Topic: From Staphylococcus aureus Colonization to Infection: Interaction with the Microbiome, Pathogenesis, Treatment, and Prevention Strategies

Staphylococcus aureus, an opportunistic pathogen, colonizes many healthy individuals but can also pose a risk for severe infections. Up to one-third of the healthy population harbors S. aureus in the nasopharyngeal area or on the skin as part of the natural microbiome. However, numerous studies have demonstrated that S. aureus colonization can serve as a reservoir for infections, including skin and wound infections, as well as bloodstream, bone, and pulmonary infections. The bacteria's array of virulence factors equips it to infect almost every organ in the body, leading to severe and life-threatening infections. The virulence of S. aureus is governed by a sophisticated regulatory network that promptly reacts to differing environmental conditions, facilitating bacterial spread and survival. Therefore, gaining a better understanding of the mechanisms involved in S. aureus transitioning from colonization to infection is paramount for devising effective treatment and prevention strategies.

This Special Issue welcomes submissions of full research articles, reviews, meta-analyses, systematic reviews, and perspectives on all aspects of S. aureus colonization and infection development. Particularly encouraged are submissions focusing on the areas of in vitro and in vivo infection models and different types of clinical trials, addressing the following areas:
1. S. aureus colonization and its interaction with the microbiome;
2. Mechanisms underlying S. aureus transition from colonization to infection;
3. Factors and conditions that initiate infection development;
4. Virulence and regulatory mechanisms involved in S. aureus colonization and infection development;
5. The role of other members of the microbiome in infection development, including co-infections;
6. Treatment and prevention strategies to restrain S. aureus transition during infection.

31 Mar 2025