All the biochemical parameters were within normal limits. The further detailed initial work up confirmed the swelling as that of the non odontogenic origin. The patient was referred for evaluation of the tumor. The oral occlusal film had confirmed the swelling of non odontogenic origin. The patient was subjected to plain as well as contrast enhanced computerized tomography (CT) scanning of the face and neck region. The findings revealed a radiolucent pear shaped non enhancing unilocular, inverted pear shaped cystic lesion 2.5 cm × 3.5 cm in size between the lateral incisor and canine on right side [Figure 2].

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

Figure 2. Contrast enhanced computerized tomography of face and neck region. (A) Axial section shows a radiolucent non enhancing lesion (white star) present on right side of the hard palate; (B) reformatted sagittal section shows the same as pear shaped lesion (horizontal white arrow) abutting the right nasal cavity; (C) reformatted coronal section shows the lesion is encroaching upon the right maxillary sinus (white star) without invading the same

There was also thinning out of the bony outline [Figure 3].

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

Figure 3. Non contrast computerized tomography of facial and neck region in 3D reformatted bone window. (A) Axial section shows expanded radiolucent lesion with "egg shell" appearance at the base of nasal region predominantly on right side (vertical white arrow); (B) sagittal section shows the superior extent of lesion from hard palate (white star); (C) coronal section delineate the lesion separate from the maxillary sinuses but obscuring the nasal passages predominantly on right side (white star)

Patient was also subjected to magnetic resonance imaging (MRI) scanning of face and neck region. The mass was of fluid density which was hypointense in T1W and hyperintense in T2W images. There were no associated findings [Figure 4].

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

Figure 4. Plain magnetic resonance imaging face and neck region. (A) T2W image shows the well contained hyperintense cystic lesion on right side of the hard palate (vertical arrow); (B) T2W sagittal image shows hyperintense well demarcated lesion on the superior part of the hard palate (white star) on right side; (C) same lesion in T2WI coronal section with its superior extent (vertical arrow)

Fine needle aspiration cytology has shown some seropurulent secretion and confirmed as non odontogenic cyst coming in the category of globulomaxillary cyst. The histo-pathological images were not available. The patient has been planned for enucleation of the cyst as this being the most preferred method of treatment of these entities.


Hard palate forms the floor of the nostrils and roof of the oral cavity. This is thicker in front and thin in its posterior aspect. Globulomaxillary cysts are still disputable in their origin but majority of studies have shown these as not of embryonic origin.[2]

Oral origin cysts can be placed in to two categories as follow: (1) non-odontogenic (fissural) category includes globulomaxillary, nasopalatine, median palatal and nasolabial (nasoalveolar) cysts; and (2) odontogenic category includes dentigerous cysts, primordial cysts, odontogenic keratocysts and residual cysts.

Globulomaxillary cysts fall in non-odontogenic category. These can be distinguished based on the origin of the epithelial rests. Odontogenic cysts arise from tooth developing epithelium contrary to non odontogenic which arise from the trapped epithelium because of the fusion of upper jaw bones.[3] Non-odontogenic cysts can further be differentiated on the basis of their anatomical location. All the cysts around incisive canal fall in this group [Figure 5].

Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst

Figure 5. Diagrammatic representation of hard palatal cysts as per locations. Globulomaxillary cyst (1), nasopalatine cyst (2), median palatal cyst (3) and nasolabial cyst (4) are shown as white oval regions

Globulomaxillary cysts arise at the junction between maxilla and premaxilla. There are three main subtypes of non-odontogenic fissural cysts described as nasoalveolar, nasopalatine and median palatal.[4] These are usually discovered during routine clinical or radiographic examinations. The average duration of these cysts vary from one week to two years. The occlusal images are the first to lead in radiological investigations. In plain X-ray this may present as radiolucent region. These are usually asymptomatic and also found as incidental findings in CT examinations. Their pathogenesis though controversial but non disintegrated epithelium in the fissural sites remains the most accepted hypothesis. These are usually painless and rarely get infected and that is the reason for their delayed diagnosis.[5] These are oval or round and hypodense on CT examination and do not enhance in post contrast studies. Bone resorption is often present because of their expansile nature but the cortical break is very rare. The classical egg shell type of margins is present as was also seen in our case. Hisatomi et al.[6] has described the classical features of these cysts in MRI. MRI show intermediate signal in T1W and hyper intensity on T2W images. There is no post-gadolinium enhancement seen in T1W fat saturated sequences. Histologically these present as a cystic cavity covered by epithelium that contain stratified squamous cells with some respiratory epithelial components. The wall is composed of thick dense collagenous fibrous tissues. Median palatine cysts are easy to diagnose on CT and MRI modalities as their locations are self explanatory.[7,8] There are cases where these entities have been managed with non-surgical endodontic treatment[9] but the gold standard is complete surgical excision via intraoral approach.[10] Sometimes the part of nasal mucosa has to be sacrificed as the lesion is close to the floor of the nose.[11]

In conclusion, globulomaxillary cysts draw attention only after these are diagnosed. These cysts remain undiagnosed for a long period because of their asymptomatic background. CT and MRI modalities have brought revolution in diagnosing these entities while performed for some other reasons. These should be classified in their proper category before treating them.

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Conflicts of interest

There are no conflicts of interest.

Patient consent

The consent of the patient was taken before subjecting the patient for investigation.

Ethics approval

The approval for publishing this case and paper had been obtained from the institute.


1. Haring P, Filippi A, Bornstein MM, Altermatt HJ, Buser D, Lambrecht JT. The "globulomaxillary cyst" a specific entity or a myth? Schweiz Monatsschr Zahnmed 2006;116:380-97. (in French, German)

2. Dammer U, Driemel O, Mohren W, Giedl C, Reichert TE. Globulomaxillary cysts--do they really exist? Clin Oral Investig 2014;18:239-46.

3. Alimendinger A, Gabe M, Destian S. Median palatine cyst. Neuroradiology 2009;3:7-10.

4. De Cuyper K, Vanhoenacker FM, Hintjens J, Verstraete KL, Parizel PM. Nasopalatine duct cyst. JBR-BTR 2008;91:179.

5. Yerli H, Cabbarpur C, Aydin E. CT findings of a nasoalveolar cyst. Br J Radiol 2009;82:e76-8.

6. Hisatomi M, Asaumi J, Konouchi H, Shigehara H, Yanagi Y, Kishi K. MR imaging of epithelial cysts of the oral and maxillofacial region. Eur J Radiol 2003;48:178-82.

7. Karacal N, Ambarcoglu O, Kutlu N. Median palatine cyst: report of an unusual entity. Plast Reconstr Surg 2005;115:1213-4.

8. Hadi U, Younes A, Ghosseini S, Tawil A. Median palatine cyst: an unusual presentation of a rare entity. Br J Oral Maxillfac Surg 2001;39:278-81.

9. Abdel-Azim MM. Healing of globulomaxillary cyst after non-surgical endodontic treatment--"case report". Egypt Dent J 1995;41:1295-8.

10. Fonseca R, Marciani R, Turvey T, editors. Oral and Maxillofacial Surgery. 2nd ed. St. Loius: Elsevier; 2008. pp. 418-65.

11. Hupp JR, Ellis E, Tucker MR. Contemporary oral and maxillofacial surgery. 5th ed. St. Louis: Mosby Elsevier; 2008. pp. 450-6.

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OAE Style

Sharma BB, Sharma S, Jha A, Sharma KD, Sharma JD, Sharma CB. Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst. Plast Aesthet Res 2016;3:302-5.

AMA Style

Sharma BB, Sharma S, Jha A, Sharma KD, Sharma JD, Sharma CB. Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst. Plastic and Aesthetic Research. 2016; 3: 302-5.

Chicago/Turabian Style

Bharat Bhushan Sharma, Shweta Sharma, Arvind Jha, Kamal Deep Sharma, Jai Deep Sharma, Chattur Bhuj Sharma. 2016. "Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst" Plastic and Aesthetic Research. 3: 302-5.

ACS Style

Sharma, BB.; Sharma S.; Jha A.; Sharma KD.; Sharma JD.; Sharma CB. Non-odontogenic hard palate cysts with special reference to globulomaxillary cyst. Plast. Aesthet. Res. 2016, 3, 302-5.

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Author Biographies

Dr. Bharat Bhushan Sharma is Professor & Head of Department of Radio-diagnosis, SGT Medical College, Gurgaon, India. He did Post Graduation from International Reputed Institute of PGIMER, Chandigarh, India. He then served in Army Medical Corps and later served in HP State Health Services and Central Health Services as consultant radiologist. He started different radiological services modalities like CT and MRI first time in Himachal Pradesh Health Services in the state. He has been teaching post graduates for the last 25 years and conducted various radiological research projects of Post Graduates & PhD students during 1995-2015. He has around 60 publications (national & international) at his credit. He joined the present institute on 01.05.2015 and got installed the latest modern radiological modalities to start Post Graduation in radio-diagnosis. Beside medical courses, he is also engaged in teaching allied health science courses, like Diploma in Radio Imaging Technology (DRIT), Bachelor of Radio Imaging Technology (BRIT) and Master of Radio Imaging Technology (MRIT) in the department.

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