Topic: Neoadjuvant Therapy for Colorectal Cancer

Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced mid-to-lower rectal cancer. The neoadjuvant therapy approach for rectal cancer is continuously being optimized. This includes various strategies such as total neoadjuvant therapy, omission of radiotherapy, neoadjuvant immunotherapy, and the exploration of neoadjuvant therapy in early-stage rectal cancer. Additionally, for locally advanced colon cancer, neoadjuvant chemotherapy has also demonstrated certain advantages. On the whole, there remains some controversy regarding the selection criteria for neoadjuvant therapy and how to optimize the neoadjuvant treatment regimens to achieve the dual goals of reducing toxicity and enhancing efficacy. This special topic aims to explore the pertinent issues surrounding neoadjuvant therapy in colorectal cancer, offering insights to guide clinical treatment decisions.

31 Dec 2023