Topic: Intestinal Microbiome, Metabolism, and Metabolic Syndrome

The prevalence and incidence of non-transmissible, cardio-metabolic, cancer and autoimmune disorders are increasing worldwide among genetically predisposed individuals because of sedentary behavior, unhealthy diets, and environmental pollution. The gut microbiome which plays a crucial role in maintaining metabolic and immune homeostasis within the host, also serves as critical link in the chain of events associating environmental triggers, lifestyle habits, health and disease states. Specifically, the intestinal microbiome-derived metabolites significantly impact the host's immuno-metabolism and systemic health.

A shift from the normal diversity of gut microbiome, known as gut dysbiosis, can disrupt the physiological metabolic homeostasis, trigger inappropriate immune responses and promote, among a subset of predisposed individuals, development and progression of several cardio-metabolic conditions, (including the metabolic syndrome), certain types of cancer, and autoimmune disorders.

However, how the gut microbiome influences metabolic and immunological physiological homeostasis remains incompletely understood and the relationship associating non-transmissible diseases and alterations in the gut microbiome continues to be a subject of extensive research in humans, and in preclinical models.

For this Special Issue, we invite submissions of all type of manuscripts exploring the role of genetics, sex, lifestyle habits (i.e., diets, alcohol, and physical activity), microorganisms, microbiome-derived metabolites, and probiotics in influencing host metabolism and immunity, with specific reference to non-transmissible disorders.

Manuscripts addressing the following topics either in clinical arena or in pre-clinical models are especially welcome:
1. Role of probiotics and intestinal microbiota in metabolic health, immune homeostasis, and cardio-metabolic disorders;
2. Impact of gut microbiota-derived metabolites on normal metabolism, immunity, and systemic health;
3. Mechanisms leading from intestinal microbiota dysbiosis to metabolic dysfunction, immune activation, and systemic low-grade, subclinical inflammation;
4. Interactions between intestinal microbiota, metabolism, and immunity, and their relationships with cardio-metabolic disorders, cancer, and autoimmune conditions.

31 Dec 2024