Topic: Autophagy in Neurological Disorders: Mechanisms and Therapeutic Implications

Autophagy is a conserved process that plays a crucial role in maintaining cellular homeostasis by regulating the quality and quantity of organelles and proteins. Selective autophagy, including ER-phagy, mitophagy, lysophagy, ribophagy, aggrephagy, and xenophagy, further highlights the precise control mechanisms that ensure autophagy occurs at the appropriate time and space upon cellular demand. Inappropriate activation or dysfunction of autophagy impairs brain function. Defective autophagy is linked to various neurological disorders, including Alzheimer’s disease, Parkinson’s disease, autism spectrum disorders, and others, by causing dysfunction of distinct types of cells such as neurons, glia, endothelial cells, and pericytes. This Special Issue invites original and review articles that delve into the regulatory mechanisms of selective autophagy and bulk autophagy, explore the pathophysiological function of autophagy in neurological disorders, and discuss the development of drugs targeting autophagy and their implication in the therapy of neurological disorders.

Autophagy, neurological disorders, mechanisms, selective autophagy, drug development

30 Apr 2024